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Yance Anas, Ika Nilam Cahyani, Ulum Firnanda Sukma
Jurnal Ilmu Farmasi dan Farmasi Klinik, Volume 18, pp 1-7; https://doi.org/10.31942/jiffk.v18i01.4893

Abstract:
Previous studies accomplished that the chayote ethanol extract (Sechium edule (Jack) Sw) had an antihypertensive effect. To get and identify the active compound, we fractionated the extract and evaluated its antihypertensive activity. This study aims to investigate the antihypertensive effect of the n-hexane fraction (HF-CEE) and ethyl acetate fraction of chayote ethanol extract (EAF-CEE) in monosodium glutamate (MSG)-induced hypertensive rats. We made the chayote extract using the maceration method by soaking the chayote simplicia in ethanol 70%. HF-CEE and EAF-CEE were obtained by stratified fractionation using n-hexane and ethyl acetate. An antihypertensive effect of the fraction measured on MSG-induced hypertension male Wistar rats after MSG 100 mg/kg BW/day (p.o) treatment for 14 days. The study concluded that HF-CEE and EAF-CEE had an antihypertensive effect in MSG-induced hypertensive rats. The EAF-CEE antihypertensive effect is higher than HF-CEE. Therefore, the FEAF-CEE active compounds need to be isolated, identified, developed, and their potential as an antihypertensive candidate. Keywords: Antihypertensive, chayote, ethyl-acetate fraction, Sechium edule, monosodium glutamate
Daftar Isi
Jurnal Ilmu Farmasi dan Farmasi Klinik, Volume 18; https://doi.org/10.31942/jiffk.v18i01.4891

Abstract:
Jurnal Ilmu Farmasi & Farmasi Klinik Journal of Pharmaceutical Science & Clinical Pharmacy Pemimpin Umum/ Penanggung jawab Dekan Fakultas Farmasi Universitas Wahid Hasyim Pemimpin Redaksi Ketua Program Studi Farmasi Fakultas Farmasi Universitas Wahid Hasyim Dewan Penyunting Jurnal Dr. Yulias Ninik W., M.Si., Apt. Redaktur Ahli Dr. Ahmad Ainur Rofiq, M.Si., Apt. (Universitas Sebelas Maret), Burhan Ma’arif Zaenal Arifn, M.Farm. Apt. (UIN Maulana Malik Ibrahim), Dr. Isnaeni, M.S., Apt. (Universitas Airlangga), Kuni Zu’aimah Barikah, M.Farm., Apt. (Universitas Jember), Dr. Nurkhasanah, M.Si., Apt. (Universitas Ahmad Dahlan), Khoerul Anwar, M.Sc., Apt. (Universitas Lambung Mangkurat), Dr. Gunawan Pamudji Widodo, M.Si., Apt. (Universitas Setia Budi), Dr. Laela Hayu Nurani, M.Si., Apt. (Universitas Ahmad Dahlan), Dr. Iis Wahyuningsih, M.Si., Apt. (Universitas Ahmad Dahlan), Dr. Wahyu Widyaningsih, M.Si., Apt. (Universitas Ahmad Dahlan), Muhammad Ikhwan Rizki, M.Farm., Apt. (Universitas Lambung Mangkurat), Dr. Yulias Ninik W., M.Si., Apt. (Universitas Wahid Hasyim), Maulita Cut Nuria, M.Sc., Apt. (Universitas Wahid Hasyim), Yance Anas, M.Sc., Apt. (Universitas Wahid Hasyim), Risha Fillah Fithria, M.Sc., Apt. (Universitas Wahid Hasyim), Aqnes Budiarti, S.F..Sc., Apt. (Universitas Wahid Hasyim), Ririn Lispita Wulandari, M.Si.Med., Apt. (Universitas Wahid Hasyim), Maria Ulfah, M.Sc., Apt. (Universitas Wahid Hasyim), Elya Zulfa, M.Sc., Apt. (Universitas Wahid Hasyim), Anita Dwi Puspitasari, S.Si., M.Pd. (Universitas Wahid Hasyim), Dewi Andini Kunti Mulangsri, M.Farm., Apt. (Universitas Wahid Hasyim), Devi Nisa Hidayati, M.Sc., Apt (Universitas Wahid Hasyim), M. Fatchur Rochman, M.Farm. (Universitas Wahid Hasyim), Malinda Prihantini, M.Si., Apt. (Universitas Wahid Hasyim) Redaktur Pelaksana Elya Zulfa, S.Farm., M.Sc., Apt Staf Redaksi : Dewi Andini Kunti Mulangsri, M.Farm., Apt. Ririn Lispita W., S. Farm., M.Si.Med, Apt. Devi Nisa Hidayati, M.Sc., Apt Danang Novianto, S.Farm., Apt Erika Indah Safitri, M.Farm. Imam Asrofi, S.Farm. Distributor Fahmi Wildasani, A.Md Alamat Redaksi/Tata Usaha Fakultas Farmasi Universitas Wahid Hasyim Jl. Menoreh Tengah X/22 Sampangan Semarang Telp. 024-8505680, 8505681 Fax. 024-8505680 E-mail : [email protected] Terbit 2 kali setahun sejak September 2004
Sri Haryanti, Zullies Ikawati, Mustofa Mustofa, Tri Murti Andayani
Jurnal Ilmu Farmasi dan Farmasi Klinik, Volume 18, pp 8-15; https://doi.org/10.31942/jiffk.v18i01.4894

Abstract:
To produce an effect, the agonist drug 2 will bind to the ADRB2 receptor. The effect of agonist 2 shows variation between individuals due to the presence of encoding gene polymorphisms. There are 80 ADRB2 polymorphisms, including Arg16Gly in amino acids 16. The innate ADRB2 genotype is called wildtype, whereas mutated ones is called mutant. The purpose of this study was to determine whether there was a relationship between genotype rs 1042713 (Arg16Gly) and the effectiveness of β2-agonist drugs in asthma sufferers. This study was an observational study with a cross sectional design and prospective data collection. Examination of the presence of gene polymorphisms and assessment of effe A total of 101 asthma patients who met the inclusion criteria were sorted by genome type by pharmacogenomic examination uses the Asthma Control Test (ACT) questionnaire. The results of the statistical test with chi square to determine the relationship of genome type and asthma control obtained p value 0.131. The comparison of the effectiveness of the wildtype genome is more effective than the mutant of 1.887x, and heterozygote is more effective 1,667x greater than the mutant. There is no significant relation between genotypes rs 1042713 (Arg16Gly) with effectiveness, but the possibility of clinical effectiveness is different. Keywords: Asthma, β2-agonist, ADRB2, genotype, effectiveness.
Pengantar Redaksi
Jurnal Ilmu Farmasi dan Farmasi Klinik, Volume 18; https://doi.org/10.31942/jiffk.v18i01.4892

Abstract:
Assalamualaikum Wr.Wb Alhamdulillah seiring dengan perjalanan Fakultas Farmasi Universitas Wahid Hasyim Semarang, Jurnal Ilmu Farmasi dan Farmasi Klinik (JIFFK) telah memasuki tahun ke-17 semenjak penerbitan perdana tahun 2004. Kami tetap berharap bahwa JIFFK dapat memberikan kontribusi bagi perkembangan ilmu farmasi dan farmasi klinik. Kami berharap bahwa JIFFK ini dapat digunakan sebagai wadah bagi para peneliti, akademisi dan pemerhati ilmu farmasi dan farmasi klinik untuk mempublikasikan hasil penelitian atau pemikirannya. Demi menjaga eksistensi dan sustainabilitas JIFFK kami senantiasa memohon sumbangan tulisan atau artikel dari para peneliti. Kami selalu berusaha untuk dapat meningkatkan kualitas dari setiap penerbitan JIFFK ini, karena kami memiliki cita-cita supaya JIFFK dapat terakreditasi dari dikti. Akhir kata kami sampaikan terima kasih yang sebesar-besarnya kepada semua pihak yang telah membantu terlaksananya penerbitan ini. Kritik dan saran kami nantikan dari pembaca sekalian demi perbaikan dan kemajuan JIFFK. Wassalamu’alaikum Wr. Wb Semarang, Juni 2021 Hormat Kami Redaksi
Weni Puspita, Heny Puspasari
Jurnal Ilmu Farmasi dan Farmasi Klinik, Volume 18, pp 24-30; https://doi.org/10.31942/jiffk.v18i01.4896

Abstract:
Premna serratifolia L. leaves contain flavonoids, saponins, polyphenols, and terpenoids, potentially act as sunscreens. The purpose of this study was to determine the flavonoid content and SPF (Sun Protection Factor) ethanol extract of Premna serratifolia L. leaves from Melawi Regency, West Kalimantan Province using UV-Vis spectrophotometer. The Premna serratifolia L. leaves were extracted by maceration using 70% ethanol solvent, then the filtrate obtained was concentrated with a rotary vacuum evaporator to obtain a thick extract. The extract was determined for its flavonoid content using UV-Vis spectrophotometer at a wavelength of 439 nm, and the SPF value was determined at a concentration of 25, 50, 75, and 100 ppm with a UV-Vis spectrophotometer at a wavelength of 290-320 nm. The SPF value was calculated and analyzed descriptively using the Mansur method. The result showed that the average flavonoid content of ethanol extract of Premna serratifolia L. leaves was 3.70±0.02% calculated as quercetin. The SPF EEDB values obtained from variations in concentrations of 25, 50, 75, and 100 ppm respectively were 19.95±0.02; 30.08±0.01; 34.58±0.14; and 38.28 ± 0.12, where the SPF value is included in the ultra protection category. Key words: Premna serratifolia L. leaves, flavonoid content, SPF, UV-Vis Spectrophotometer
Marwin Marwin, Dyah Aryani Perwitasari, Susan Fitri Candradewi, Bayu Prio Septiantoro, Fredrick Dermawan Purba
Jurnal Ilmu Farmasi dan Farmasi Klinik, Volume 18, pp 16-23; https://doi.org/10.31942/jiffk.v18i01.4895

