The European Research Journal
EISSN : 2149-3189
Current Publisher: The European Research Journal (10.18621)
Total articles ≅ 531
Latest articles in this journal
The European Research Journal; doi:10.18621/eurj.900847
Objectives: The most diagnosed tumor among infiltrating tumors of the female genital tract is endometrial carcinoma. The Wnt/β-catenin signaling pathway has an important role in organogenesis, self-renewal of tissues, and adult stem cell maintenance. However aberrant activation of it causes many types of tumors and also related to the prognosis of patients. Therefore, we aimed to investigate whether Wnt/β-catenin pathway inhibitors have any effect on the proliferation and migration of tumor cells. Methods: As cancer cell line, HEC-1A endometrial adenocarcinoma was used. The Wnt/β-catenin pathway inhibitors effects on proliferation and migration were demonstrated by real-time cell analysis device and wound healing model respectively. Results: Wnt/β-catenin pathway inhibitors FH535 (25 μM at 36th hour, p < 0.05; 50μM at 48th hour p < 0.001) and niclosamide inhibited cell proliferation (10, 25 and 50μM at 60th hours; p < 0.01, p < 0.05 and p < 0.001, respectively) whereas ICRT14 and IWP-2 did not. However only niclosamide which is also an antihelmintic drug inhibited migration of the cells in all concentrations tested (10, 25 and 50μM, p < 0.05). Conclusions: The present study shows that the Wnt/β-catenin pathway has an substantial role in both proliferation and migration of endometrial adenocarcinoma. We suggest that the antihelmintic drug niclosamide could be further investigated for its potential therapeutic effect in endometrial adenocarcinoma.
The European Research Journal; doi:10.18621/eurj.822818
Objectives: The etiology of pilonidal sinus disease is still controversial. Acquired theory in its etiology has become more popular nowadays. The aim of this study was to investigate the effects of dominant hand use on sinus features and sinus direction. Methods: Eight hundred and sixty-five patients with diagnosis of primer pilonidal sinus disease were included. Data on patients’ ages, BMI, over-sitting histories, duration of disease, dominant hand use histories, the condition of their sinuses at the time of presentation, the number of sinus openings, sinus directions, and sinus extension directions were collected. Relationship was evaluated between dominant hand use and sinus direction or sinus extension direction. Results: There was no statistically significant difference between the patients’ ages, sexes, BMI figures, the durations of disease and over- sitting history and dominant hand use. While the sinus directions of patients who had shorter duration of disease were towards the midline, it was seen that as the duration of disease increased the sinus extensions were oriented any side ( p = 0.01). There was, however, a significant relationship between the sinus extension direction and dominant hand use. It was observed that the sinus extension direction of the patients who dominantly used their right hands was towards the left, while the sinus extension direction of the patients with dominant left hands was towards the right ( p = 0.04, RR:2.05). Conclusions: The fact that sinus extension directions can change against factors affecting body positions proves to be another factor which shows that pilonidal sinus disease is an acquired disease.
The European Research Journal; doi:10.18621/eurj.738334
Objectives: Dilation of superficial veins and valvular insufficiency cause the common condition, varicose veins (VVs) on the lower extremities. The treatment modalities for VVS include endovascular thermal ablation techniques using laser, steam and radiofrequency, surgery, foam sclerotherapy, which has various adverse effects. N-butyl cyanoacrylate (NBCA) is a relatively novel polymerizating agent that is used for the treatment of VVs. The aim of this study is to evaluate and present the 24 months outcomes results of endovenous NBCA treatment in 116 patients with VV. Methods: This is a prospective study on 116 patients (71 females, 45 males), treated in a single-center between August 2017 and March 2019. NBCA administration (Venablock®, Invamed, Turkey) was carried out with local anesthesia under ultrasound guidance. All patients were scheduled for follow-up evaluation at 2 weeks, 3, 6, 9, 12, and 24 months. Clinical assessment, VCSS, and ultrasound were performed on patients in the follow-up visits. Results: The mean follow-up period was 16.27 ± 5.62 months. The preoperative and postoperative VCSS values were 6.93 ± 2.60 and 2.40 ± 1.12, respectively ( p < 0.0001). The patients with a greater GSV diameter experienced an unfavorable outcome following the NBCA procedure ( p < 0.001). The overall complication rate was 12.9%. The complete occlusion was achieved in 101 (87.0%) patients. Conclusions: The NBCA administration is a safe treatment method for the VVs, and provides a satisfactory occlusion ratio with improved outcomes.
