Journal of Pharmaceutical Research International

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EISSN : 2456-9119
Published by: Sciencedomain International (10.9734)
Total articles ≅ 2,531
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, Prerana Sakharwade, Sonali Kolhekar, Pooja Kasturkar, Shital Sakharkar
Journal of Pharmaceutical Research International pp 155-160; https://doi.org/10.9734/jpri/2021/v33i44b32660

Abstract:
Introduction: Dandy Walker Syndrome is a congenital brain malformation that affects the cerebellum and the fluid filled areas that accompany it. The cerebellum is a part of the brain that deals with movement coordination as well as cognition and behavior. Case Presentation: The male patient 8 year old who was apparently admitted in A.V.B.R.H on 18/8/2019 is diagnosed with a known case of dandy walker malformation and came with the complaints of headache since 4 days, fever since 3 days, vomiting since 5 days and 3 episodes of seizures. All the necessary blood investigations has been done. The CT scan as well as MRI reports has shown that large posterior fossa cyst with open communication with fourth ventricle with hypoplastic left cerebellar hemisphere and no visualized cerebellar vermis. Before taking this case, information was given to the patients and their relatives and Informed consent was obtained from patient as well as relatives. Therapeutic Intervention: The patient was treated with NSAIDS, antibiotics, anticonvulsant, antiemetic and antacid and physical therapy to help keep muscle strength and flexibility The patient underwent VP shunt head circumference assessed regularly, vital signs hourly, provided vitamins enriched diet as per dietician’s order assisted dressing for drainage and physical therapy. Conclusion: The patient was admitted in A.V.B.R.H in a critical condition with the diagnosis of dandy walker syndrome, after providing the required treatment by the health care team members of hospital the patient condition was improved and satisfactory.
, Seema Singh, Ruchira Ankar, Arati Raut, Savita Pohekar, Jaya Khandar, Achia Sawarkar, Pragati Alnewar
Journal of Pharmaceutical Research International pp 236-241; https://doi.org/10.9734/jpri/2021/v33i44b32672

Abstract:
Mycobacterium tuberculosis is the bacteria that cause tuberculosis. If the infection is not treated immediately the bacterium passes via the circulatory system and spread other organs and tissues. Pathogen will travel to the meninges and causes inflammation of membranes called as tubercular meningitis. Here, the authors report a case of tuberculous meningitis a 42- years-old male patient with the chief complaints of low grade fever with chills since 1 month, headache in frontal region since 5-6 days, altered sensorium, breathing difficulty, reduced speech and left side weakness of the body since 1 day. After admitting in the ward all investigation done like MRI brain, ECG, lumbar puncture, blood tests etc. and he diagnosed as tuberculous meningitis. Patient admitted in AVBRH in ICU, investigations done, where patient was on NIV support, nasogastric tube, foleys catheter and it has been removed as patient was improving the condition and shifted in ward. Patient medical treatment in the ward was inj. C-tri 2 gm, Inj.levoflox 500 mg, inj. thimine 100 mg, Inj.Dexamethasone 10 mg, tab. Pan 40 mg, tab. Akt4 3, Inj.manitol, tab. Lorazepam. History collection, Physical examination, neurological assessment and nursing care plan were done after all treatment patient condition has been improved.
, Jaya Gawai, Pooja Kasturkar, Mayur Wanjari
Journal of Pharmaceutical Research International pp 209-213; https://doi.org/10.9734/jpri/2021/v33i44b32668

Abstract:
Introduction: An impaired relationship with reality is a hallmark of psychosis. It is a sign of a serious mental disorder. People with psychosis may have delusions or hallucinations. The way your brain processes information can be affected by psychosis. Losing touch with reality is caused by it. It's possible to see, hear, or believe things that aren't true. Psychosis is a symptom, not a disease. It can be caused by a mental or physical illness, substance abuse, or stress. This case report aims to provide nursing care for psychosis. The objectives of this case report are to identify psychosis symptoms by the nurses and to report immediately and to take action immediately and to prevent complications. Case Presentation: A 17-years adolescent male admitted at Acharya Vinoba Bhave Rural Hospital Sawangi (M) Wardha with Auditory Hallucinations in psychosis since 7 (2014) years was admitted to a psychiatric ward with a chief complaint of muttering and smiling to self, decreased interaction sleep disturbance, aggressiveness. The perpetuating factors are poor drug compliance. Conclusion: The patient underwent psycho pharmacotherapy and the patient taking the medications regularly and minimized the symptoms. The relatives were informed about the prognosis and finally patient was discharged. The nurses play a vital role at the bedside and take care of psychiatric patients with auditory hallucinations effective nursing interventions for an adolescent male with auditory hallucinations in psychosis enhancing and improving patient’s mental illness who experience auditory hallucinations in psychosis.
, Shrikrishna Baokar, Kavita Mane, Gauri Patil, Rajendra Patil, Prabhat Jain, AdityaNath Pandey
Journal of Pharmaceutical Research International pp 191-198; https://doi.org/10.9734/jpri/2021/v33i44b32665