Abstract:
Breast cancer is the most common cancer found in women and is the dominant cancer in Indonesia. Cancer treatments such as chemotherapy can affect the quality of life of patients including physical, psychological, and social. The purpose of this study is to measure the quality of life of breast cancer patients. This research used cross sectional study design. The patient quality of life was measured using the EORTC QLQ-C30 questionnaire. The subjects of this study were breast cancer patients in RSUP Dr. Kariadi Semarang meeting the inclusion criteria. The cognitive function domain, social function, emotional function, role function, and physical function were 86,15 ± 17,82; 84,10 ± 21,13; 82,56 ± 17,72; 77,95 ± 29,77; 76,72 ± 22,95, respectively. Whereas in symptom scale group from pain, fatigue, insomnia, appetite loss, financial difficulties, nausea and vomiting, constipation, dyspnea and diarrhea were 32,82 ± 30,33; 32,65 ± 21,14; 31,79 ± 34,58; 31,79 ± 32,51; 30,77 ± 32,44; 23,59 ± 25,67; 17,95 ± 30,9; 4,62 ± 14,28; 4,10 ± 13,83, respectively. For global health status / quality of life obtained 72.18 ± 18.94. The highest score on the functional scale is the cognitive function domain and the lowest score is the physical function.On the scale of symptom the domain that has the highest score is the pain domain and the lowest score is the diarrhea domain. Keywords: quality of life, breast cancer, EORTC QLQ-C30
Septiana Laksmi Ramayani, Eka Amalia Permatasari, Indah Novitasari, Maryana Maryana
Jurnal Ilmu Farmasi dan Farmasi Klinik, Volume 18, pp 40-46; https://doi.org/10.31942/jiffk.v18i01.4898

Abstract:
Excessive Reactive Oxygen Species (ROS) can cause hypertension. Prevention of the risk of hypertension is consume an antioxidant. Noni (Morinda citrifolia L). is a plant that empirically proven to lower blood pressure and has antioxidant activity. Antihypertensive activity of noni leaves is influenced by phenolic and flavonoid compounds. The extraction method affects the levels of compound in extracts. The aims of study is determine the effect of the extraction method on the total phenolic level, total flavonoid level and antioxidant activity of noni leaf extract. The extraction methods are maceration, Microwave Assisted Extraction and Soxhlet. The results showed that the different extraction methods affected the total phenol level, total flavonoid level and antioxidant activity of the noni leaf extract. The Soxlet method provides the highest total phenolic level, total flavonoid level and antioxidant activity than other extraction methods. Keywords: Noni leaf extract, extraction method, total phenolic level, total flavonoid level and antioxidant activity
Seri Agustini, Sari Wijayanti, Irma Novrianti
Jurnal Ilmu Farmasi dan Farmasi Klinik, Volume 18, pp 31-39; https://doi.org/10.31942/jiffk.v18i01.4897

Abstract:
The plant that is believed by the public as a medicinal plant is Globe Amarant (Gomprena globosa L) which allegedly contains flavonoids and saponins compounds that can modulate wound healing acceleration. The flower has been shown to have an effect on wound healing in test animals, but so far there has been no research on the effectiveness of the knob flower on burns. Therefore, this study aims to identify the content of flavonoids and saponins in Kenop flowers and to see the effectiveness of healing burns in rabbits. The design of this study was an experimental study that used 5 groups of test animals, namely 2 control groups, and 3 groups of Kenop flower extract. Burn induction was performed using a 2x2 plate. The length of the wound was measured every 2 days using a caliper. Meanwhile, the identification test of flavonoid and saponin compounds was carried out using the forth and wilstatter methods. Based on the results of the study, it was found that the ethanol extract of the Kenop flower contains flavonoid and saponin compounds. The effectiveness test of the Knob flower extract on burns showed that the 30% extract group showed 92% wound healing with a wound diameter on the 14th day of 0.16; followed by a 20% extract group with a wound healing percentage of 84.3% with a wound diameter of 0.31 cm. The ethanol extract of the flower of the Kenop flower can heal burns at that concentration. Keywords: Kenop Flower, Flavonoids, Burns
Mar’Atus Sholikhah, Rahayu Apriyanti
Jurnal Ilmu Farmasi dan Farmasi Klinik, Volume 16, pp 99-104; https://doi.org/10.31942/jiffk.v16i02.3233

Abstract:
Alpinia galanga (L.) Sw or galangal is widely used by Indonesian people as a spice in cooking. The content of catechins and 1-acetoxicavicol acetate in the extract is known to have antioxidant activity. The ability of these antioxidants needs to be applied to pharmaceutical dosage forms to improve aesthetics and ease of use. One of the topical drug delivery systems that is in accordance with the needs of the community today is the preparation of peel-off gel mask. The purpose of this study was to determine the effect of variations in PVA gelling agent concentration as a mask base on the physical characteristics of galangal extract peel-off gel masks. Three mask formulations were made based on variations in the concentration of PVA in the range of 5% -15%. The physical characterization of the preparations included organoleptic tests, homogeneity, pH, viscosity, adhesion, dispersion, and drying time. Homogeneity and organoleptic parameters were analyzed descriptively. The parameters of viscosity, drying time, pH, spreadability, and adhesion were analyzed statistically using Anova Single Factor with a confidence level of 95%. The results showed that the F1 and F2 formulas with PVA concentrations of 10% and 12.5% were the optimum formulas as a mask base. Based on statistical tests, variations in the concentration of PVA significantly influence the parameters of mask adhesion with a p-value of 0.0001 (
Fithri Zahara S, Ebta Narasukma A, Maria Caecilia N.S.H
Jurnal Ilmu Farmasi dan Farmasi Klinik, Volume 16, pp 93-98; https://doi.org/10.31942/jiffk.v16i02.3232

Abstract:
Osteoarthritis (OA) is a degenerative joint illness characterized by cartilage destruction and often found on older people. The drugs commonly used to treat OA symptoms is paracetamol, nonsteroidal anti-inflammatory drugs (NSAIDs), food supplements such as glucosamine and chondroitin. The purposes of these studies are identifying the OA patient's characteristics (including gender and age), drug use evaluation based on the right patient, indication, and dose, as well as the potency of drug interactions on OA patients. This research is non-experimental research with a non-analytical descriptive design. The data was collected retrospectively with a purposive sampling method from outpatients OA medical records in RSUD Dr. M. Ashari Pemalang (March to April 2018 period). The results of this study indicate that patients have suffered OA for 1-2 years (40%), generally women (72.94%) with an age range of 46-55 years (39%). Most patients have an elementary school educational background (41%), and 43.53% of them are overweight (BMI 25.00-29.99). All medicines prescribed for OA patient therapy have been the right indication and patient. As many as 80.95% of the prescribed medicines had the right dose, and 19.05% of prescription drugs case categorized as underdosing. Drug interactions potency occurs in 30.58% of patients, with 29 cases. Keywords: Osteoarthritis, drugs use evaluation, outpatient
, Elya Zulfa, Dwara Andriani Astuti
Jurnal Ilmu Farmasi dan Farmasi Klinik, Volume 16, pp 139-148; https://doi.org/10.31942/jiffk.v16i02.3239

Abstract:
The ethanol extract of guava leaves (EEGL) is proven to heal various types of wounds.This study aims to determine the physicochemical characteristics of the EEGL ointment with a hydrocarbon base formula and examine the effect of the ointment against cut wounds on wistar male rat. The EEGL was obtained by maceration using 70% ethanol solvent. The ointment made 3 formulas with a ratio of hydrocarbon base composition (cera alba:vaselin album) namely F1 (2.5:92.5)%; F2 (5:90)%; F3 (7.5:87.5)%. The physicochemical characteristics of all ointments examined included organoleptic, homogeneity, pH, viscosity, spreadability, and adhesion. Organoleptic, homogeneity and pH data were analyzed descriptively, while viscosity, spreadability and adhesion data were analyzedstatistically. Testing the effect of all ointment formulas on the wound was done by applying 0.5 gram 2x a day for 9 days compared to wound control without treatment and positive control used commercial product.The parameter of effect measured was the length of the cut wound on the 9th day, then analyzed with the Kruskall Wallis test followed by the Mann Whitney test.The physicochemical characteristics of EEGL ointment (F1, F2, F3) are known that all ointment formulas are brown in color, typical of guava, homogeneous, pH according to skin pH, viscosity and adhesion are significantly different, while the spredability is not significant.The EEGL ointment had an effect on the cut wound of the male wistar rats, ie the length of the wound on the 9th day was reduced and compared to wound controlwas differentsignificantly. Keywords :Guava leaves, ointment, cut of wound.
, Elya Zulfa, Listyana Dewi Prastiwi, Ikha Dyah Yulianti
Jurnal Ilmu Farmasi dan Farmasi Klinik, Volume 16, pp 125-133; https://doi.org/10.31942/jiffk.v16i02.3237

