Annals of Woman and Child Health

Journal Information
ISSN / EISSN : 24560138 / 24560138
Current Publisher: Marwah Infotech (10.21276)
Total articles ≅ 14
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Published: 30 January 2018
Annals of Woman and Child Health; doi:10.21276/awch

SurajWasudeo Nagre, KrishnaraoNarayanrao Bhosle
Published: 15 December 2017
Annals of Woman and Child Health, Volume 3; doi:10.21276/awch.1803

Abstract:Patent Ductus Arteriosus ( PDA ) is one of the commonest acyanotic congenital heart disease.Surgical or device closure is done when medical management fails.Choice of management depends on size of PDA. A study was conducted to assess the type of surgical technique to be followed either direct ligation or division and suturing.10 Cases of PDA were studied from May 2012 to May 2017 ages ranged from 12 days to five years with youngest weighing 650 grams.There were no postoperative complications and death.In two patients division suturing done and in other eight ligation was done.Repeat 2 D echo after three months did not show recanalization in either group.Conclusion was both techniques are equally effective but division suturing was more difficult than ligation. DOI: 10.21276/AWCH.1803
Sheetal Arora, Sujata Raychaudhuri, Deepshikha Rana
Published: 15 December 2017
Annals of Woman and Child Health, Volume 3; doi:10.21276/awch.1808

Abstract:Exaggerated placental site (EPS) is defined as a non-neoplastic condition in which there is proliferation of number of implantation site intermediate trophoblastic cells that infiltrates the endometrium and myometrium. This is a benign lesion and it’s an exaggeration of normal physiological process as the intermediate trophoblastic cells present in EPS are similar morphologically and immunophenotypically to those found in the normal implantation site. An exaggerated placental site may occur in association with normal pregnancy or an abortion. The significance of reporting this lesion lies in the fact that the cells of this lesion display an identical morphological features to the intermediate trophoblastic cells found in placental site trophoblastic tumour, placental site nodule & epithelioid trophoblastic tumour. To confirm the morphological analysis, we used immunohistochemistry panel comprising of Cytokeratin 18, p63 and ki-67(MIB-1). We here present a rare case of an exaggerated placental site in a 30-year-old female who was in her first trimester of pregnancy and presented with signs of incomplete abortion. DOI: 10.21276/AWCH.1808
Mohd Rafey, Kafil Akhtar, AtiaZakaur Rab, Shahid Ali Siddiqui
Published: 15 December 2017
Annals of Woman and Child Health, Volume 3; doi:10.21276/awch.1782

Abstract:Locally advanced breast cancer (LABC) continues to be a common presentation of breast cancer worldwide. Various serum markers have been studied to know the behaviour, metastasis and prognosis of breast cancer without going through any invasive procedure. CA 15-3 measures the protein product of the MUC 1 gene and is the most commonly used serum marker in breast cancer. The main use of serum CA 15-3 is monitoring therapy response and elevated levels are associated with metastatic disease and in non-metastatic patients, it is associated with poor prognosis. The aim of the study was to know the role of serum CA 15-3 level in diagnosis, prognosis and therapy response in patients with locally advanced breast cancer and to assess its relationship with other variables like tumor size, microscopic grade, nodal burden and Ki-67 antigen expression. Serum CA 15-3 levels significantly decreased after neo-adjuvant chemotherapy and mastectomy and it remained elevated in patients with suspected or hidden metastasis. Serum CA 15-3 levels exhibited positive statistically significant correlation with tumor size. DOI: 10.21276/AWCH.1782
Priyadarshini D, Arathi C.A
Published: 15 December 2017
Annals of Woman and Child Health, Volume 3; doi:10.21276/awch.1812

Abstract:Fallopian tube duplication is a rare Mullerian duct anomaly which is seldom reported in available literature studies. We present a rare case of unilateral duplication of the fallopian tube in a 36-year-old female during routine grossing of hysterectomy specimen. Microscopic examination revealed normal histology of bilateral fallopian tubes along with the accessory Fallopian tube on one side. Fallopian tube duplication may contribute to infertility, ectopic pregnancy and can be a cause for failure of sterilization
Ashmeet Kaur, Mansi Faujdar, Tushar Kariya, Shubha Gupta
Published: 15 December 2017
Annals of Woman and Child Health, Volume 3; doi:10.21276/awch.1804

