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Results in Journal Circulation Reports: 221

(searched for: journal_id:(4120860))
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Madoka Ihara, Yuhei Nojima, Nobuyuki Koh, Hidenori Adachi, Tetsuya Kurimoto, Keita Okayama, Yasushi Sakata, Shinsuke Nanto
Published: 10 September 2020
Circulation Reports; doi:10.1253/circrep.cr-20-0054

Abstract:
Japan's largest platform for academic e-journals: J-STAGE is a full text database for reviewed academic papers published by Japanese societies
Yuichi Tamura, Rika Takeyasu, Asuka Furukawa, Hiromi Takada, Mineki Takechi, Hirohisa Taniguchi, Akio Kawamura
Published: 10 September 2020
Circulation Reports, Volume 2, pp 526-530; doi:10.1253/circrep.cr-20-0088

Abstract:
Background:COVID-19 is fatal to patients with pulmonary hypertension (PH), so preventive actions are recommended. This study investigated the effectiveness of telemedicine and effects on quality of life (QOL) in the treatment of patients with PH. Methods and Results:Japanese patients with PH (n=40) were recruited from one referral center. Patient self-reported anxiety worsened significantly and elderly patients in particular experienced detrimental lifestyle changes under COVID-19. Telemedicine worked well to decrease the frequency of going out. Conclusions:Telemedicine is effective in reducing travel distances, and frequent remote interventions may be desirable for older, anxious patients.
Toraaki Okuyama, Kimiaki Komukai, Tomoki Maehara, Takahito Kamba, Keisuke Fukushima, Ritsu Yoshida, Yoshitsugu Oki, Keisuke Shirasaki, Takeyuki Kubota, Satoru Miyanaga, et al.
Published: 10 September 2020
Circulation Reports, Volume 2, pp 538-539; doi:10.1253/circrep.cr-20-0066

Abstract:
Japan's largest platform for academic e-journals: J-STAGE is a full text database for reviewed academic papers published by Japanese societies
Published: 10 September 2020
Circulation Reports, Volume 2; doi:10.1253/circrep.cr-2-content9

Abstract:
Japan's largest platform for academic e-journals: J-STAGE is a full text database for reviewed academic papers published by Japanese societies
Shintaro Yamada, Eriko Hasumi, Katsuhito Fujiu, Haruo Yamauchi, Issei Komuro
Published: 10 September 2020
Circulation Reports, Volume 2, pp 542-543; doi:10.1253/circrep.cr-20-0075

Osamu Tominaga, Eiichi Teshima, Atsuhiro Nakashima, Ryuji Tominaga
Published: 10 September 2020
Circulation Reports; doi:10.1253/circrep.cr-20-0059

Abstract:
Japan's largest platform for academic e-journals: J-STAGE is a full text database for reviewed academic papers published by Japanese societies
Hiroshi Kawakami, Makoto Saito, Satoshi Kodera, Akira Fujii, Takayuki Nagai, Teruyoshi Uetani, Sakurako Tanno, Yasunori Oka, Shuntaro Ikeda, Issei Komuro, et al.
Published: 10 September 2020
Circulation Reports, Volume 2, pp 507-516; doi:10.1253/circrep.cr-20-0074

Abstract:
Background:Although management of obstructive sleep apnea (OSA) has been recommended to improve outcomes of catheter ablation (CA) in patients with symptomatic atrial fibrillation (AF), the most cost-effective way of preprocedural OSA screening is undetermined. This study assessed the cost-effectiveness of OSA management before CA for symptomatic AF. Methods and Results:A Markov model was developed to assess the cost-effectiveness of 3 OSA detection strategies before CA: no screening; Type 3 portable monitor (PM)-guided screening; and polysomnography (PSG)-guided screening. The target population consisted of a hypothetical cohort of patients aged 65 years with symptomatic AF, with 50% prevalence of OSA. We used a 5-year horizon, with sensitivity analyses for significant variables and scenario analyses for lower and higher OSA prevalence (30% and 70%, respectively). In the base-case, both types of OSA screening were dominant (less costly and more effective) relative to no screening. Although PSG-guided management was more effective than PM-guided management, it was more costly and therefore did not show clear benefit. These findings were replicated in cohorts with lower and higher OSA risks. Conclusions:OSA screening before CA is cost-effective in patients with symptomatic AF, with PM screening being the most cost-effective. Physicians should consider OSA management using this simple tool in the decision making for treatment of symptomatic AF.
Yuuki Shimizu, Kazuhisa Kondo, Yoshihiro Fukumoto, Masayuki Takamura, Teruo Inoue, Tokuichiro Nagata, Yoshihiro J. Akashi, Yoshihiro Yamada, Koichiro Kuwahara, Yoshio Kobayashi, et al.
Published: 10 September 2020
Circulation Reports, Volume 2, pp 531-535; doi:10.1253/circrep.cr-20-0055