Abstract:
The nanoparticle system encapsulates and protects flavonoids of suji leaves from photolysis and oxidation instability. Chitosan is a biocompatible, biodegradable and non-toxic nanoparticles forming polymer. Ultrasonication is a materials mixing technique under high vibration energy. The ultrasonication time affects the particle size. The aim of this study was to determine the effect of the ultrasonication time on physical characteristics of chitosan nanoparticles of suji (Pleomele angustifolia) leaf ethanol extract and its physical stability after cycling test. Ethanol extract of suji leaves (EEDS) was obtained by maceration using 70% ethanol. Chitosan EEDS nanoparticles were made under ionic gelation method using an ultrasonication time of 3 minutes (FI), 6 minutes (FII), and 9 minutes (FIII). The physical characterization of nanoparticles includes particle size, polydispersity index, and zeta potential. Chitosan EEDS nanoparticles with the best physical characteristics (FIII) were tested for stability using cycling test method. The data obtained were analyzed using the Anova statistical method with a 95% confidence level. The size of EEDS chitosan nanoparticles (nm) was significantly different in all formulas, FI (374.47), FII (288.43), and FIII (233.37). The polydispersity index of FI (0.38) and FIII (0.65) were significantly different, while FII (0.41) was not significantly different. The zeta potential (mV) FI (51.70), FII (46.10), and FIII (48.60) were not significantly different in all formulas. The physical characteristics of Formula III after Cycling Test showed a particle size of 455.0 nm, a polydispersity index of 0.174, and a zeta potential of 20.1 mV. Keywords: ultrasonication, nanoparticles, chitosan, cycling test, suji leaf (Pleomele angustifolia)
Maria Mita Susanti, Syela Puspitaningtyas
Jurnal Ilmu Farmasi dan Farmasi Klinik, Volume 16, pp 111-118; https://doi.org/10.31942/jiffk.v16i02.3235

Abstract:
The free radicals exposure from daily activities can cause the damage the skin, therefore to avoid this damage effect can use antioxidants compounds . Brown rice bran is rice milling waste which has high antioxidant with IC50 is 43,2349 ppm. Efforts to increase the economic value of rice bran high in antioxidant compounds is by processing rice bran into transparent soap products. This research was conducted to analyze the quality characteristics of transparent red rice bran soap (Oryza nivara) based on used cooking oil. The quality characteristics of transparent rice soap which includes organoleptic soap, pH, foam power, free alkali, and water content. The data were analyzed descriptively by comparing the results of research with SNI 06-3532 -1994 Based on the results of the study obtained the results of the characteristics of soap that meets the quality characteristics of SNI 06-3532-1994 soap requirements with a pH of 10,2 , foam power of 2,54 cm, free alkali of 0,034%, and 3,85% moisture content. Keywords : transparent soap, brown rice bran, used cooking oil, solid soap quality characteristics
, Regina Andayani, Aulia Rahmi, Wida Ningsih
Jurnal Ilmu Farmasi dan Farmasi Klinik, Volume 16, pp 134-138; https://doi.org/10.31942/jiffk.v16i02.3238

Abstract:
Whitening lotion is a mixture of chemicals or other ingredients with properties that can whiten the skin or blemish black (brown) on the skin. The use of mercury in whitening lotions can cause a variety of things, ranging from skin discoloration which can ultimately cause black spots on the skin, allergies and skin irritation. The using of mercury in high dose can cause permanent brain damageand cancer. An analysis of mercury content in the whitening lotion brands A, B and C circulating at market in Padang city has been conducted. Extraction of mercury in the whitening lotion was done by wet destruction with a concentrated HNO3 solution and concentrated H2SO4 for 2 hours at a temperature of ± 95°C until a clear solution is obtained. The clear solution was measured by absorption with an Atomic Absorption Spectrophotometer using a mercury hollow cathode lamp at a wavelength of 253.7 nm. The results of this study were samples of brands A, B and C detected containing mercury metals with successive levels of 0.3347 μg /g; 0,7917 μg /g and 0,7981 μg/ g. The whitening lotions that circulate in market do not meet the Head of BPOM RI Regulation No.18 of 2015 whose contents prohibit the use of mercury in cosmetics preparations. Keywords: mercury, whitening lotion, Atomic Absorption Spectrophotometer
, Dhia Salsabilla, Evi Sukawati
Jurnal Ilmu Farmasi dan Farmasi Klinik, Volume 16, pp 105-110; https://doi.org/10.31942/jiffk.v16i02.3234

Abstract:
The chemicals contained in an extract must be maintained its quality. The aim of this study is to prove both that the ethanol extract of kecapi (Sandoricum koetjape, Merr.) and keluwih (Artocarpus communis) leaves meet the non-specific parameters on the standardization of the extract. The ethanol extract of kecapi and keluwih leaves were extracted using the ultrasonic method. The extract was tested with non-specific parameters including water content, total ash content and metal contamination level. The test results are compared with standard parameter references. Ethanol extract of kecapi leaf have water content of 27.75% ± 1.708, total ash content of 4.856% ± 0.040 and levels of As metal contamination < 0.030 mg/Kg, Hg < 0.002 mg/Kg, Pb < 0.400 mg/Kg, while ethanol extract of keluwih leaf have water content of 23.206 ± 0.091%, total ash content of 9,678 ± 0.306% and levels of heavy metal contamination of As < 0.03 mg/Kg, Hg < 0.006 mg/Kg, Pb < 0.02 mg/Kg. The both extract meet the standard parameters of water content, total ash content and levels heavy metal contamination. Key words: kecapi leaves (Sandoricum koetjape, Merr.), keluwih leaves (Artocarpus communis), non-specific standardization
Margareta Retno Priamsari, Rina Ayu Krismonikawati
Jurnal Ilmu Farmasi dan Farmasi Klinik, Volume 16, pp 86-92; https://doi.org/10.31942/jiffk.v16i02.3231

Abstract:
Inflammation is a normal response to injury due to release of chemical mediators such as prostaglandins. Solanum betaceum Cav. skin contains flavonoid compounds. This study aims to determine the antiinflammatory power and the effect of variations in the dose of ethanolic extract of the skin of Solanum betaceum Cav on Swiss male strain mice caragenin-induced. The ethanolic extract of Solanum betaceum Cav skin was obtained using remaseration method with 96% ethanol solvent. Antiinflammatory power test using edema formation method with induction of caragenin 1% intraplantar 30 minutes before administration of the test material. Tests were carried out on 25 mice records which were divided into 5 groups namely negative control (0.5% CMC Na suspension), positive control (diclofenac sodium suspension in 0.5% CMC Na dose 7 mg/kgBW) and given suspension respectively. Dutch eggplant skin ethanolic extract in CMC Na 0.5% dose 70 mg/kgBW; 140 mg/kgBW; 280 mg/kgBW orally. The parameters observed were edema thickness measured using calipers at 30 minute intervals for 360 minutes. The results of edema thickness difference are used to calculate the Area Under Curve (AUC) and the percentage of antiinflammatory power (% AIP). Dat a were analyzed statistically with the One Way Anova test and continued by the Post Hoc Test with a 95% confidence level. The results showed that the ethanolic extract of Solanum betaceum Cav skin contains flavonoid compounds and has antiinflammatory power. The greater the dose of ethanolic extract of Solanum betaceum Cav skin, the greater the anti-inflammatory power. Keywords: Solanum betaceum Cav., antinflammation, caragenin
, Heru Fitranto, Yana Astiana, Mufrod Mufrod
Jurnal Ilmu Farmasi dan Farmasi Klinik, Volume 16, pp 119-124; https://doi.org/10.31942/jiffk.v16i02.3236

Abstract:
Breadfruit leaves (Artocarpus altilis) was contain compound of flavonoids, tannins and phenol that the ability as antibacterial against Staphylococcus aureus bacteria. The extracts of breadfruit leaves formulated became ointment that made practice to used. The combine of ointment bases can obtain of good consistency like the combine of adeps lanae with vaselin album and cera flava with vaselin album. The aims of this study to know the profile of antibacterial activity of the breadfruit leaves extract ointment with two kind of the combine of ointment bases. The breadfruit leaves extract has obtained by maceration method used etanol 70% solvents. The breadfruit leaves ointment was made by melting method with combination bases A is adeps lanae:vaselin album as F1 (13.5%:76.5%), F2 (45%:45%) dan F3 (76.5%:13.5%), while combination B is cera alba:vaselin album as F1 (85.5%:4.5%), F2 (81%:9%), F3 (76.5%:13.5%). antibacterial activity assay was used well diffusion method and analyzed descriptively. The research result that the all formulas has breadfruit flavor, smooth texture and brown color. Two variatons of combination bases ointment has antibacterial activity against Staphylcoccus aureus bacteri with formed of inhibition zone around the well. Keywords: Breadfruit leaves extract, ointment, antibacterial, combination of ointment bases
Maria Mita Susanti, Syela Puspitaningtyas
Jurnal Ilmu Farmasi dan Farmasi Klinik, Volume 16, pp 26-33; https://doi.org/10.31942/jiffk.v16i02.3124

Abstract:
The free radicals exposure from daily activities can cause the damage the skin, therefore to avoid this damage effect can use antioxidants compounds . Brown rice bran is rice milling waste which has high antioxidant with IC50 is 43,2349 ppm. Efforts to increase the economic value of rice bran high in antioxidant compounds is by processing rice bran into transparent soap products. This research was conducted to analyze the quality characteristics of transparent red rice bran soap (Oryza nivara) based on used cooking oil. The quality characteristics of transparent rice soap which includes organoleptic soap, pH, foam power, free alkali, and water content. The data were analyzed descriptively by comparing the results of research with SNI 06-3532 -1994 Based on the results of the study obtained the results of the characteristics of soap that meets the quality characteristics of SNI 06-3532-1994 soap requirements with a pH of 10,2 , foam power of 2,54 cm, free alkali of 0,034%, and 3,85% moisture content. Keywords : transparent soap, brown rice bran, used cooking oil, solid soap quality characteristics
, Heru Fitranto, Yana Astiana, Mufrod Mufrod
Jurnal Ilmu Farmasi dan Farmasi Klinik, Volume 16, pp 34-39; https://doi.org/10.31942/jiffk.v16i02.3125