The European Research Journal; doi:10.18621/eurj.748292
Objectives: Central venous catheterization is an important procedure for infants undergoing heart surgery. Ultrasound-guided methods have been shown to decrease failure and complications. The goal of the present study was investigate the effect of anatomical landmark technique during internal jugular vein access in low-weight infants undergoing congenital heart surgery. Methods: A total 98 infants (median age was 16.5 days, median weight was 3275 g) who underwent internal jugular vein catheterization between January 2017 and October 2019 were retrospectively analyzed. All catherizations were performed by a pediatric heart surgeon. Data including demographic characteristics of the infants, success rate, and catheter-related adverse events were recorded. Results: Success rate was 94.9% (n = 93). There were three arterial puncture (3.1%) and hematoma occurred in five patients (5.1%). Central venous catheterization of 78 (79.6%) patients were successful at the first attempt. Conclusions: Our study suggest that landmark technique still seems useful by experienced operators and is safe and effective in infants weighing less than 5 kg undergoing congenital heart surgery.
The European Research Journal, Volume 7, pp 203-208; doi:10.18621/eurj.809340
Objectives: Fournier’s gangrene is an emergency surgical disease which develops and progresses rapidly and there is high risk of mortality with a delay in diagnosis and treatment. The objective of this study is to investigate the impact of vacuum-assisted closure on the clinical outcome in the treatment of Fournier’s gangrene. Methods: A total of 28 patients diagnosed as Fournier’s gangrene and admitted to our hospital from January 2010 to December 2018 are included in this retrospective study. The diagnosis was established on the basis of physical examination. Epidemiological data including gender, age, and presence of diabetes mellitus, clinical outcomes including use of vacuum-assisted closure, length of admittance, the number of debridement and other surgical procedures were evaluated retrospectively from the medical records and the hospital treatment registry. Results: There were 16 (57.1%) male and 12 (42.9%) female patients and the mean age of the patients was 59.54 ± 16.76 years. The mean number of debridement was 3.67 ± 1.5 times and the total hospital stay was 26.67 ± 7.7 days for vacuum-assisted closure group (n = 9). The average number of debridement was 4.11 ± 0.94 times and the total hospital stay was 31.58 ± 6.33 days for the rest of the patients (n = 19). Conclusions: The average number of debridement and hospital stay were lower in patients treated with vacuum-assisted closure. We also observed an increase in patient comfort and the workload of the stuff is decreased as there was less exudate in the vacuum-assisted closure group.
The European Research Journal; doi:10.18621/eurj.811379
Objectives: The aim of this study is to determine the incidence of intraoperative awereness (IA) in our patients who underwent laparoscopic sleeve gastrectomy (LSG) and the factors affecting the formation of this complication. Methods: Four hundred ten patients who underwent LSG between March 2018 and September 2020 were included in the study. By April 2019, we started using the Bispectral index (BIS) monitoring, which measures the depth of anesthesia in all of our LSG cases (n = 167). Patients with and without BIS monitorization were divided into two groups and compared. Results: In our series, IA was seen in 3 patients (2 males) in two different hospitals (0.7%; n = 410). They were all in the non BIS group (n = 243). The median duration of anesthesia was 120 minutes (ranging 90-180) in the non-BIS, and 113 minutes (ranging, 90-140) in the BIS group ( p < 0.001). Hypotension developed in 63 patients in non-BIS and 12 patients in BIS group at the beginning of the operation (< 90/60 mm Hg). The total remifentanil infusion dose administered during the anesthesia period in the BIS group was 1310 ± 351 mcg, and 1330 ± 270 mcg in the non BIS group ( p = 0.002). The effect of BIS monitorization between groups on IA, did not show statistical significance ( p = 0.27). Conclusions: Anesthesia techniques that work well for patients with normal weight may not be safe and appropriate for obese patients. Especially in patients with intraoperative hypotension, it is necessary to be more careful about dose adjustment of anesthetic drugs.
The European Research Journal; doi:10.18621/eurj.780801
Objectives: Since the introduction of laparoscopic nephrectomies, laparoscopic surgeries in the field of urology have become increasingly popular. Laparoscopic surgery has its advantages but carries the risk of complications like all interventions. In our study, we aimed to discuss our complication rates according to difficulty level by presenting our experiences with urological laparoscopic procedures for the upper urinary system. Methods: This retrospective study includes 942 laparoscopic urological procedures performed by a single surgeon. The procedures divided into three groups according to the European Scoring System (ESS) Classification. The complication rate of each group was calculated separately. Results: A total of 127 (13.4%) complications were observed. Partial nephrectomy, nephroureterectomy and ureterolithotomy had the highest complication rates. Renal cyst excision, simple nephrectomy and radical nephrectomy had the lowest complication rates. According to the Clavien Complication Classification, the distributions of Grade 1, 2 and 3 complications were 29.1% (n =37), 57.4% (n = 73) and 13.3% (n = 17); respectively. The open conversion rate was 0.84%. When procedures were classified as “easy”, “difficult” and “very difficult” according to the ESS classification; complication rates were found 7.3% in the easy group, 13.3% in the difficult group and 16.6% in the very difficult group. There was no significant difference between the three groups in terms of complication rates ( p = 0.329). Conclusions: Performing easier operations according to ESS in the first years of the learning curve is beneficial in preventing complications. With increasing experience, more complicated procedures can be performed with similar complication rates.