Abstract:
The medicinal herb Dioscorea floribunda (Linn.) is very significant. Varahikanda's medicinal properties are quite important. It is used to treat various diseases in Ayurvedic literature. Here is a summary of studies on the antiquity and ayurvedic qualities of varahikanda, i.e. Dioscorea floribunda. Varahikanda has a variety of pharmacological characteristics, according to the research. Jeevaneeya, Rasayana, Balya, Krumighna, Pramehaghna, Kushtaghna, Vrushya, Nadivrun, Visarpa, Udarshool, Raktapitta are all Ayurvedic terms. It has antimicrobial action, wound healing activity, antihyperglycemic activity, dyslipidemic activity, anticancer activity, immunomodulatory activity, antioxidant activity, antiinflammatory and analgesic activity, antihelmintic activity, and aphrodisiac activity, according to contemporary research.
, Seema Singh
Journal of Pharmaceutical Research International pp 172-177; https://doi.org/10.9734/jpri/2021/v33i44b32662

Abstract:
“Fast food is a food which is speedily available as well as provides, frequently at eating places as well as seasonally related with not so much cost and nutritional things like hamburgers, French fries, and soda.” The teenagers of today will be the future of tomorrow; therefore, concentrating on today's adolescents and educating them on how to modify their behaviours toward healthy eating patterns is critical. The dietary issue is one of the most serious health issues confronting millions of children of all ages. There are lots of effects of fast food on the health of adolescents. Because of peer pressure, shortage of time, attractive packages and tastes they become closer to take fast food. Fast foods are at large quantity obtain in educational institutions through various stores. Canteens are available in educational institutions to offer soda water, soft drink, cracks and lots of other foods of less nutritious rate(value). There are many ill impacts and effects of fast food and persons are not aware of its dangerous effects. It can cause many harmful disorders. Prolonged use of fast food is the reason for medical issues, chubbiness means obesity, GI Tract problem and increased fat. Excessive intake of fast foods may reduce appetite and eliminate the chance for nutrients in foods. These quick meals are rich in fat, salt, and sugar, and they are the root cause of chronic illnesses such as obesity, diabetes, and cancer in later years of life. This review focuses on what is fast food and its effect on adolescents and the evidence of its effects on mortality, morbidity and quality of life.
Rakesh Davella,
Journal of Pharmaceutical Research International pp 161-171; https://doi.org/10.9734/jpri/2021/v33i44b32661

Abstract:
Background: Diabetes is a significant health problem that has reached worrisome proportions: almost half of the world's population now has diabetes. Diabetes mellitus, or diabetes, is a severe, long-term disease in which a person's blood glucose levels are elevated due to their body's inability to make any or enough insulin, or to properly utilise the insulin that it does produce. The chemicals extracted from medicinal plants were shown to be both safer and more bioactive than manufactured medicines. Objective: The goal of this research was to use molecular docking to find possible binding affinities of luteolin, a phytocompound from Rumex vesicarius L, to five target proteins, in order to find the lead molecule against diabetes. Methodology: One chemical was isolated from Rumex vesicarius L. leaves in this research. The binding affinity of the complexes was calculated using molecular docking studies. The docking procedure was carried out using AutoDock Tools 1.5.6, which brought the ligand together with the target proteins. Results: The binding energies of Luteolin with major Glutamine-fructose-6-phosphate amido transferase (GFAT1), Pancreatic α-Amylase, Forkhead box protein O1(FOX01), α--glucosidase, and Dipeptidyl peptidase-4 (DPP-4) were determined to be -6.89, -6.80, -6.36, -9.35, and -7.72 kcal. Conclusion: Our findings suggest that luteolin can target not only α--glucosidase but also DPP4 and other targets, suggesting that they may be used as type 2 diabetes mellitus inhibitors. We believe that this phytochemical, luteolin, may be utilised in preclinical studies as an anti-diabetic drug to combat diabetes mellitus.
Shaheen Bhatty, , Mohammad Nashit, Faiza Zafar Sayeed, Fariha Asad
Journal of Pharmaceutical Research International pp 214-219; https://doi.org/10.9734/jpri/2021/v33i44b32669

