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Results in Journal Journal of Pharmaceutical And Sciences: 32

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Nilsya Febrika Zebua , Sudewi Sudewi, Masrina Prihatini
Journal of Pharmaceutical And Sciences, Volume 2, pp 1-9; doi:10.36490/journal-jps.com.v2i1.10

Abstract:
Collagen is one of the proteins that make up the body or the organic structure that builds bones, teeth, joints, muscles, and skin. Collagen is very often used by the community because it is to maintain healthy skin and maintain skin elasticity. This study aims to determine collagen from bovine bones can be formulated into transparent soap preparations. Bovine bone collagen (Bos sp.) was extracted by immersion using 1N NaOH. The production of transparent soap formulas in several concentrations is 0.5%, 1%, 2.5%, and 5% collagen. The bovine bone collagen yield was obtained 27.5%. Collagen in a variety of concentrations produces different colors and the ability to moisturize the skin. Bovine bone collagen (Bos sp.) was formulated in transparent soap preparations from bovine bone collagen (Bos sp.) with a concentration of 0.5% including the category "moist" and transparent soap preparation from bovine bone collagen (Bos sp.) 1% , 2.5%, and 5% including the category of "very humid" and the results of testing on volunteers showed that transparent soap from collagen in bovine bone (Bos sp.) did not cause irritation.
Muhammad Taufik , Desi Ardilla, Mariany Razali, Maya Handayana Sinaga
Journal of Pharmaceutical And Sciences, Volume 1, pp 7-15; doi:10.36490/journal-jps.com.v1i1.2

Abstract:
Indonesia is the country with the largest level of Muslim population in the world. Guarantees for the safety and protection of consumers in the food sector must be considered. One of the parameters used in product halal is total microbial analysis. The sample used was processed tuna which is adulterated with lard (1: 1). The research method uses Factorial Completely Randomized Design method which consists of two factors, Factor I: Solvent Concentration (K) consists of 4 levels, namely: K1 = 20%, K2 = 30%, K3 = 40%, K4 = 50%, Factors II: Maseration Time (W) consists of 4 levels : W1 = 06 Hours, W2 = 12 Hours, W3 = 18 Hours, and W4 = 24 Hours. The results showed that the n-hexane concentration had a very significant effect (p
Ridho Asra , Festires Kurnia Harefa, Zulharmita Zulharmita, Nessa Nessa
Journal of Pharmaceutical And Sciences, Volume 1, pp 32-38; doi:10.36490/journal-jps.com.v1i1.5

Abstract:
Telah dilakukan penetapan kadar logam kalsium dan besi pada sampel daun kelor yang diperoleh dari daerah Purus, Kecamatan Padang Barat. Dalam penelitian ini proses destruksi yang digunakan adalah destruksi basah. Hasil dari destruksi ini selanjutnya diukur dengan spektrofotometer serapan atom menggunakan lampu katoda berongga Ca dan Fe sebagai sumber cahaya. Berdasarkan hasil penelitian didapatkan garis regresi linier dari larutan standar kalsium dengan persamaan y = 0,03818 + 0,17036x, dengan r = 0,9997, sedangkan untuk larutan standar besi didapatkan y = 0,03831 + 0,064275x, dengan r = 0,9986. Nilai batas deteksi (BD) dan batas kuantitasi (BK) dari kalsium yaitu 0,0678 mg/kg dan 0,2261 mg/kg, sedangkan nilai batas deteksi (BD) dan batas kuantitasi (BK) dari besi yaitu 0,5790 mg/kg dan 1,9292 mg/kg. Dari persamaan garis regresi linier tersebut diperoleh kadar kalsium dalam daun kelor dengan tiga kali pengulangan yaitu 1277,986 mg/kg, 1269,178 mg/kg, 1229,063 mg/kg sehingga rata-rata kandungan kalsium dalam daun kelor yaitu 1258,742 mg/kg. Sedangkan, hasil dari penetapan kadar besi dalam daun kelor dengan tiga kali pengulangan yaitu 210,509 mg/kg, 198,985 mg/kg, 206,117 mg/kg sehingga rata-rata kandungan besi dalam daun kelor yaitu 205,204 mg/kg
Journal of Pharmaceutical And Sciences, Volume 2, pp 17-23; doi:10.36490/journal-jps.com.v2i1.12

Abstract:
Research on the influence of polysaccharides from the jackfruit rags (Artocarpus Heterophyllus Lamk) on the content of glucose syrups on hydrolyzing with HCl 30% has been done. A sample has got with simple random sampling. The cellulose was isolated from the seeds of rags. The cellulose was hydrolyzed by HCl 30% to produce glucose syrups. The content was analyzed by the Nelson-Somogyi method and calculated by regression analysis. The results of analysis show that the content of glucose syrups from the cellulose from the jackfruit rags were 2.47%. Keywords: cellulose, jackfruit rags, glucose syrups, Hydrolysis
Muhammad Gun Gunawan , Nolani Nurlita Bengi
Journal of Pharmaceutical And Sciences, Volume 2, pp 9-17; doi:10.36490/journal-jps.com.v2i2.21