Abstract:
Breadfruit leaves (Artocarpus altilis) was contain compound of flavonoids, tannins and phenol that the ability as antibacterial against Staphylococcus aureus bacteria. The extracts of breadfruit leaves formulated became ointment that made practice to used. The combine of ointment bases can obtain of good consistency like the combine of adeps lanae with vaselin album and cera flava with vaselin album. The aims of this study to know the profile of antibacterial activity of the breadfruit leaves extract ointment with two kind of the combine of ointment bases. The breadfruit leaves extract has obtained by maceration method used etanol 70% solvents. The breadfruit leaves ointment was made by melting method with combination bases A is adeps lanae:vaselin album as F1 (13.5%:76.5%), F2 (45%:45%) dan F3 (76.5%:13.5%), while combination B is cera alba:vaselin album as F1 (85.5%:4.5%), F2 (81%:9%), F3 (76.5%:13.5%). antibacterial activity assay was used well diffusion method and analyzed descriptively. The research result that the all formulas has breadfruit flavor, smooth texture and brown color. Two variatons of combination bases ointment has antibacterial activity against Staphylcoccus aureus bacteri with formed of inhibition zone around the well. Keywords: Breadfruit leaves extract, ointment, antibacterial, combination of ointment bases
Fithri Zahara S., Ebta Narasukma A., Maria Caecilia N.S.H
Jurnal Ilmu Farmasi dan Farmasi Klinik, Volume 16, pp 8-13; https://doi.org/10.31942/jiffk.v16i02.3121

Abstract:
Osteoarthritis (OA) is a degenerative joint illness characterized by cartilage destruction and often found on older people. The drugs commonly used to treat OA symptoms is paracetamol, nonsteroidal anti-inflammatory drugs (NSAIDs), food supplements such as glucosamine and chondroitin. The purposes of these studies are identifying the OA patient's characteristics (including gender and age), drug use evaluation based on the right patient, indication, and dose, as well as the potency of drug interactions on OA patients. This research is non-experimental research with a non-analytical descriptive design. The data was collected retrospectively with a purposive sampling method from outpatients OA medical records in RSUD Dr. M. Ashari Pemalang (March to April 2018 period). The results of this study indicate that patients have suffered OA for 1-2 years (40%), generally women (72.94%) with an age range of 46-55 years (39%). Most patients have an elementary school educational background (41%), and 43.53% of them are overweight (BMI 25.00-29.99). All medicines prescribed for OA patient therapy have been the right indication and patient. As many as 80.95% of the prescribed medicines had the right dose, and 19.05% of prescription drugs case categorized as underdosing. Drug interactions potency occurs in 30.58% of patients, with 29 cases. Keywords: Osteoarthritis, drugs use evaluation, outpatient
Mar’Atus Sholikhah, Rahayu Apriyanti
Jurnal Ilmu Farmasi dan Farmasi Klinik, Volume 16, pp 14-19; https://doi.org/10.31942/jiffk.v16i02.3122

Abstract:
Alpinia galanga (L.) Sw or galangal is widely used by Indonesian people as a spice in cooking. The content of catechins and 1-acetoxicavicol acetate in the extract is known to have antioxidant activity. The ability of these antioxidants needs to be applied to pharmaceutical dosage forms to improve aesthetics and ease of use. One of the topical drug delivery systems that is in accordance with the needs of the community today is the preparation of peel-off gel mask. The purpose of this study was to determine the effect of variations in PVA gelling agent concentration as a mask base on the physical characteristics of galangal extract peel-off gel masks. Three mask formulations were made based on variations in the concentration of PVA in the range of 5% -15%. The physical characterization of the preparations included organoleptic tests, homogeneity, pH, viscosity, adhesion, dispersion, and drying time. Homogeneity and organoleptic parameters were analyzed descriptively. The parameters of viscosity, drying time, pH, spreadability, and adhesion were analyzed statistically using Anova Single Factor with a confidence level of 95%. The results showed that the F1 and F2 formulas with PVA concentrations of 10% and 12.5% were the optimum formulas as a mask base. Based on statistical tests, variations in the concentration of PVA significantly influence the parameters of mask adhesion with a p-value of 0.0001 (
Margareta Retno Priamsari, Rina Ayu Krismonikawati
Jurnal Ilmu Farmasi dan Farmasi Klinik, Volume 16, pp 1-7; https://doi.org/10.31942/jiffk.v16i02.3120

Abstract:
Inflammation is a normal response to injury due to release of chemical mediators such as prostaglandins. Solanum betaceum Cav. skin contains flavonoid compounds. This study aims to determine the antiinflammatory power and the effect of variations in the dose of ethanolic extract of the skin of Solanum betaceum Cav on Swiss male strain mice caragenin-induced. The ethanolic extract of Solanum betaceum Cav skin was obtained using remaseration method with 96% ethanol solvent. Antiinflammatory power test using edema formation method with induction of caragenin 1% intraplantar 30 minutes before administration of the test material. Tests were carried out on 25 mice records which were divided into 5 groups namely negative control (0.5% CMC Na suspension), positive control (diclofenac sodium suspension in 0.5% CMC Na dose 7 mg/kgBW) and given suspension respectively. Dutch eggplant skin ethanolic extract in CMC Na 0.5% dose 70 mg/kgBW; 140 mg/kgBW; 280 mg/kgBW orally. The parameters observed were edema thickness measured using calipers at 30 minute intervals for 360 minutes. The results of edema thickness difference are used to calculate the Area Under Curve (AUC) and the percentage of antiinflammatory power (% AIP). Dat a were analyzed statistically with the One Way Anova test and continued by the Post Hoc Test with a 95% confidence level. The results showed that the ethanolic extract of Solanum betaceum Cav skin contains flavonoid compounds and has antiinflammatory power. The greater the dose of ethanolic extract of Solanum betaceum Cav skin, the greater the anti-inflammatory power.
, Dhia Salsabilla, Evi Sukawati
Jurnal Ilmu Farmasi dan Farmasi Klinik, Volume 16, pp 20-25; https://doi.org/10.31942/jiffk.v16i02.3123

Abstract:
The chemicals contained in an extract must be maintained its quality. The aim of this study is to prove both that the ethanol extract of kecapi (Sandoricum koetjape, Merr.) and keluwih (Artocarpus communis) leaves meet the non-specific parameters on the standardization of the extract. The ethanol extract of kecapi and keluwih leaves were extracted using the ultrasonic method. The extract was tested with non-specific parameters including water content, total ash content and metal contamination level. The test results are compared with standard parameter references. Ethanol extract of kecapi leaf have water content of 27.75% ± 1.708, total ash content of 4.856% ± 0.040 and levels of As metal contamination < 0.030 mg/Kg, Hg < 0.002 mg/Kg, Pb < 0.400 mg/Kg, while ethanol extract of keluwih leaf have water content of 23.206 ± 0.091%, total ash content of 9,678 ± 0.306% and levels of heavy metal contamination of As < 0.03 mg/Kg, Hg < 0.006 mg/Kg, Pb < 0.02 mg/Kg. The both extract meet the standard parameters of water content, total ash content and levels heavy metal contamination. Key words: kecapi leaves (Sandoricum koetjape, Merr.), keluwih leaves (Artocarpus communis), non-specific standardization
, Regina Andayani, Aulia Rahmi, Wida Ningsih
Jurnal Ilmu Farmasi dan Farmasi Klinik, Volume 16, pp 49-53; https://doi.org/10.31942/jiffk.v16i02.3198

Abstract:
Whitening lotion is a mixture of chemicals or other ingredients with properties that can whiten the skin or blemish black (brown) on the skin. The use of mercury in whitening lotions can cause a variety of things, ranging from skin discoloration which can ultimately cause black spots on the skin, allergies and skin irritation. The using of mercury in high dose can cause permanent brain damageand cancer. An analysis of mercury content in the whitening lotion brands A, B and C circulating at market in Padang city has been conducted. Extraction of mercury in the whitening lotion was done by wet destruction with a concentrated HNO3 solution and concentrated H2SO4 for 2 hours at a temperature of ± 95°C until a clear solution is obtained. The clear solution was measured by absorption with an Atomic Absorption Spectrophotometer using a mercury hollow cathode lamp at a wavelength of 253.7 nm. The results of this study were samples of brands A, B and C detected containing mercury metals with successive levels of 0.3347 μg /g; 0,7917 μg /g and 0,7981 μg/ g. The whitening lotions that circulate in market do not meet the Head of BPOM RI Regulation No.18 of 2015 whose contents prohibit the use of mercury in cosmetics preparations. Keywords: mercury, whitening lotion, Atomic Absorption Spectrophotometer
, Elya Zulfa, Dwara Andriani Astuti
Jurnal Ilmu Farmasi dan Farmasi Klinik, Volume 16, pp 54-63; https://doi.org/10.31942/jiffk.v16i02.3220