Abstract:
Objective: To compare insulin resistance and beta-cell function in nondiabetic, prediabetic, and diabetic subjects in a subset of obese Pakistani population. Materials and Methods: Two hundred and ten obese subjects underwent anthropometric measurements. After overnight fasting for 8 hours, 6 cc blood was drawn for fasting blood glucose level, fasting insulin level. Blood glucose samples were taken after drinking 75 gm glucose in 260 ml water. HOMA IR and HOMA BETA% were calculated by the formula. Subjects were divided into obese nondiabetic, obese prediabetic and obese diabetic according to WHO criteria. Results: Out of 210 obese subjects, 53 (25.2%) were males and 157 (74.8%) were females. The mean BMI was 32.39±5.21. Mean abdominal circumference was 102.78±10.16. There were 101(48%) obese nondiabetic, 51(24%) were found to be obese prediabetic, 58(28%) were found to be obese diabetic. Mean insulin resistance in obese nondiabetic subjects was 2.8 ±3.7, in prediabetic 8.5± 12.3, in diabetic was 17.7±24.6. Mean HOMA beta was 245.3±267.4 in obese nondiabetic subjects, 290.5±298.4 in prediabetic, and 16.6±57 in diabetic. Conclusion: There was a significantly increased incidence of prediabetes and diabetes in obese subjects. Prediabetic and diabetic subjects were found to have marked insulin resistance. Beta-cell function was markedly reduced in diabetic subjects having a family history of diabetes, emphasizing the genetic predisposition to develop beta-cell exhaustion.
, Archana Taksande, Ms. Shweta Fating, Komal Jadhav, Avishkar Bhandekar, Manojith Pradhan
Journal of Pharmaceutical Research International pp 220-228; https://doi.org/10.9734/jpri/2021/v33i44b32670

Abstract:
Background: Accident means-Unfortunate incident that happens unexpectedly and unintentionally, The common cause of school accident is playground equipment and risk factors of the school accident are age, Most common injury occurs in schoolers is hand injury and foot injury, a road traffic accident is the most common type of accident. Primary prevention of an accident first AID and supportive care of school accident is health education and health check-up is done by half-yearly. Objectives: 1) To assess the knowledge of primary school teachers on the prevention of accidents among schoolers in selected schools in the Wardha district.2) To compare knowledge regarding prevention of accidents in schoolers between male and female primary teachers.3) To compare knowledge regarding prevention of accidents in schoolers between rural and urban area. 4) To associate the knowledge of primary teachers regarding the prevention of accidents among schoolers with selected demographic variables. Methods: An descriptive research methodology, a non-experimental descriptive design was used to perform this analysis. Non-probability convenient sampling technique was used to select the available individual as a subject in the study. A structured questionnaire was developed to assess the knowledge of urban and rural 100 primary school teachers regarding the prevention of accidents among schoolers. The sample attributes have been defined by frequency, percentage, after data collection. The Chi-square test was also used to figure out the correlation between knowledge and specified demographic variables. Results: The study findings show 0 (0%) of rural primary school teachers were having a poor level of knowledge score, 8(16%) of rural primary school teachers were having an average level of knowledge score, 21(42%) of rural primary school teachers were having a good level of knowledge score, 19 (38%) of rural primary school teachers had a very good level of knowledge score and 2 (4%) of rural primary school teachers had excellent knowledge score. The minimum score was 5 and the maximum score was 20, the mean score was 11.68 ± 3.13 with a mean percentage score of 58.40 ±15.69. The study findings show 1(2%) of urban primary school teachers were having a poor level of knowledge score, 5(10%) of urban primary school teachers were having an average level of knowledge score, 18(36%) of urban primary school teachers were having a good level of knowledge score, 20 (40%) of urban primary school teacher had a very good level of knowledge score and 6 (12%) of urban primary school teacher had excellent knowledge score. The minimum score was 5 and the maximum score was 20, the mean score was 12.62 ± 3.32 with a mean percentage score of 63.10 ±16.62. In the overall comparison of the rural primary school teachers having good knowledge regarding prevention of accidents of schoolers rather than urban primary school teachers. Conclusion: Schoolers accident is a common problem in rural and urban school children. The main aim of the study was to assess the knowledge regarding the prevention of accidents of schoolers among the primary school teachers of the selected rural and urban areas of Maharashtra.
Yakymenko Volodymyr Viktorovych, Sementsov Alexander Sergijovich, Ponomarenko Viktorij Viktorivna
Journal of Pharmaceutical Research International pp 203-208; https://doi.org/10.9734/jpri/2021/v33i44b32667