Abstract:Background: To study or analyse the histomorphological spectrum and distribution of benign and malignant ovarian neoplasms in women of different age groupsMethods: 633 cases of ovarian tumors were studied over a period of 6 years(from July 2011 to July 2017) at the Department of Pathology, SDMH. All the cases were subjected to histopathological examination and IHC as & when required.Results: In total,633 ovarian tumor specimens were examined. Out of which ,468 cases (73.9%)were benign, 23 (3.6%)were boderline and 142(22.4%)were malignant. Most of the benign tumors occurred between 31 & 40 years of age while malignant lesions presented commonly between 41 & 50 years of age. Most common histological types were serous cystadenoma (24.18%) followed by mature cystic teratoma (22.90%).The commonest benign tumor was serous cystadenoma & the commonest malignant tumor was serous cystadenocarcinoma. Serous tumors showed bilateral involvement more commonly than bilateral mucinous tumors.Conclusion-: We noted that serous cystadenoma tumors are the commonest variety of ovarian tumors. Also the age of presentation of these malignant tumors was an earlier age as compared to others. DOI: 10.21276/AWCH.1804
Lakshmi Agarwal, Manmohan Agrawala, Bhawna Gupta
Published: 15 December 2017
Annals of Woman and Child Health, Volume 3; doi:10.21276/awch.1806

Abstract:Introduction: Pregnancy associated breast cancer is defined as "The diagnosis of breast cancer is made during pregnancy or within one year afterward." The incidences of breast carcinoma are 1 in 3000 pregnancy in west. Risk is increasing because of increased number of late pregnancies. Young age, lactating breast (dense) and paucity of incidences not only delay but confuse the pathologist for accurate diagnosis.Case report A 28 year lactating female with 2 months old baby, presented with breast lump. Lump was mobile, non-tender and of size 2x1 cm since 3 months and gradually increasing in size. On USG, it was benign. On FNAC, aspirate was milky mixed with blood, showing monotonous cells with abundant cytoplasm, bland nuclei in a secretary background. Final diagnosis was lactational changes in breast. After six months, lady came back with previous lump which was increased in size up to 6X5 cm. On FNAC, smear was having bizarre cells, reported as malignant and confirmed on histopathology. Patient was responded to chemotherapy and lump reduced in size.Conclusion: Pregnancy associated breast cancer is on rise. High grade of suspicion and complete evaluation including trucut biopsy will lead to correct diagnosis. DOI: 10.21276/AWCH.1806
Anamika Jaiswal, Ankit Kaushik, A K Singh
Published: 15 December 2017
Annals of Woman and Child Health, Volume 3; doi:10.21276/awch.1820

Abstract:Background: 2D:4D ratio is a sexually dimorphic marker that act as potential marker of prenatal androgen exposure. Genital development in fetus depends on adequate and timely exposure to sex steroids. Assessment of fetal androgen levels and exposure are essential to predict normal development and future reproductive disorders. The 2D:4D ratio can be used to assess androgen action.Aim: This study attempts to find out 2D:4D ratio of left and right hand in adult females and males and to find out whether any difference exists among these variables in males and females.Methods: A total of 83 adults were included in the study. There were 51 females and 32 males. The distance of second finger and fourth finger was calculated from mid-point of proximal most digital crease to distal most end of the finger. The ratio was then obtained by dividing second finger length by fourth finger length. Result: The mean 2D: 4D ratio of left hand and right hand in adult female were 0.98 and 0.99 respectively. The mean 2D: 4D ratio of left hand and right hand in adult male were 0.967 and 0.99 respectively. The males have lower 2D:4D ratio for left and right hand as compared to females. The mean 2D:4D ratio of left hand and right hand in left handed females were 0.99 and 1.01 respectively while mean 2D:4D ratio of left hand and right hand in right handed females were 0.987 and 0.99. The mean 2D:4D ratio of left hand and right hand in left handed males were 0.96 and 0.98 respectively while mean 2D:4D ratio of left hand and right hand in right handed males were 0.98 and 1.01.Conclusion: Sexually dimorphic markers are variables that can be used as indirect marker of fetal androgen exposure. In this study the mean 2D:4D ratio in males for both left and right hand was lower than females in overall group and in case of both right and left handedness males and females. Male fetuses with higher testosterone levels will have a lower 2D:4D ratio. Digital ratio is an easy noninvasive parameter, abnormal 2D:4D ratio in females can predict excessive androgen action.
Sumanashree Mallappa, Nimisha Sharma, Arti Khatri, Vimal Bhandari
Annals of Woman and Child Health, Volume 3; doi:10.21276/AWCH.1543

