Journal of Clinical and Scientific Research

Journal Information
ISSN / EISSN : 2277-5706 / 2277-8357
Published by: Medknow (10.4103)
Total articles ≅ 444
Archived in
EBSCO
SHERPA/ROMEO
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Latest articles in this journal

Arvind Achra, Shiwangi Sharma, Abhinaya Venugopal, Desh Deepak, Kirti Nirmal, Stuti Kansra, Anuradha Shulania, Mala Chhabra, Nandini Duggal
Journal of Clinical and Scientific Research, Volume 10; https://doi.org/10.4103/jcsr.jcsr_19_21

SaurabhRamBihariLal Shrivastava, PrateekSaurabh Shrivastava
Journal of Clinical and Scientific Research, Volume 10; https://doi.org/10.4103/jcsr.jcsr_101_20

Siddharth Sarkar, Gayatri Bhatia
Journal of Clinical and Scientific Research, Volume 10; https://doi.org/10.4103/jcsr.jcsr_1_21

Aparna R Bitla, K Rama, Narendra Hulikal, Mutheeswaraiah Yootla, Lakshmi Amancharla Yadagiri, T Asha, M Manickavasagam, Pv L. N. Srinivasa Rao
Journal of Clinical and Scientific Research, Volume 10; https://doi.org/10.4103/jcsr.jcsr_44_20

Abstract:
Background: Micro-ribonucleic acids (miRNAs) are small non-coding RNAs that regulate gene expression. Expression of miRNAs has been shown to be dysregulated in patients with breast cancer. These markers have been shown to be potential markers of diagnostic significance. We intended to study the usefulness of miRNA-155 and miRNA-205 in monitoring response to surgery by monitoring their pre- and post-operative expression.Methods: Twenty patients newly diagnosed with malignant breast disease along with 20 age-matched females not having any breast lesion were included in the study. Reverse transcription–polymerase chain reaction was used to assess the expression of circulating miRNAs.Results: MiRNA-155 was found to be significantly upregulated and miRNA-205 was significantly downregulated in patients with breast cancer compared to controls. There was no change in expression of miRNA-155 and miRNA-205 following surgery.Conclusions: The findings of the present study do not support the role of miRNA-155 and miRNA-205 as markers suitable for follow-up. However, the findings of the present study need to be confirmed in a larger sample size and samples collected over a defined post-operative period.
GandikotaRamesh Kumar, Kaavya Nettikoppula, Sridevi Kota
Journal of Clinical and Scientific Research, Volume 10; https://doi.org/10.4103/jcsr.jcsr_102_19

Mallikarjuna Shetty, KamaniNaresh Babu, Eegi Vidyasree, Mnageshwar Rao
Journal of Clinical and Scientific Research, Volume 10; https://doi.org/10.4103/jcsr.jcsr_19_20

Karanam Gowrinath, Maneesha Regati, E Srikanth
Journal of Clinical and Scientific Research, Volume 10; https://doi.org/10.4103/jcsr.jcsr_25_21

Nagaraj Perumal, RajeevKumar Jain, Archa Sharma, Deepti Chaurasia
Journal of Clinical and Scientific Research, Volume 10; https://doi.org/10.4103/jcsr.jcsr_90_20

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