Abstract:
Aims: Search for non-invasive methods for diagnosing late transplant kidney dysfunction, which can improve control and monitor the condition of the kidney transplant, characterization diagnostic role of dopplerography of renal vessels in patients with late dysfunction of the transplanted kidney. Study design: When conducting dopplerometry, blood flow indices were analyzed from 3 to 6 cycles of heart contractions, followed by an averaged indicator. In addition, the linear blood flow velocity was assessed separately from the renal vein. Place and Duration of Study: For the period 2016-2017 Ultrasound of an allopod was performed in 60 recipients of RT (RENAL TRANSPLANT) in the late postoperative period. Methodology: The average age of the patients was 38.89 ± 1.52 years. There were 34 men (56.6 7%), 26 women (43.33%). All patients were divided into two groups: patients with preserved function and patients with RT (RENAL TRANSPLANT) dysfunction. Related kidney transplantation (RRT) was performed in 55.0% of patients, in 45.0% - cadaveric kidney transplantation (CKP). The groups were comparable in the main clinical and demographic parameters. Results: The reverse dynamics was observed when examining the level of the renal filtration function indicator, the estimated glomerular filtration rate (SKF) - at a TAMX level of more than 15 cm/sec, glomerular filtration was 51.18 ± 1.93 (47.32-55.04) ml/min (p <0.01), and with a decrease in TAMX of less than 15 cm/sec, the level of SKF decreased significantly, more than twice, to the level of 25.40 ± 2.19 (21.02-29.78) ml/min <0.001). Conclusion: The determination of dopplerographic parameters for TP with preserved and especially with impaired depuration function with a direct assessment of TAMX opens up wide opportunities in non-invasive assessment of RT (RENAL TRANSPLANT) changes, identification of developing complications, as well as improved transplant survival.
Kalpana Thalava Vigila J
Journal of Pharmaceutical Research International pp 229-235; https://doi.org/10.9734/jpri/2021/v33i44b32671

Abstract:
The urinary tract infections (UTI’s) are common infections that can affect kidneys, ureters, and urethra. About 40% of urinary tract infections are caused during hospitalization and globally an estimated 600,000 patients are affected per year. Urinary tract infections are more prevalent in women due to their short urethra and its anatomical proximity to the anal orifice. A bladder infection may cause pelvic pain, increased urge to urinate, pain with urination and blood in the urine. A kidney infection may cause back pain, nausea, vomiting and fever. Bacteriuria is a major risk factor for the development of urinary tract infections during pregnancy and with further risk of preterm birth & pyelonephritis if untreated. This study was carried out to isolate and identify bacteria involved in the first trimester of pregnancy. A cross sectional study was conducted from February, 2019 to June 2019. Structured questionnaires were used to collect data from pregnant women. UTI was diagnosed by urine culture on standard culture media. Out of 25 pregnant women included in this study, 15 (60.0%) were symptomatic and 10 (40.0%) asymptomatic. Escherichia coli(64%) was the most commonly found bacterial isolate followed by Psedomonas aeruginosa (20%), Klebsiella sp. (12%) and Proteus sp. (0.4%). Antibiotic susceptibility test by Kirby-Bayer Disc diffusion method revealed that all the bacterial isolates subjected to antibiogram test were sensitive or susceptible to Gentamycin, Nalidixic acid, Nitrofurantoin, Amikacin and Co-trimoxazole, and resistant to Amoxicillin, Norfloxacin and erythromycin were resistant to all bacterial isolates.
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