The European Research Journal; doi:10.18621/eurj.776229
Objectives: This study aimed to investigate the significance of publications examining the effectiveness of education methods in the field of anatomy with the method of bibliometric and altmetric analysis, as well as online attention levels. Methods: To search all publications, “Anatomy education” was entered as a search term on the Web of Science database. The topics, journal impact factors, publication years and research centers of the first 100 articles with the highest numbers of citations were examined, and their analysis was conducted with the “Altmetric it on website: http: almetric.com”. Results: Four thousand, three hundred fifty-six articles published in the period of 1975-2019 containing the key phrase “Anatomy education” were found on Web of Science. The study with the highest number of citations was the study published by McLachlan et al. titled “Teaching anatomy without cadavers, 2004”. It was observed that the study titled “The production of anatomical teaching resources using three-dimensional (3D) printing technology, 2014” was the article with the highest rate of sharing on Twitter with the highest altmetric attention score (AAS) value. The AAS rates varied between 130 and 0. Conclusions: Bibliometric and altmetric analysis provides significant but different points of view regarding the effects of an article in the world of science. The altmetrics score may provide contributions in determining the direction of studies regarding the high-level interests and perceptions of the public on dynamic science and the field of medicine.
The European Research Journal; doi:10.18621/eurj.775245
Objectives: In patients who do not respond to medical treatment with idiopathic premature ventricular complex (PVC), catheter ablation is performed using the electroanatomic mapping (3D EAM) system for ablation. The aim of this study is to evaluate the acute and long-term success of patients and the procedural features and complication results associated with PVC localization in patients who underwent catheter ablation in our center. Methods: Two hundred seventeen patients who underwent activation mapping and ablation using 3D EAM for PVC were included in the study. Patients were followed up for acute procedure success, periprocedural complications, and six-month long-term recurrence. In addition, these parameters, PVC’s were evaluated in three groups as right ventricular outflow tract (RVOT), coronary cusp and rare localized origin, and clinical outcomes and interventional variables related to the success of the PVC’s location were compared. Results: In our study, the mean age of the patients was 43 ± 12.1 years and the female gender ratio was 37.8%. When catheter ablated PVC foci were evaluated, it is seen that 81 (37.3%) were from RVOT and 56 (25.8%) were from coronary cusp. In addition, 6 (2.8%) were aortomitral continuity, 22 (10.1%) were left ventricular summit/epicardial, 17 (7.8%) were parahisian, and total 80 (36.8%) were rare localized PVCs. Acute procedure success was 92.6% and long-term procedure success was 83% in all cases. When the patients in our study were analyzed according to their PVC locations and procedure successes, those with rare localization compared to those with RVOT and coronary cusp origin were 66 (87.5%), 79 (96.3%), and 53 (94.6%); respectively ( p = 0.03) and long-term successes were 58 (72.5%), 73 (90.1%), and 49 (87.5%); respectively ( p < 0.05). Long-term transaction success was lower. Conclusions: Frequent PVCs can be treated with electroanatomic mapping and radiofrequency ablation with high success rate and low complication rate. Patients with RVOT and coronary cusp-derived PVC had a high acute and long-term success rate, while success rates were lower in rare localized PVCs from epicardial/summit, papillary muscle, parahisian and tricuspid-mitral anulus.
The European Research Journal; doi:10.18621/eurj.721956
Objectives: To determine the correlations between the measurements obtained with Heidelberg retina tomograph III (HRT III), optic coherence tomography (OCT), and laser polarimetry (GDx) with the indices of automated perimetry (AP) in moderate and severe glaucoma patients. Methods: Forty-nine eyes of 30 patients were included in the current study and were divided into two groups: 23 eyes with moderate and 26 eyes with severe glaucoma defined by Hodapp-Parrish-Anderson grading system. Pearson’s correlation coefficients were used to evaluate the correlation between the indices of AP including mean deviation (MD) and pattern standard deviation (PSD), and structural parameters of the retinal nerve fiber layer (RNFL) and optic disc acquired by using three devices in both groups. Results: In moderate glaucoma OCT and GDx measurements were not correlated to MD only the exception of inferior RNFL (r = 0.57, p = 0.007 and r = 0.52, p = 0.008, respectively). Mild to moderate correlations were calculated between the structural parameters of HRT III and AP indices. In severe glaucoma, the most correlated measurements were obtained by OCT compared to the other devices. The correlations for MD were more powerful compared to PSD. Parameters based on the study of the RNFL showed stronger correlations than those of the optic nerve head. No devices showed significant correlations in patients with MD less than -12 dB. Conclusions: OCT measurements showed the best correlations with the AP indices in both moderate and severe glaucoma patients. However, AP still seems to be more effective in the follow-up of glaucoma progression in more advanced glaucomatous damage.