Abstract:
Decreased sexual desire is one of the factors of disharmony in the marital relationship and quite disturbing in domestic life, Medicine is traditionally widely taken, one using plants containing aphrodisiac. Aphrodisiac a kind of aphrodisiac to increase sex drive.In general, the plant compound that has potential as aphrodisiac is citrulline. Melon (Cucumis melo L.) is a plant that contains citrulline, which is used in the coating of white / albedo (mesocarp).This study aims to determine the melon fruit mesocarp have afrodisiaka effect on the effective dose. This study is an experimental method is percolation extraction using 30 mice were divided into 5 groups. Group I (CMC 0.5%), group II (herbal pegs the earth), Group III, IV, and V respectively using albedo Ethanol Extract Melon (EEAM) doses of 9, 18 and 36 g / kg. Oral administration by introducing watching, climbing and coitus. Observations were made for 5 days in a row. Statistical testing using test methods Post-Hoc Duncan SPSS 24.0. Statistical analysis showed no significant differences between the test group with α> 0.05 and an effective dose of 18g / kg.
Boy Chandra, Rezza Puspita Sari, Sestry Misfadhila, Zikra Azizah, Ridho Asra
Journal of Pharmaceutical And Sciences, Volume 2, pp 1-8; doi:10.36490/journal-jps.com.v2i2.20

Abstract:
Penelitian tentang uji fitokimia dan aktivitas antioksidan ekstrak metanol daun kemangi (Ocimum tenuiflorum L.) telah dilakukan. Simplisia daun kemangi dimaserasi dengan metanol 98 % diperoleh ekstrak sebesar 45,5479 g dengan rendemen 22,77 %. Ekstrak metanol daun kemangi megandung senyawa alkaloid, flavanoid, fenol, tanin, saponin, dan steroid. Ekstrak diketahui memiliki aktivitas antioksidan dengan menurunnya absorban DPPH. Aktivitas antioksidan dari ekstrak metanol daun kemangi dilakukan menggunakan metode DPPH untuk penentuan IC50. Dari pengujian dapat diketahui bahwa ekstrak daun kemangi memiliki aktivitas antioksidan dengan nilai IC50 1370,92 ppm. Berdasarkan nilai IC50 menunjukkan bahwa ekstrak metanol daun kemangi memiliki aktivitas antioksidan yang sangat lemah
Siti Maimunah, Rita Marthalena Zega, Alfi Sapitri
Journal of Pharmaceutical And Sciences, Volume 2, pp 55-62; doi:10.36490/journal-jps.com.v2i2.29

Abstract:
The shampoo is a dosage material used as a hair cleanser and epicarp head, especially the problem of dandruff caused by fungus. Kaffir lime has the content of essential oils, flavonoids and tannins are efficacious as an antifungal. The purpose of this study was to test the shampoo of kaffir lime and to know its inhibitory power to growth of Microsporum gypseum fungus. The type of this research is experiment with using agar diffusion method. Samples studied were epicarp juice of lime and mesocarp of kaffir lime with concentration respectively 10%, 20%, 30%, 40%, 50%. Shampoo dosage evaluation tests include inhibitory test, organoleptic test, pH test, high foam test and wetting test. The results showed that the lime mesocarp juice had inhibitory at 10% (13,09 mm) concentration, 20% (14,9 mm) concentration, 30% (18,52 mm) concentration, 40% concentration (20,86 mm ) and a concentration of 50% (22.53 mm). While the results of epicarp water of lime juice have a weak inhibitory power with a concentration of 10% (5,66 mm), Concentration of 20% (7,09 mm), concentration of 30% (8,09 mm), concentration of 40% (10,19), and concentration of 50% (11,36). Effective concentration on the preparation of shampoo preparations is the concentration of 20% and 30% of the lime juice mesocarp juice. The results of the evaluation test of two anti-dandruff shampoo formulations meet the requirements of a good shampoo and have respective inhabitants of F1 (20%) has a resistance of 14,54 mm and F2 (30%) has a resistance of 19,12 mm. Both dosage preparations are anti-dandruff.
Alfi Sapitri, Intan Afrinasari
Journal of Pharmaceutical And Sciences, Volume 2, pp 18-23; doi:10.36490/journal-jps.com.v2i2.23