Abstract:
The ethanol extract of guava leaves (EEGL) is proven to heal various types of wounds.This study aims to determine the physicochemical characteristics of the EEGL ointment with a hydrocarbon base formula and examine the effect of the ointment against cut wounds on wistar male rat. The EEGL was obtained by maceration using 70% ethanol solvent. The ointment made 3 formulas with a ratio of hydrocarbon base composition (cera alba:vaselin album) namely F1 (2.5:92.5)%; F2 (5:90)%; F3 (7.5:87.5)%. The physicochemical characteristics of all ointments examined included organoleptic, homogeneity, pH, viscosity, spreadability, and adhesion. Organoleptic, homogeneity and pH data were analyzed descriptively, while viscosity, spreadability and adhesion data were analyzedstatistically. Testing the effect of all ointment formulas on the wound was done by applying 0.5 gram 2x a day for 9 days compared to wound control without treatment and positive control used commercial product.The parameter of effect measured was the length of the cut wound on the 9th day, then analyzed with the Kruskall Wallis test followed by the Mann Whitney test.The physicochemical characteristics of EEGL ointment (F1, F2, F3) are known that all ointment formulas are brown in color, typical of guava, homogeneous, pH according to skin pH, viscosity and adhesion are significantly different, while the spredability is not significant.The EEGL ointment had an effect on the cut wound of the male wistar rats, ie the length of the wound on the 9th day was reduced and compared to wound controlwas differentsignificantly. Keywords :Guava leaves, ointment, cut of wound.
, Elya Zulfa, Listyana Dewi Prastiwi, Ikha Dyah Yulianti
Jurnal Ilmu Farmasi dan Farmasi Klinik, Volume 16, pp 40-48; https://doi.org/10.31942/jiffk.v16i02.3139

Abstract:
The nanoparticle system encapsulates and protects flavonoids of suji leaves from photolysis and oxidation instability. Chitosan is a biocompatible, biodegradable and non-toxic nanoparticles forming polymer. Ultrasonication is a materials mixing technique under high vibration energy. The ultrasonication time affects the particle size. The aim of this study was to determine the effect of the ultrasonication time on physical characteristics of chitosan nanoparticles of suji (Pleomele angustifolia) leaf ethanol extract and its physical stability after cycling test. Ethanol extract of suji leaves (EEDS) was obtained by maceration using 70% ethanol. Chitosan EEDS nanoparticles were made under ionic gelation method using an ultrasonication time of 3 minutes (FI), 6 minutes (FII), and 9 minutes (FIII). The physical characterization of nanoparticles includes particle size, polydispersity index, and zeta potential. Chitosan EEDS nanoparticles with the best physical characteristics (FIII) were tested for stability using cycling test method. The data obtained were analyzed using the Anova statistical method with a 95% confidence level. The size of EEDS chitosan nanoparticles (nm) was significantly different in all formulas, FI (374.47), FII (288.43), and FIII (233.37). The polydispersity index of FI (0.38) and FIII (0.65) were significantly different, while FII (0.41) was not significantly different. The zeta potential (mV) FI (51.70), FII (46.10), and FIII (48.60) were not significantly different in all formulas. The physical characteristics of Formula III after Cycling Test showed a particle size of 455.0 nm, a polydispersity index of 0.174, and a zeta potential of 20.1 mV. Keywords: ultrasonication, nanoparticles, chitosan, cycling test, suji leaf (Pleomele angustifolia)
, Ady Laksono Putro, Efa Erfiana Safitri
Jurnal Ilmu Farmasi dan Farmasi Klinik, Volume 16, pp 21-27; https://doi.org/10.31942/jiffk.v16i01.2925

Abstract:
Free radicals are suspected as triggers of various degenerative diseases. Antioxidants are compounds that can counteract free radicals. This study aims to determine the antioxidant activity by DPPH method and analyze the active compounds contained in romaine lettuce extract (Lactuca sativa var Longifolia) and lactuca sativa var Crishpa lettuce extract (Lactuca sativa var Crishpa). Romaine lettuce and and lactuca sativa var Crishpa was done extraction with a maceration method using 70% as ethanol solvent. The concentration of extract used was 12.5; 25; 50; 100; 200 and 400 ppm and vitamin C concentrations as comparison was 0.5; 1; 1.5; 2; 2,5 and 3 ppm tested its antioxidant activity by DPPH method by spectrophotometry visible, until IC50 value was obtained. The identification of the active compound was performed by phytochemical screening and Thin Layer Chromatography (TLC). The results showed that romaine lettuce has IC50 value of 151,1515 ppm and lactuca sativa var Crishpa has IC50 value of 183,7560 ppm and vitamin C value was 1,7005 ppm. The chemical compounds contained in romaine ethanol extract and lactuca sativa var Crishpa lettuce extract are alkaloids, phenols and flavonoids.Keywords: Antioxidant, DPPH, IC50, TLC, Romaine, Lactuca sativa var Crishpa
Cover Cover
Jurnal Ilmu Farmasi dan Farmasi Klinik, Volume 16; https://doi.org/10.31942/jiffk.v16i01.2920

Abstract:
Jurnal Ilmu Farmasi & Farmasi Klinik Journal of Pharmaceutical Science & Clinical Pharmacy Pemimpin Umum/ Penanggung jawab Dekan Fakultas Farmasi Universitas Wahid Hasyim Pemimpin Redaksi Ketua Program Studi Farmasi Fakultas Farmasi Universitas Wahid Hasyim Redaktur Ahli Dr. Sumantri, M.S., Apt Prof. Dr. SuwijiyoPramono, Apt Prof. Dr. Mustofa, M.Kes, Apt Dr. Mimiek Murukmihadi, SU., Apt Dr. Mufrod, M.Sc., Apt Redaktur Pelaksana Elya Zulfa, S.Farm., M.Sc., Apt Staf Redaksi : Ririn Lispita Wulandari, S.Farm., M.Si.Med, Apt. Dewi Andini Kunti, S.Farm., M.Farm., Apt Devi Nisa Hidayati, M.Sc., Apt Danang Novianto, S.Farm., Apt Sekretaris Redaksi Anita Dwi Puspitasari, S.Si., M.Pd Distributor Imam Asrofi Alamat Redaksi/Tata Usaha Fakultas Farmasi Universitas Wahid Hasyim Jl. Menoreh Tengah X/22 Sampangan Semarang Telp. 024-8505680, 8505681 Fax. 024-8505680 E-mail :[email protected] Terbit 2 kali setahun sejak September 2004
, Mufrod Mufrod, Feyzar Habib Reynaldo, Ayuk Siti Fatimah, Yayang Rusyta Dewi
Jurnal Ilmu Farmasi dan Farmasi Klinik, Volume 16, pp 70-79; https://doi.org/10.31942/jiffk.v16i01.2932

Abstract:
Noni leaf (Morinda citrofolia L.) has antioxidant compounds that can inhibit and counteract free radicals. Decocta Noni leaf to make more practice preparation of lozenges. This study aims to evaluate the physical chemical characteristics and taste response of lozenges with variations of sweeteners to cover the bitter taste of Noni leaves. Decocta mengkudu leaf is obtained by boiling at 90C for 30 minutes. Suction tablets made 9 formulas based on variations of sweeterners sucrose-water sweetener, sorbitol-sucrose-sugarcane water, and aspartame-sucrose-sugarcane water. The suction tablet is made by molding mixture method. Evaluation of physical chemical characteristics including hardness and solubility were analyzed statistically using one-way ANOVA with 95% confidence level, followed by tukey test, weight uniformity, taste response and thin layer chromatography analyzed descriptively. The results of the study was showed that influenced the increase in hardness and dissolution time and the results of the requirements physical lozenges The results of the TLC test of lozenges and decocytes showed an RF value close to Quercetin. The taste response test results showed formula I with variations of sugarcane-sucrose water sweetener, formula III with variations in sorbitol-sucrose-sugarcane-water sweetener and sugarcane water aspartame-sucrose was the most preferred by respondents of 85% - 95%.Keywords: leaf of morinda citrifolia l., lozenges, sorbitol, aspartame, sucrose, sugarcane water
Pengantar Redaksi
Jurnal Ilmu Farmasi dan Farmasi Klinik, Volume 16; https://doi.org/10.31942/jiffk.v16i01.2921

Abstract:
Assalamualaikum Wr.Wb Alhamdulillah seiring dengan perjalanan Fakultas Farmasi Universitas Wahid Hasyim Semarang, Jurnal Ilmu Farmasi dan Farmasi Klinik (JIFFK) telah memasuki tahun ke-16 semenjak penerbitan perdana tahun 2004. Kami tetap berharap bahwa JIFFK dapat memberikan kontribusi bagi perkembangan ilmu farmasi dan farmasi klinik. Kami berharap bahwa JIFFK ini dapat digunakan sebagai wadah bagi para peneliti, akademisi dan pemerhati ilmu farmasi dan farmasi klinik untuk mempublikasikan hasil penelitian atau pemikirannya. Demi menjaga eksistensi dan sustainabilitas JIFFK kami senantiasa memohon sumbangan tulisan atau artikel dari para peneliti. Kami selalu berusaha untuk dapat meningkatkan kualitas dari setiap penerbitan JIFFK ini, karena kami memiliki cita-cita supaya JIFFK dapat terakreditasi dari dikti. Akhir kata kami sampaikan terima kasih yang sebesar-besarnya kepada semua pihak yang telah membantu terlaksananya penerbitan ini. Kritik dan saran kami nantikan dari pembaca sekalian demi perbaikan dan kemajuan JIFFK. Wassalamu’alaikum Wr. Wb Semarang, Juni 2019 Hormat Kami Redaksi
, Hairunisa Hairunisa, Emy Nadya Natasha
Jurnal Ilmu Farmasi dan Farmasi Klinik, Volume 16, pp 59-64; https://doi.org/10.31942/jiffk.v16i01.2930