Abstract:IntroductionCancer of the breast in women is a major health burden worldwide. It is the most common cause of cancer among women in both high-resource and low-resource settings, and is responsible for over one million of the estimated 10 million neoplasms diagnosed worldwide each year in both sexes. Limited number of studies have addressed the optimal surgical management of patients with breast carcinoma associated with benign or pathologic nipple dischargeMaterial and methods-Thirteen breast carcinoma cases with nipple discharge were studied. Nipple discharge cytology was studied using giemsa method. Later all the mastectomy specimens were inked and sectioned from medial to lateral into no greater than 1 cm thick tissue sections and grossly examined. Extensive sampling of nipple areola was followed taking 12 sections from each nipple areolar complex.Thirteen breast carcinoma cases without nipple discharge were chosen as control and also grossed and examined for nipple areolar involvement .Results-In our study, there were 13 cases with nipple discharge. Out of which, 10 cases were having benign cytologic findings and 3 cases showed malignant cytologic findingsSpss statistical software was used which showed no association between presence of nipple discharge and nipple areolar involvement also it showed no association between malignant nipple discharge cytologic findings and nipple areolar involvement.Conclusions-Nipple discharge itself has no association with nipple areolar involvement and should not deter a clinician from nipple sparing mastectomy if other factors are conducive. Careful patient selection can be done in cases with malignant nipple discharge cytologic findings, if negative margins could be achieved and appropriate adjuvant therapy given.Further studies are needed to study the role of nipple discharge cytology in conservative mastectomy procedures.DOI: 10.21276/AWCH.1543
Shaanthy Gunasingh Thangiah Kasirajan, Padmalatha Dakshnamurthy, Indhumathi Nachiyar, Prasanna Karthik Suthakaran, Kannan Rajendran
Annals of Woman and Child Health, Volume 3; doi:10.21276/AWCH.1461

Abstract:Background: Gestational Diabetes Mellitus (GDM) is an emerging problem which affects a large number of pregnant women in India. Women with GDM have been shown to have abnormal lipid profiles with higher serum triacylglycerol concentrations but lower LDL levels. Early detection reduces adverse maternal and foetal outcome. The Lipid Accumulation Product (LAP) is an index of fat distribution and assessment which can be easily measured in an outpatient setup.Methods: This study was a hospital based case control study. Cases were 30 pregnant women, newly diagnosed with GDM in their 2nd trimester while controls were 30 apparently healthy pregnant women without risk factors for GDM. Lipid accumulation product (LAP) was computed by multiplying a sex-specific estimate of waist circumference and the fasting triglyceride concentration, LAP = (WC [cm] - 58) x TGL [mmol/L].Result: The mean age of patients with GDM was higher when compared to controls. (28.17 ± 3.34 vs 24.40 ± 3.07, p < 0.0001) The lipid profile showed a significantly higher value of serum triglycerides among cases while the differences in HDL were not statistically significant. Lipid accumulation product (LAP) in GDM patients was found to be significantly elevated when compared to controls. (133.43 ± 64.02 vs 62.89 ± 30.68, p < 0.0001)Conclusion: Calculation of LAP can be done to identify the degree of risk for developing GDM. So LAP can possibly serve as in future as a screening tool for the diagnosis of GDM in an outpatient setting in resource poor settings. DOI: 10.21276/AWCH.1461