Kidney international. Supplement

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ISSN / EISSN : 0098-6577 / 0098-6577
Published by: Springer Nature (10.1038)
Total articles ≅ 1,817
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, Suresh Mathew, Richard Lund, Yifu Fang, Toshifumi Sugatani
Kidney international. Supplement, Volume 79; https://doi.org/10.1038/ki.2011.24

Abstract:
Risk factors for disease states are rigorously defined. This analysis considers the definition of a risk factor as applied to the question of whether the serum phosphorus level is a risk factor for cardiovascular disease. Observational studies strongly suggest that phosphorus is associated with cardiovascular risk, and definitive prospective animal studies are supportive. A plausible mechanism of action has been discovered demonstrating that phosphorus stimulates osteoblastic transition of cells in the neointima of atherosclerotic plaques, which, if prevented, blocks vascular calcification. However, prospective studies demonstrating that modulation of the putative risk factor affects clinical outcomes are lacking, and phosphorus, as yet, does not qualify as a cardiovascular risk factor. This is a clarion call for additional research.
, Tsutomu Hirohashi, , Francesca Minnei, A. Bernard Collins, R. Neal Smith
Published: 1 December 2010
Kidney international. Supplement, Volume 78; https://doi.org/10.1038/ki.2010.436

Abstract:
B cells have many possible mechanisms by which they can affect allograft survival, including antigen presentation, cytokine production, immune regulation, and differentiation into alloantibody-producing plasma cells. This report reviews the last mechanism, which the authors regard as most critical for the long-term survival of allografts, namely, the promotion of chronic rejection by alloantibodies. Chronic humoral rejection characteristically arises late after transplantation and causes transplant glomerulopathy, multilamination of peritubular capillary basement membranes, and C4d deposition in PTCs and glomeruli. Circulating antidonor human leukocyte antigen class II antibodies are commonly detected and may precede the development of graft injury. Prognosis is poor, especially when recognized after graft dysfunction has developed. Improved detection and treatment are critically needed for this common cause of late graft loss.
Roger N. Greenwood, , Fiorella Gastaldon, Alessandra Brendolan, Peter Homel, , Lenore Bruno, Mary Carter, Nathan W. Levin
Published: 1 November 2003
Kidney international. Supplement, Volume 64; https://doi.org/10.1046/j.1523-1755.64.s87.12.x

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, H Ha, S I Kim, F N Ziyadeh
Published: 1 September 2000
Kidney international. Supplement, Volume 77

, H Sugiyama, N Kashihara
Published: 1 September 2000
Kidney international. Supplement, Volume 77

The publisher has not yet granted permission to display this abstract.
M E Choi
Published: 1 September 2000
Kidney international. Supplement, Volume 77

The publisher has not yet granted permission to display this abstract.
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