Abstract:
Prevention and treatment with synthetic antidepressants has many side effects that affect the central nervous system and usage must be under the supervision of a doctor. Whereas prevention and traditional medicine relatively do not cause side effects, are inexpensive, and easy to obtain. One example of traditional medicine from natural ingredients, which can provide an antidepressant effect is ginger rhizome. This research aims to determine whether ginger rhizome have antidepressant effects on male white mice. Antidepressant effect testing was carried out on male white mice (Mus musculus) using the forced swim test method. The part of the plant used is the rhizome of the ginger plant. Curcuma rhizome is made with juice and given orally with a concentration of 20%, 40%, and 60%. The negative control used is Na CMC 0.5%, while the positive control used, namely amitriptilyn. The parameters observed were the duration of immobility time, swimming time and climibing time (in seconds) which were calculated from minutes 3-6 for 6 minutes, and statistical tests were carried out with a confidence level of 95%. The results showed that at a concentration of 40% the curcuma rhizome juice had a significant value (p> 0.05) which means that there was no significant difference in antidepressant effect (%) from the juice of temulawak 56.31% and amitriptylin 78.78%Keywords: ginger rhizome, antidepressants, the forced swim test
Wida Ningsih, Diana Agustin, Putri Sefrianti
Jurnal Ilmu Farmasi dan Farmasi Klinik, Volume 16, pp 51-58; https://doi.org/10.31942/jiffk.v16i01.2929

Abstract:
Candida albicans is a normal flora in the female genitalia which can cause vaginal discharge. White galangal rhizome contains essential oils of eugenol which have activities that inhibit the growth of Candida albicans. This study formulated the white galangal rhizome essential oil in the form of feminime hygiene to make it easier and more comfortable to use and to determine the antiseptic feminime hygiene activity of the white galangal rhizome oil of Candida albicans. The essential oil of white galangal rhizome is formulated in three variations of concentration namely 10%, 15% and 20%. Feminime hygiene of essential white galangal rhizome oil was evaluated such as organoleptic, homogeneity, specific gravity, foam power test, viscosity, pH and stability. Antiseptic activity testing was tested with SDA (Sabouraud Dextrose Agar) media and using agar diffusion method. The results of the feminime hygiene evaluation formulated showed results similar to the results of comparative evaluations (BN). The parameters of antiseptic activity are indicated by the formation of inhibitory zone diameters where F0 (negative control), F1 (10%), F2 (15%), and F3 (20%) respectively have an average diameter value of 11 mm, 14.65 mm 17.58 mm and 25.41 mm. The classification category of the response to microbial growth according to CLSI, F0 and F1 includes the weak group, the F2 is the moderate group and the F3 is the strong group. Based on the results of one-way ANOVA statistical analysis there were significant differences in liquid soap preparations F0, F1, F2 with F3 at (P
, Elin Yulinah Sukandar, Asep Gana Suganda, Muhamad Insanu
Jurnal Ilmu Farmasi dan Farmasi Klinik, Volume 16, pp 43-50; https://doi.org/10.31942/jiffk.v16i01.2928

Abstract:
Acetylcholine is a conducting compound of nerve excitatory (neurotransmitter), while acetylcholinesterase is an enzyme that can hydrolyze the acetylcholine into choline and acetic acid. This reaction is needed so that the nerves can return to take a rest after the activation process, but it can cause damage to the cells in the brain. The most common case is dementia characterized by memory loss. The prevalence of this disease is lower in China and some other Asian countries compared to the United States. It supposed because food consumption commonly by Asians contain vegetables. Extracts derived from vegetables potentially inhibit the activity of acetylcholinesterase (AChE) enzyme which related to chemical contents of the plant. This research aims to investigate the inhibitory activity of acetylcholinesterase enzyme from 4 types of vegetables namely soybean sprouts (bean sprout of Glycine max (L.) Merr.), green bean sprouts (bean sprout of Vigna radiata), carrot (Daucus carota L.), and winged beans (Psophocarpus tetragonolobus (L.) DC.) by in vitro with the Ellman method. Total phenolic and flavonoids contents from fourth types of extracts were also determined. The winged beans extract had the smallest total phenolic and flavonoid contents, but the inhibitory activity against AChE was the biggest. The results showed that IC50 extract of winged beans was 893.86 μg/ml, IC50 carrot extract higher than 1500 μg/ml while the other extracts had no activity. The winged beans extract potential to be further developed as an inhibitor AChE.Keywords : inhibitor of acetylcholinesterase, IC50, vegetables
, Fitri Sri Rizki
Jurnal Ilmu Farmasi dan Farmasi Klinik, Volume 16, pp 8-14; https://doi.org/10.31942/jiffk.v16i01.2923

Abstract:
Dayak onion contains alkaloid compounds, flavonoids, saponins, tannins, glycosides, and triterpenoids which have anti-acne effects. This study aims to make cream formulas from Dayak onion ethanol extract and evaluate the physical quality characteristics of cream. The cream formulation from dayak onion extract was made with extract concentration of 100 mg/ml with stearic acid and triethanolamine as emulgator. Stearic acid and triethanolamine concentrations used were FI (6%: 2%), FII (12%: 3%), FIII ( 18%: 3%). The creams were evaluated for its physical quality characteristics, namely organoleptic, homogeneity, pH, dispersion, cream type and viscosity. From the evaluation of physical quality characteristics, it can be concluded that Formula III is the best formula that meets good cream quality requirements. The Dayak onion ethanol extract cream is an O/W type cream resulting in semi-solid, brown, organoleptic and dayak onion odor. In the homogeneity test there is no clumping on the cream preparation so that the preparation is homogeneous. The pH value is 6, so the cream is safe for the face. The spreadability of FIII is 7.52 cm, meets the requirements. The viscosity of F III is 32000 cPs, meets the requirements of a good cream preparation viscosity.Keywords: Formulation, Cream, Dayak Onion Extract (Eleutherine palmifolia (L.) Merr).
Ariyanti Ariyanti, Eni Masruriati, Arin Widya Nuari, M. Himawan Yoga Syahputra
Jurnal Ilmu Farmasi dan Farmasi Klinik, Volume 16, pp 65-69; https://doi.org/10.31942/jiffk.v16i01.2931

Abstract:
Chitosan is the result of the deacetylation process of chitin by removing acetyl groups to obtain polymer compounds and glucosamine. Utilization of chitosan derived from waste of Amusium pleuronectes and Polymesoda erosa has not been maximize. This study aims to determine the highest chitosan yield in Amusium pleuronectes and Polymesoda erosa. The method used in this study was a deacetylation isolation method with five replications. The yield of the yield content was analyzed by univariate and bivariate with spps 19.0 using a ttest. Based on the results of the research on the sample of Amusium pleuronectes and Polymesoda erosa, the highest yield of chitosan at 75% b/v concentration of NaOH was 6,972% b/v for Amusium pleuronectes and 5.972% b/v for Polymesoda erosa. The results showed that NaOH concentrations of 15v, 25, 50, and 75% b/v could affect the chitin change to chitosan against Amusium pleuronectes and Polymesoda erosa.Keywords: Amusium pleuronectes, Polymesoda erosa, deacetylation, chitin, chitosan
, Desi Rakhmawati, Layyinatul Fuadah, Nola Carina Rahayu
Jurnal Ilmu Farmasi dan Farmasi Klinik, Volume 16, pp 28-35; https://doi.org/10.31942/jiffk.v16i01.2926

Abstract:
Parijoto is one of a rare plant species in Indonesia, and its leaves have traditionally been utilized to treat diarrhea in the area of Kudus Regency, Indonesia. Parijoto leaves contain active compounds of tannin and flavonoid which have antidiarrheal properties. This investigation intends to demonstrate the antidiarrheal effect of parijoto leaf ethanol extract (EEDP) on male Balb/C mice castor oil-induced diarrheal and reveal its antidiarrheal mechanism through antimotility and antisecretory testing. EEDP made by maceration method. The antidiarrheal effects of three series level EEDP (500; 1,000 and 2,000) mg / Kg BB tested on diarrhea mice induced by castor oil. Concurrently, the antimotility and antisecretory effects of EEDP investigated with the intestinal transit method and castor oil-induced enteropooling. The data in this study were the onset of diarrhea, the weight of liquid-formless stools (for 8 hours), the ratio of digestion tracts passed by norit markers, and the volume of intestinal contents. These data were analyzed statistically at the 95% confidence level. The examination presumed that EEDP was able to respite the onset of diarrhea and diminish the formation of liquid-formless feces in male Balb/C mice induced by castor oil. The antidiarrheal mechanism of EEDP also exhibited in this study through its effects as antimotility and antisecretory.Keywords: Parijoto leaf ethanol extract, antidiarrheal, antimotility, antisecretory
Eva Monica, Rollando Rollando
Jurnal Ilmu Farmasi dan Farmasi Klinik, Volume 16, pp 80-85; https://doi.org/10.31942/jiffk.v16i01.2933