Abstract:
Background:Despite the growing knowledge regarding optimal treatments for critical limb ischemia (CLI), there are still a considerable number of patients who have to undergo major limb amputation. Intramuscular injection of autologous adipose-derived regenerative cells (ADRCs) in these patients has shown therapeutic potential in improving tissue ischemia, in both preclinical and initial pilot studies. Here, we present a clinical protocol for ADRCs use in a multicenter trial. Methods and Results:The TACT-ADRC multicenter trial is a prospective, interventional, single-arm, open-labeled study at 8 hospitals in Japan, investigating the safety and feasibility of intramuscular injections of ADRCs and testing the hypothesis that this treatment promotes neovascularization and improves major amputation-free survival rates in patients with CLI who have no other treatment option. 40 patients with CLI will be enrolled and followed up from November 2015 to November 2020. Freshly isolated autologous ADRCs will be injected into the target ischemic limbs. Survival rate, adverse events, major limb amputation, ulcer size, 6-min walking distance, numerical rating scale, ankle–brachial pressure index, skin perfusion pressure and digital subtraction angiography will be evaluated at baseline and during 6 months’ follow-up. Conclusions:This trial will demonstrate whether implantation of autologous ADRCs is a safe and effective method for therapeutic angiogenesis, resulting in an improvement in major amputation-free survival rates in patients with CLI.
Akihiro Sunaga, Shungo Hikoso, Daisaku Nakatani, Koichi Inoue, Yuji Okuyama, Yasuyuki Egami, Kazunori Kashiwase, Akio Hirata, Masaharu Masuda, Yoshio Furukawa, et al.
Published: 10 September 2020
Circulation Reports, Volume 2, pp 457-465; doi:10.1253/circrep.cr-20-0036

Abstract:
Background:Anticoagulation for patients with atrial fibrillation (AF) complicated by left atrial thrombi (LAT) is a frequent cause of bleeding complications, but risk factors remain unknown. Methods and Results:Of 3,139 AF patients who underwent transesophageal echocardiography, 82 with LAT under anticoagulation were included in this study. Patients treated with combination antiplatelet and anticoagulant therapy (n=31) were compared with those receiving anticoagulant monotherapy (n=51) to investigate the effects of antiplatelet agents during anticoagulation on bleeding complications. Over a mean (±SD) follow-up of 878±486 days, bleeding events occurred more frequently in the combination therapy than monotherapy group (58% vs. 20%; P
Hiroyuki Nakayama, Yuji Nishimoto, Kozo Hotta, Yukihito Sato
Published: 8 September 2020
Circulation Reports; doi:10.1253/circrep.cr-20-0033

Abstract:
Background:Early intervention with enteral nutrition (EN) is the standard of care in many medical intensive care units (ICUs). However, few studies have addressed the use of early EN for critically ill patients in the cardiac ICU (CICU). In this study we explored the indications for early EN for patients admitted to a CICU. Methods and Results:This retrospective observational study included 63 consecutive patients admitted to the CICU who were diagnosed with cardiovascular disease. Early EN was initiated in these patients as per the hospital’s nutrition protocol. Mean Acute Physiology and Chronic Health Evaluation (APACHE) II and Sequential Organ Failure Assessment (SOFA) scores at admission were 18.8 and 9.1, respectively. All patients were admitted to the medical CICU with a diagnosis of cardiovascular disease and/or cardiopulmonary arrest. Enteral feeding was initiated in 59 patients (94%) within 5 days of admission. Fifty-two patients (83%) achieved the energy intake goal at Day 7 of their CICU admission either by enteral feeding or oral intake; 49 patients (78%) survived to time of discharge. The patients experienced several minor complications, including minor reflux (4 patients; 6%) and diarrhea (8 patients; 13%). None of the patients developed aspiration pneumonia or bowel ischemia. Conclusions:The present retrospective observational study indicates that early EN for critically ill patients in a medical CICU can be achieved safely with no major complications.
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