Abstract:
Escherichia coli ditemukan di usus manusia dan hewan. Bakteri ini mudah menyebar dengan mencemari air dan makanan. itu bisa terjadi pada cincau (Mesona palustris) yang memiliki karbohidrat, serat dan nutrisi yang tinggi. Sebagian orang menggunakan campuran minuman cincau dan juga obat tradisional. Penelitian ini bertujuan untuk mengidentifikasi kontaminasi bakteri E. coli cincau yang dijual di Pasar Baru Stabat. Sampel dalam penelitian ini adalah cincau yang berasal dari 5 pedagang. Penelitian ini merupakan penelitian deskriptif. Metode penelitian adalah MPN (Most Probable Number) untuk menghitung bakteri coliform, diikuti dengan pemeriksaan media Lactosa Broth, Brilliant Green Lactose Broth media, media Eosin Metilyene Blue Agar, pewarnaan gram dan tes Biokimia. Hasil penelitian ini menunjukkan lima sampel yang diuji, ada satu sampel positif yang terkontaminasi dengan bakteri E. Coli dan 4 sampel negatif yang terkontaminasi E. coli. Sehingga empat sampel cocok untuk dikonsumsi dan satu sampel tidak sesuai untuk konsumsi.
Yenni Sri Wahyuni, Erjon Erjon, Reza Aftarida
Journal of Pharmaceutical And Sciences, Volume 2, pp 36-42; doi:10.36490/journal-jps.com.v2i2.27

Abstract:
Telah dilakukan penelitian tentang pengaruh suhu penyimpanan terhadap stabilitas klindamisin fosfat dalam sediaan emulgel. Penelitian ini bertujuan untuk mengetahui laju penguraian klindamisin fosfat dikarenakan variasi suhu penyimpanan dalam sediaan emulgel Emulgel klindamisin fosfat dilakukan penyimpanan pada suhu 30˚C, 50˚C, dan 70˚C. Pengukuran kadar dilakukan pada tiap interval waktu pada jam ke-0; 1; 2; 3; 4, dan jam ke-5. Penetapan kadar emulgel klindamisin fosfat menggunakan spektrofotometri UV-Vis kemudian hasil perolehan data dianalisa secara statistik menggunakan uji t berpasangan. Dari hasil penelitian didapatkan adanya penurunan kadar emulgel klindamisin fosfat pada sediaan dengan suhu penyimpanan 30˚C sebesar 99,0874%, suhu penyimpanan 50˚C sebesar 96,9314%, dan suhu penyimpanan 70˚C sebesar 96,0114% sehingga dapat dikatakan bahwa klindamisin fosfat dalam sediaan emulgel stabil secara kimia selama 5 jam pada suhu penyimpanan 30˚C, 50˚C, dan 70˚C dan kinetika laju penguraian klindamisin fosfat dalam sediaan emulgel mengikuti orde-2. Berdasarkan hasil pengolahan data secara statistik dapat dinyatakan bahwa suhu penyimpanan 30˚C, 50˚C, dan 70˚C menunjukkan data ada perbedaan signifikan (< 0.005)
Kasta Gurning , Dameria Siahaan, Iksen Iksen
Journal of Pharmaceutical And Sciences, Volume 2, pp 49-54; doi:10.36490/journal-jps.com.v2i2.28

Abstract:
Jackfruit leaves (Artocarpus heterophyllus Lamk.) have health benefits as an antimicrobial. The leaves contain flavonoids, tannins, saponins which act as antimicrobials. The purpose of this study was to study the potential antibacterial activity of ethanol extract of jackfruit leaves (Artocarpus heterophyllus Lamk.) On the bacteria Staphylococcus aureus, Escherichia coli, Staphylococcus epidermidis, and Salmonella typhi. This research conducted with an experimental method that included the collection and processing of samples, the examination of the simplicia characterization and phytochemical screening. The concentration of jackfruit leaf ethanol extract. Used was at a concentration of 500 mg mL, 400 mg/mL, 300 mg/mL, 200 mg/mL, 100 mg/mL, 100 mg/mL, 50 mg/mL , 25 mg/mL, 10 mg/mL 30 mg/ml chloramphenicol and blanks. Using the disk diffusion method to measure the clear zone against the bacteria Staphylococcus aureus, Escherichia coli, Staphylococcus epidermidis, and Salmonella typhi. Antimicrobial inhibition of ethanol extract of jackfruit leaves against Staphylococcus aureus bacteria at a concentration of 500 mg/mL has a strong antibacterial inhibition with a diameter of 10.8 mm. The bacteria Escherichia coli, Staphylococcus epidermidis, and Salmonella typhi at a concentration of 500 mg/mL have inhibitory power, 9.2 mm, 9.6 mm, and 8.8 mm in the medium category. Positive control chloramphenicol has powerful antibacterial inhibition with an inhibition zone diameter of 28.6 mm.
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