Abstract:
Lycopene is one of the phytochemical compounds of the carotenoid group, the main producer of red pigments found in watermelons. Watermelon is a round-shaped vines containing vitamin C and vitamin A and has high antioxidant levels. This study aims to identify lycopene compounds in watermelons. Extraction of watermelon flesh by maceration method. Identification of lycopene compounds with UV-Visibel spectrophotometry instrument followed by identification with the TLC method and fractionation of extracts using preparative TLC with chloroform: ethanol (1: 1) solvents, and identification of fractionation results with Fourier Transform Infrared Spectroscopy (FT-IR). The results of the identification of watermelon fruit extract using the TLC method obtained three spots and the results of UV-Vis spectrophotometry showed three peaks namely between 440-520 nm. The identification of fractionation of watermelon extract using FT-IR obtained a constituent group of lycopene structures, but did not show the R-CH = CH-R group that is owned by lycopene, whereas the results of the test with UV-Vis spectrophotometry appearing at 206 and 245 which indicate the presence of other compounds. From the results of the study it can be concluded that the testing of known extracts of watermelon fruit contains lycopene compounds, but the testing of lycopene identification on the results of fractionation of watermelon fruit extracts was not found with certainty the existence of lycopene because the FT-IR results were only shown and contained on the results UV-Vis spectrophotometry was found to be the wavelength of other compounds.keywords: Watermelon, Lycopene, UV-Vis Spectrophotometry, IR Spectrophotometry
, Yance Anas, Idress Muhammed Hama
Jurnal Ilmu Farmasi dan Farmasi Klinik, Volume 16, pp 36-42; https://doi.org/10.31942/jiffk.v16i01.2927

Abstract:
Neurodegenerative is often associated with aging. The aging process will affect the decrease in nerve cells, especially brain nerve cells. Ethyl acetate fraction of kemukus fruit ethanol extract (FEAEE) of kemukus fruit has been investigated as a memory enhancer with the Morris water maze (MWM) method. One of the shortcomings of the Morris water maze method is that it causes stress in test animals, thus affecting their memory. This study aims to determine the memory enhancing activity of FEAEE of kemukus fruit with the radial arm maze method This research is an experimental study with pre and posttest matched control group design using 25 male mice, Balb/c strains divided into 5 groups. Mice group 1 as a negative control group were given a 1% CMC Na solution of 17.5 mg/mL. Group mice 2 - 5 were given FEAEE of kemukus fruit with doses of 63, 126, 252, and 504 mg/kgBB, respectively. Test material is given orally for 21 days. Observations were made on the frequency of mice passing the platform correctly and incorrectly and calculating memory scores using the radial arm maze (RAM) method. Differences in memory scores were analyzed by the Mann Whitney test. The results showed that FEAEE steamed fruit has memory enhancing activity. Memory activity was indicated at doses of 63 and 252 mg / kg.Keywords: steamed fruit (Piper cubeba, L. f), ethyl acetate fraction, memory score, radial arm maze
Rollando Rollando, Muhammad Hilmi Afthoni
Jurnal Ilmu Farmasi dan Farmasi Klinik, Volume 16, pp 15-20; https://doi.org/10.31942/jiffk.v16i01.2924

Abstract:
Pumpkin (Cucurbita moschata Duch ex Poiret), a fruit that contains several compounds, has activities to protect the human body from free radicals. Provitamin A is recognized as an antioxidant compound. Antioxidants can protect the body’s damage caused by free radicals. The purpose of this study was to isolate beta carotene compounds and test the purity of beta carotene isolates obtained using DR-UV and infrared spectrophotometry. Pumpkin is extracted using acetone: petroleum ether with a ratio (1: 1). Identification of beta carotene from extracts was carried out using TLC with the mobile phase of ethanol: acetone: n-hexane with a ratio (2: 1: 1) and scan spectrum using a UV-Vis spectrophotometer. Beta carotene was identified as the result of TLC elution on UV 254 and 366 nm which showed 2 spots. Detection of beta carotene spectra was carried out in the range of 350 to 550 nm and obtained beta carotene peaks at wavelength x nm. The extract purification process was carried out using Preparative TLC with the mobile phase of ethanol: acetone: n-hexane with a ratio (2: 1: 1) and obtained isolates cleaned first using chloroform: methanol ratio of 1: 1. The isolates were dried and tested using DR-UV and infrared spectrophotometry. Isolates from Cucurbita moschataDuch ex Poiret extract) contain beta carotene, zeaxanthin.Keywords: pumpkin; beta carotene; isolation
, Risha Fillah Fithria, Fitria Dwi Kurniawati, Ulfa Risalatul Mukaromah
Jurnal Ilmu Farmasi dan Farmasi Klinik, Volume 16, pp 1-7; https://doi.org/10.31942/jiffk.v16i01.2922

Abstract:
Diltiazem HCL is an antihypertensive that low oral bioavailability of 40%, so developed to transdermal preparations. A matrix type of transdermal patch of diltiazem HCl was prepared using polyvinyl alcohol and ethyl cellulose with PEG 400 as penetration enhancer. In vitro-in vivo evaluation were conducted to asses drug permeation through the skin and determine the effectiveness of transdermal film as an antihypertensive drug. Transdermal patches of diltiazem HCl were evaluated for physicochemical characteristics weight variation, thickness, folding endurance, moisture uptake, and drug content. In vitro permeation study was conducted using commercial semi permeable membrane in Franz diffusion cell. In vivo activity study was evaluated on male rat Wistar that induced NaCl with CODA non-invasive blood pressure method. Transdermal patches of diltiazem HCl were found no significant differences in terms of physicochemical characteristics. The in vitro skin permeation profiles showed increased flux values with the increase of PEG 400 as a penetration enhancer. The in vivo evaluation showed a reduction in systolic and diastolic blood pressure within one hour after the drug administration. Diltiazem HCl was able penetration into skin, absorbed in blood circulation and effective as antihypertensive via transdermal route.Keywords : antihypertension, diltiazem HCl, PEG 400, transdermal patch
, Ririn Lispita Wulandari, Devi Nisa Hidayati, Lilis Rejeki
Jurnal Ilmu Farmasi dan Farmasi Klinik, Volume 15, pp 62-70; https://doi.org/10.31942/jiffk.v15i2.2568

Abstract:
Peanut shell (PS) infusion has been shown to be antithrombocytopenia, but there has been no research on safety standards. This study aims to identify the symptoms of toxic effects, the potency of toxicity and histopathology of liver male Balb/C mice after a single dose of PS infusion. This research uses randomized matched posttest only control group design. Twenty five mice were divided into 5 orally dosage groups, ie, PS infusion with a dose of 0,026; 0.052; 0.104; 0.208 g/20gBW; and negative control of CMC Na 0.5%. The observation period is for 14 days. The results showed that single dose of PS infusion had a pseudo LD50 value ie > 0.208g/20gBW which was practically non toxic. Symptoms to watch out for the BW infusion were passive behavior, bradycnea, hair color change, hair loss, and weight loss at doses of 3 and 4. It is unclear whether liver damage ie inflammation, necrosis, and albuminous degeneration caused by PS infusion or other causes.keywords: acute toxicity, infusion, peanut shell
, Ryan Radix Rahardian
Jurnal Ilmu Farmasi dan Farmasi Klinik, Volume 15, pp 36-40; https://doi.org/10.31942/jiffk.v15i2.2564

Abstract:
Dayak Onion (Eleutherine palmifolia (L.) Merr) is known to have several benefits including treating cancer, hypertension, lowering cholesterol. This study aims to determine the non-specific parameters of ethanol extract from Dayak onion bulbs which include drying shrinkage parameters, moisture content, ash content, acid insoluble ash content. Extraction was carried out percolation with 96% ethanol and yielded a yield of 12.44%. Dayak onion tuber extract was thick with a distinctive smell of onion and reddish brown color. The contents of the active compounds include flavonoids, saponins, tannins, alkaloids and quinones. The results showed a shrinkage value of 9.73 ± 0.10%, moisture content 9.42 ± 0.36% ash content 4.83 ± 0.27% and acid insoluble ash content 0.45 ± 0.49Keywords: Dayak Onion, 96% ethanol extract, non specific parameters
, Anastasia Setyopuspito P, Yustisia Dian Advistasari
Jurnal Ilmu Farmasi dan Farmasi Klinik, Volume 15, pp 77-82; https://doi.org/10.31942/jiffk.v15i2.2570

Abstract:
The purpose of this study is identification and analysis of the macronutrient glucomannan from porang tuber (Amorphophallus onchopyllus). The stages done in this research are extraction, identification, and macronutrient analysis of glucomannan of the porang tuber. Prior to extraction, the oxalic acid was removed from porang tuber using mixture of 2% lime juice and 5% lime, then the glucomannans was extracted using ultrasonic method. The glucomannan then was identified using Fourier transform infra red spectrometer (FTIR) instrument and macronutrient analyzer such as Soxhlet method for fats and fibers, Kjedahl method for protein, and Antrone method for carbohydrates. The results of identification using FTIR showed the presence of β-pyranose at wave numbers of 900-810 cm -1 . The carbonyl on on acetyl group was found at 1726 cm-1 . The area between 870-800 cm-1 showed the β-glycosidic and β-manosidic compounds. The C-O ether group was shown in the area of 1260-1200 cm -1 , while for C-O alcohol was shown in the area of 1050 cm-1 showed the C-O bond in alcohol. At 2925 cm-1 it showed C-H, while at 3000-3700 cm-1 O-H group. The levels of porang glucomannan macronutrients included fat at 0.50%, protein at 1.05%, fiber at 22.34%, and carbohydrates at 31.33%.Key word: Porang tuber, glucomannan, FTIR, macronutrient analysis.
Cover Cover
Jurnal Ilmu Farmasi dan Farmasi Klinik, Volume 15; https://doi.org/10.31942/jiffk.v15i2.2573

