Current Trends in Biomedical Engineering & Biosciences

Journal Information
EISSN : 2572-1151
Published by: Juniper Publishers (10.19080)
Total articles ≅ 373
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Amanda Baracho Trindade Hill, Antonio Alexandre Speri Alves, Rodrigo Da Silva Nunes Barreto, Fabiana Fernandes Bressan, Maria Angelica Miglino, Joaquim Mansano Garcia
Current Trends in Biomedical Engineering & Biosciences, Volume 20, pp 1-4; https://doi.org/10.19080/ctbeb.2021.20.556028

Abstract:
Introduction: Female infertility is a condition that is currently treated through the maximization of existing reserves; a necessity due to the fact that a true reversal of the processes leading to infertility is not yet technologically possible. This experiment examined the ability of mesenchymal stem cells to differentiate into primordial germ cells (PGC) when cultured onto the placental scaffold. Methods: To produce the scaffolds, the cotelydons were collected and decellularized by umbilical vessel SDS perfusion. Adipose derived cells were isolated based on rapid adherence to the plastic. Results: The isolated cells displayed the markers CD90 and 105, while lacked CD34 and CD45. When seeded onto the scaffold, the cells successfully differentiated into PGC like cells, displaying typical PGCs markers, including STELLA, OCT4, DAZL and VASA. Discussion: These materials were chosen for their low cost and wide availability. The data in this study show the promising potential of cell-scaffold complex to support the development of female tissue engineering-based regenerative medicine therapies.
Alicia García Falgueras
Current Trends in Biomedical Engineering & Biosciences, Volume 20, pp 1-4; https://doi.org/10.19080/ctbeb.2021.20.556027

Abstract:
Polymerase Chain Reaction (PCR) is a molecular technique more suitable for accurate diagnoses because of its specificity in targeting and identifying specific pathogens. PCR technique is reliable to detect the genetic presence of the virus in the host since the very beginning of the infection, no matter how the immune system of the person might react. Moreover, the samples for the test contains the DNA information during quite a long time since the extraction. Programmable thermal operation cycler for controlling heating and cooling is the procedure to denaturation into two single strands, annealing and extension reactions of the DNA. The PCR is certainly having a clinical approach, because do not emphasized on how the immune system of the patient might reacts to the infection, only on whether the specific virus is present or not for the accurate diagnoses and subsequently proceed with an appropriated medical treatment to restore health.
Current Trends in Biomedical Engineering & Biosciences, Volume 19, pp 1-4; https://doi.org/10.19080/ctbeb.2020.19.556024

Abstract:
Macrofungi (mushrooms) have widely been appreciated all over the world for their nutritional values and medicinal properties. They have been used in traditional medicine for more than 3000 years for prevention and treatment of different diseases. Modern scientific research shows that mushrooms are producers of a broad spectrum of high- and low-molecular-weight bioactive compounds, i.e., alkaloids, polysaccharides, proteins, phenolics, terpenoids, polyketides, cyclic peptides, lectins and ribosome-inactivating proteins. They have various therapeutic effects as antidiabetic, anti-inflammatory, antimicrobial, antioxidant, anti-tumorous, antiviral, cardioprotective, hepatoprotective, hypocholesterolemic, hypotensive, immunomodulatory, neuroprotective and regenerative, and possess promising pharmacological potential. Development of fungal biotechnological cultivation industry will support production of mushroom-derived biotech products, healthy food and mycopharmaceuticals pharmaceuticals. Further advances in fungal biology and biotechnology, genomics and proteomics will assist biomedical research and application of macrofungi.
Pittella F, Gualberto Acm Valle Abcs, Gualberto Acm
Current Trends in Biomedical Engineering & Biosciences, Volume 19, pp 116-121; https://doi.org/10.19080/ctbeb.2020.19.556022

Abstract:
After twenty years of short interfering RNA (siRNA) research, RNA interference (RNAi)-based medicines are emerging as a novel class of drugs since the recent approval of Onpattro® and Givlaari® by the Food and Drug Administration (FDA). RNAi is a post-transcriptional gene regulatory process in which one of its molecular effectors is a silencing inducer: the siRNA. Since the description of this pathway, several research groups are searching for therapeutic applications of siRNA against diseases with overexpressed genes. Many challenges came across and strategies to improve siRNA stability and delivery were developed. Nevertheless, higher efficacy, safety and successful delivery are still some of the challenges to be overcome. In this mini review, we are presenting some of the biological barriers for effective siRNA delivery as well as an update of the current progress in RNAi-based medicines in phase III clinical trials.
Omar Pérez, Juan E. Miño, Agustín García, Erenio González
Current Trends in Biomedical Engineering & Biosciences, Volume 18, pp 1-4; https://doi.org/10.19080/ctbeb.2019.18.555998

Anca Stefania Mesaros, Aranka Ilea, Adela Cristina Lazăr, Andreeas-Vasile Bojor, Georgeta Victoria Inceu, Radu Septimiu Câmpian, Anida-Maria Băbțan, Nausica Bianca Petrescu, Adina Bianca Boșca
Current Trends in Biomedical Engineering & Biosciences, Volume 17, pp 1-6; https://doi.org/10.19080/ctbeb.2019.17.555969

Mohammad Sarwar Mir, Neelam Kotwal, Sunil Kumar, Monika Malhotra, Pankaj Kumar
Current Trends in Biomedical Engineering & Biosciences, Volume 17, pp 1-2; https://doi.org/10.19080/ctbeb.2019.17.555968

Mohammad Sarwar Mir, Neelam Kotwal, Sunil Kumar, Monika Malhotra, Pankaj Kumar
Current Trends in Biomedical Engineering & Biosciences, Volume 17, pp 1-2; https://doi.org/10.19080/ctbeb.2019.17.555967

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