Neurology

Journal Information
ISSN / EISSN : 00283878 / 1526632X
Current Publisher: Ovid Technologies (Wolters Kluwer Health) (10.1212)
Former Publisher: Ovid Technologies (Wolters Kluwer Health) (10.1097)
Total articles ≅ 48,474
Google Scholar h5-index: 112
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Jaume Roquer, Rosa Maria Vivanco-Hidalgo, Lluís L. Prats-Sánchez, Alejandro Martínez-Domeño, Daniel Guisado-Alonso, Elisa Cuadrado-Godia, Eva Giralt Steinhauer, Jordi Jiménez-Conde, Ana Rodríguez-Campello, Joan Martí-Fàbregas, et al.
Neurology; doi:10.1212/wnl.0000000000008462

The publisher has not yet granted permission to display this abstract.
Daniele Altomare, Arno De Wilde, Rik Ossenkoppele, Wiesje Pelkmans, Femke Bouwman, Colin Groot, Ingrid Van Maurik, Marissa Zwan, Maqsood Yaqub, Frederik Barkhof, et al.
Neurology; doi:10.1212/wnl.0000000000008361

The publisher has not yet granted permission to display this abstract.
Erin E. Sundermann, Pauline Maki, Anat Biegon, Richard B. Lipton, Michelle M. Mielke, Mary Machulda, Mark W. Bondi, For The Alzheimer's Disease Neuroimaging Initiative
Neurology; doi:10.1212/wnl.0000000000008467

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Iago Pinal-Fernandez, Christopher A. Mecoli, Maria Casal-Dominguez, Katherine Pak, Yuji Hosono, Julio Huapaya, Wilson Huang, Jemima Albayda, Eleni Tiniakou, Julie J. Paik, et al.
Neurology; doi:10.1212/wnl.0000000000008443

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Raoul Sutter, Kai Tisljar, Petra Opić, Gian Marco De Marchis, Stefano Bassetti, Roland Bingisser, Sabina Hunziker, Stephan Marsch
Neurology; doi:10.1212/wnl.0000000000008461

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Raymond Hupperts, Joost Smolders, Reinhold Vieth, Trygve Holmøy, Kurt Marhardt, Myriam Schluep, Joep Killestein, Frederik Barkhof, Manolo Beelke, Luigi M.E. Grimaldi, et al.
Neurology; doi:10.1212/wnl.0000000000008445

Abstract:Objective In the phase II, randomized, double-blind, placebo-controlled Supplementation of Vigantol Oil versus Placebo Add-on in Patients with Relapsing-Remitting Multiple Sclerosis (RRMS) Receiving Rebif Treatment (SOLAR) study (NCT01285401), we assessed the efficacy and safety of add-on vitamin D3 in patients with RRMS.Methods Eligible patients with RRMS treated with SC interferon-β-1a (IFN-β-1a) 44 μg 3 times weekly and serum 25(OH)D levels 3 14,007 IU/d (n = 113). The revised primary outcome was the proportion of patients with no evidence of disease activity (NEDA-3) at week 48.Results At 48 weeks, 36.3% of patients who received high-dose vitamin D3 had NEDA-3, without a statistically significant difference in NEDA-3 status between groups (placebo 35.3%; odds ratio 0.93; 95% confidence interval [CI] 0.53–1.63; p = 0.80). Compared with placebo, the high-dose vitamin D3 group had better MRI outcomes for combined unique active lesions (incidence rate ratio 0.68; 95% CI 0.52–0.89; p = 0.0045) and change from baseline in total volume of T2 lesions (difference in mean ranks: −0.074; p = 0.035).Conclusions SOLAR did not establish a benefit for high-dose vitamin D3 as add-on to IFN-β-1a, based on the primary outcome of NEDA-3, but findings from exploratory outcomes suggest protective effects on development of new MRI lesions in patients with RRMS.Clinicaltrials.gov identifier NCT01285401.Classification of evidence This study provides Class II evidence that for patients with RRMS treated with SC IFN-β-1a, 48 weeks of cholecalciferol supplementation did not promote NEDA-3 status.
Mathula Thangarajh, Jos Hendriksen, Michael P. McDermott, William Martens, Kimberly A. Hart, Robert C. Griggs, for The Muscle Study Group and TREAT-NMD
Neurology; doi:10.1212/wnl.0000000000008363

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Concetta Manno, Giulio Disanto, Giovanni Bianco, Stefania Nannoni, Mirjam Heldner, Simon Jung, Marcel Arnold, Johannes Kaesmacher, Mandy Müller, Sebastian Thilemann, et al.
Neurology; doi:10.1212/wnl.0000000000008362

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Carmen Tur, Tomas Kalincik, Jiwon Oh, Maria P. Sormani, Mar Tintoré, Helmut Butzkueven, Xavier Montalban
Neurology; doi:10.1212/wnl.0000000000008319

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Alberto J. Espay, Scott Ries, Thomas Maloney, Jennifer Vannest, Erin Neefus, Alok K. Dwivedi, Jane B. Allendorfer, Lawson R. Wulsin, W. Curt Lafrance, Anthony E. Lang, et al.
Neurology; doi:10.1212/wnl.0000000000008442

The publisher has not yet granted permission to display this abstract.