Abstract:
Jurnal Ilmu Farmasi & Farmasi Klinik Journal of Pharmaceutical Science & Clinical PharmacyPemimpin Umum/ Penanggung jawab Dekan Fakultas Farmasi Universitas Wahid Hasyim Pemimpin Redaksi Ketua Program Studi Farmasi Fakultas Farmasi Universitas Wahid Hasyim Redaktur Ahli Dr. Sumantri, M.S., Apt Prof. Dr. SuwijiyoPramono, Apt Prof. Dr. Mustofa, M.Kes, Apt Dr. Mimiek Murukmihadi, SU., Apt Redaktur Pelaksana Elya Zulfa, S.Farm., M.Sc., Apt Staf Redaksi : Ririn Lispita Wulandari, S.Farm., M.Si.Med, Apt. Dewi Andini Kunti, S.Farm., M.Farm. Devi Nisa Hidayati, M.Sc., Apt Danang Novianto, S.Farm. Sekretaris Redaksi Anita Dwi Puspitasari, S.Si., M.Pd Distributor Imam Asrofi Alamat Redaksi/Tata Usaha Fakultas Farmasi Universitas Wahid Hasyim Jl. Menoreh Tengah X/22 Sampangan Semarang Telp. 024-8505680, 8505681 Fax. 024-8505680 E-mail :[email protected] Terbit 2 kali setahun sejak September 2004
Wida Ningsih
Jurnal Ilmu Farmasi dan Farmasi Klinik, Volume 15, pp 71-76; https://doi.org/10.31942/jiffk.v15i2.2569

Abstract:
The tannins contained in areca nut extract can inhibit the growth of Streptococcus mutans bacteria. To facilitate the use of betel seed extract as an antibacterial, it was formulated into an edible film with a concentration of 2.5%, 3% and 3.5%. Making edible films using solvent casting method and testing antibacterial activity using blood agar diffusion method. The edible film of areca nut extract made an evaluation included organoleptic, thickness, brittleness, water content, pH, and swelling test. The evaluation results of betel nut edible fim extract showed almost the same characteristics as the edible fim that had been circulating in the market which was used as a comparison. The presence of antibacterial activity from edible pinang seed extract is marked by the formation of clear zones. The test results of antibacterial edible activity of areca nut extract films 2.5%, 3% and 3.5% showed the average diameter of clear zone was 14.96 mm, 15.49 mm and 17.05 mm which were included in the strong category.Keywords: Areca catechu Linn, antibacterial, edible film, tannin, streptococcus
Ika Puspitaningrum, Yuvianti Dwi Franyoto, Siti Munisih
Jurnal Ilmu Farmasi dan Farmasi Klinik, Volume 15, pp 48-53; https://doi.org/10.31942/jiffk.v15i2.2566

Abstract:
Ethyl acetate fraction of Som Java leaves (Talinum paniculatum (Jacq.) Gaertn) has been shown to boost innate immunity in the body (non-specific immunomodulatory activity). This study aims to determine the immunomodulatory activity of the specific response of the ethyl acetate fraction of Som Java leaves (Talinum paniculatum (Jacq.) Gaertn). Test specific immune response by using delayed type hypersensitivity test and total antibody titers test. Analysis of data obtained using SPSS version 16.0. Delayed type hypersensitivity test results showed that the ethyl acetate fraction Som Java leaves 50, 100 and 150 mg/kgbw proven to increase cellular immune response and activities comparable to the positive control. Total antibody titer test results showed that the fraction of ethyl acetate Som Java leaves three doses shown to increase the value of primary and secondary antibody titers. Based on the test results specific response can be concluded that the ethyl acetate fraction Som Java leaves have specific immunomodulatory activity.Keywords: Talinum paniculatum (Jacq.) Gaertn, immunomodulatory, delayed type hypersensitivity, total antibody titer test
, Mufrod Mufrod
Jurnal Ilmu Farmasi dan Farmasi Klinik, Volume 15, pp 41-47; https://doi.org/10.31942/jiffk.v15i2.2565

Abstract:
In previous research, ethanolic extract of pineapple peel (EEPP) has activity as a sunscreen because of the content of flavonoids. EEPP can be formulated in the form of creams and lotions to facilitate use on the skin. This study aims to evaluate the physical chemistry characteristics of EEPP creams and lotions. Creams and lotions were made in 3 formulas based on variations in FI extract concentrations (15.0%), FII (17.5%), FIII (20.0%), base controls and positive controls (preparations on the market). The cream obtained was evaluated for physical chemical characteristics including organoleptic, homogeneity, adhesion and dispersion, viscosity, pH and SPF values which were analyzed descriptively. cream with varying concentrations of green, the distinctive smell of pineapple, homogeneous and in accordance with the pH of the skin. Increasing the concentration of EEPP in the preparation has an effect on increasing viscosity, adhesion but decreasing the dispersion. Whereas the lotion shows greenish color, aromatic odor and semisolid texture and is easily applied. The increase in EEPP in lotion affects the increase in pH, adhesion, but decreasing the dispersion.Keywords: Creams, lotions, sunscreen, pineapple fruit skin
Jurnal Ilmu Farmasi dan Farmasi Klinik, Volume 15, pp 13-17; https://doi.org/10.31942/jiffk.v15i2.2560

Abstract:
Breadfruit leaves contain flavonoid compounds that can inhibit the growth of Staphylococcus aureus bacteria. Breadfruit leaf extract is practical and effective formulated in ointment preparations. The base combination of PEG 400 and PEG 4000 decreases the melting point of PEG 4000, so that it is compatible and can increase the penetration of drugs in the skin. The objective of this study to determine the breadfruit leaf extract ointment with a combination of PEG 400 and PEG 4000 bases as well as antibacterial activity against Staphylococcus aureus bacteria. Breadfruit leaf extract (BLE) was obtained by maceration with 70% ethanol. Salve preparations were made into III formulas with variations in base concentrations of PEG 400 and PEG 4000, namely (F1) 75%: 25%, (F2) 50%: 50%, (F3) 25%: 75%, using the fusion method. Antibacterial activity test used agar well diffusion method. Kruskal Wallis test and Mann Whitney test used for analyzed data from antibacterial activity test. The ointment of Breadfruit leaves extract showed the color of brown ointment, semi-solid form, distinctive aroma of breadfruit leave. All of three ointment formulas have antibacterial activity indicated by the formation of inhibitory zones around the well. All of three ointment formulas have significant differences which means the combination of PEG 400 and PEG 4000 can affect antibacterial activity of BLE ointment. The higher of the concentration PEG 4000 compared PEG 400 caused inhibiton zone become smaller that means the potency of antibacterial decreased. The formula has the greatest antibacterial activity in the FI is 8,02mm.Keywords: breadfruit leaves, ointment, PEG 400 and PEG 4000, antibacterial
, Asih Puji Lestari
Jurnal Ilmu Farmasi dan Farmasi Klinik, Volume 15, pp 1-7; https://doi.org/10.31942/jiffk.v15i2.2558

Abstract:
Chronic diabetes mellitus is a disease of increased blood glucose levels in a long time so that it can affect sexual function such as damage spermatogenesis and aphrodisiac function. Parijoto has flavonoid content. This study aimed to determine the effect of ethanolic extract of parijoto (Medinilla speciosa Blume) fruit in blood glucose level and the sexual function in alloxan-induced diabetic male rats. The design of the study was post test only control group design, 25 male wistar rats aged 2 months with BB 100-200 gram divided into 5 groups. Group 1 (normal control), group 2 (negative control) induced alloxan 100mg / kgBB, groups 3, 4, and 5 were alloxan induced and administered EEBP at doses of 100 mg / kgBW, 250 mg / kgBW, and 500 mg / kgBW. Alloxan-induced rats were left for 4 weeks to achieve chronic DM. Data analysis of blood glucose level and spermatozoa quality using one way anova followed by LSD post hoc. While aphrodisiac of introducing and climbing using one way anova continued by LSD and coitus using kruskal wallis. The results showed that there were significant differences between negative control with normal group, III, IV, and V. The effect of ethanolic extract of parijoto fruit on blood glucose level and sexual function in alloxan-induced diabetic male rats showed no difference between treatment group of 100 mg / kgBW with negative group, and there were significant differences between treatment group of 250 mg / kgBW and 500 mg / kgBW with negative group. Ethanolic extract of parijoto fruit at dose 250 mg / kgBB and 500 mg / kgBB decrease blood glucose level, improve and increase sexual function in alloxan-induced diabetic male rats.
Jurnal Ilmu Farmasi dan Farmasi Klinik, Volume 15, pp 8-12; https://doi.org/10.31942/jiffk.v15i2.2559

Abstract:
The purpose of this research is to find out the profile of secondary metabolite contained in the extract of seeds (Crescentia cujete Linn.) And cytotoxic test against shrimp larvae Artemia salina Leach by BSLT method. Phytochemical tests showed that the extract be expected contained the terpenoid, alkaloid, phenolic, secondary metabolite compounds. The results of qualitative analysis with positive TLC contains phenolics. The result of identification with Spectrophotometer UV-visfor determination of α max from berenuk seeds extract consisted of 3 peaks with α max 326 nm, 258 nm, 222 nm be expected terpenoid compound, alkaloid, and phenolic. The results of toxicity test using shrimp larvae (Artemia salina leach) were divided into 4 groups: 1 control group and 3 groups of concentration series. The concentration of test solution used was 1,000, 100 and 10 μg / ml. The shrimp larvae mortality was observed after 24 hours of treatment. Based on the analysis with probit method, LC50 value of seed extract berenuk to shrimp larvae Artemia salina Leach is equal to 82,30 μg/ml. This shows that the extract of berenuk berries is toxic to shrimp larvae Artemia salina Leach, presence to terpenoid content, alkaloids and phenolics in the extract of seeds berenuk.Keywords : Secondary metabolite; Cytotoxic; BSLT.
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