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(searched for: doi:10.1016/j.jep.2017.09.005)
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Published: 5 January 2022
Natural Product Research, Volume 36, pp 5647-5664; https://doi.org/10.1080/14786419.2021.2022669

Abstract:
Teucrium L (Lamiaceae) is mainly distributed in the Mediterranean area. A comprehensive survey in the electronic databases (during 2000–2020 years) with keywords of ‘Teucrium’ and ‘Germander’ showed that chemical analyses are available for 27 species, with sesquiterpenoids, iridoids, di and triterpenoids, and phenolic compounds as identified structures. The neo-clerodane diterpenoids as potential chemotaxonomic markers were the main compounds of this genus. As a result, Italy and Turkey have good attempts at phytochemical analysis. The pharmacological activities of different species including antioxidant, cytotoxic activity, antidiabetic, antimicrobial, anti-inflammatory and anti-insect have been summarized. Teucrium polium and Teucrium chamaedrys mainly have been used in digestive problems and diabetes in traditional medicine. Evidence-based clinical trials are needed to confirm the therapeutic properties of this genus. As well to the popularity of Asian and Anatolian species as ingredients in contemporary medicines and products, further research is required in comparison to European species. Graphical Abstract
Published: 25 November 2021
by MDPI
Journal: Horticulturae
Abstract:
Anxiety and insomnia are among the most common mental health disorders and are a major cause of disability around the world. Traditional herbal medicines are receiving significant attention in global health debates. Several Italian regions maintain rural traditions and are among the most extensively studied areas of Europe regarding medicinal plant uses. The present overview aims to highlight the use of wild and cultivated plants, specifically as sedatives and for insomnia treatment in Italy, and to collect, analyze, and summarize the available literature about their pharmacological activity as well as clinical and pre-clinical studies concerning the most cited plants. In total, 106 wild taxa are used in Italy for sedative purposes. The plant species belong to 76 genera and 32 families, of which the most cited are Asteraceae (24.2%) and Lamiaceae (21.1%). Leaves (29%) and flowers (27%) are the plant parts mostly used as infusion (70%) and decoction (25%). Out of 106 taxa documented, only the most cited are analyzed in this overview (A. arvensis L., C. nepeta L., C. monogyna Jacq., H. lupulus L., L. nobilis L., L. angustifolia Mill., M. sylvestris L., M. chamomilla L., M. officinalis L., O. basilicum L., P. rhoeas L., P. somniferum L., R. officinalis L., T. platyphyllus Scop., and V. officinalis L.). Among the fifteen species selected, only seven have been studied for their pharmacological activity as hypnotic-sedatives. Future pre-clinical and clinical studies are needed to better clarify the mechanism of action of bioactive compounds and confirm the potential of these alternative therapies.
Published: 1 August 2021
Journal of Ethnopharmacology, Volume 276; https://doi.org/10.1016/j.jep.2021.114165

Abstract:
In Latin American Traditional Medicine, the use of Burseraceae oleoresins for headache relief is widespread. In the quilombola (maroon) communities of the municipality of Oriximiná, Pará State, Brazil, Burseraceae oleoresins are burned as incenses to treat headache; an effect attained by inhaling the smokes. This study was designed to investigate the scientific rationale behind the use of Burseraceae pitch oleoresin smokes on headache by identifying its chemical constituents and discussing whether they could be beneficial for headache treatment. Two samples of pitch oleoresins were purchased from Amazonian public markets; one of them marketed as "breu preto" (black pitch), and the other as "breu branco" (white pitch). The smoke headspaces produced upon burning these oleoresins were collected and analysed by GC-MS. For comparative purposes, the triterpenoid fingerprints of the oleoresins' dichloromethane extracts and profiles of the essential oils were also obtained by GC-MS - and GC-FID, in the case of the essential oils. A total of 32 compounds were detected in black and white pitch oleoresin smokes. All smoke headspaces of the pitch oleoresins shared the presence of volatile terpenoids (e.g., α-terpineol) and triterpenoids (e.g., α-amyrin, β-amyrin, α-amyrone, and β-amyrone). These compounds were also present in the crude resins and could potentially be responsible for anti-inflammatory, antinociceptive and analgesic effects on headache. The pharmacological data on the terpenoids detected in the Burseraceae pitch smokes strongly support their traditional use for headache, but their actual effects upon inhalation have yet to be determined.
Lubna Tariq, Basharat Ahmad Bhat, Syed Suhail Hamdani, Rakeeb Ahmad Mir
Published: 28 March 2021
The publisher has not yet granted permission to display this abstract.
Samaneh Kahromi,
Published: 21 December 2020
Journal of the Science of Food and Agriculture, Volume 101, pp 3898-3907; https://doi.org/10.1002/jsfa.11030

Abstract:
BACKGROUND A wide variety of secondary metabolites are synthesized from primary metabolites by plants which have a vast range in pharmaceutical, food additive and industrial applications. In recent years, the use of elicitors has opened a novel approach for the production of secondary metabolite compounds. Dracocephalum kotschyi is a valuable herb due to pharmaceutical compounds like rosmarinic acid, quercetin and apigenin. In the current study, foliar application of chitosan (0, 100, 400 mg L−1) as an elicitor was used. RESULTS After chitosan treatment, the amounts of hydrogen peroxide (H2O2) increased and the plant was able to increase the activities of enzymatic (guaiacol peroxidase, catalase and phenylalanine ammonium lyase) and non‐enzymatic (total phenols and flavonoids) defensive metabolites. Also, foliar spray of chitosan promoted nutrient absorption which led to the accumulation of macroelements in the plant. CONCLUSIONS Chitosan was found to be a very effective elicitor for improving rosmarinic acid and quercetin content (up to 13‐fold). Also, the content of apigenin (anticancer flavonoid) showed 16‐fold enhancement compared to the control. Therefore, the treatment of D. kotschyi leaves with chitosan caused a very large increase in the induction and production of important pharmaceutical compounds such as rosmarinic acid and quercetin. © 2020 Society of Chemical Industry
Published: 1 June 2020
Journal: Heliyon
Abstract:
Stellaria media Vill. is a representative of Caryophyllaceae family. The plant is widely dispersed all over the world and has been used as therapeutic substance since time immemorial. This review is aimed at exploring the chemical constituents and pharmacological activities of S. media. The findings revealed important secondary metabolites such as flavonoid, oligosaccharide stellariose, anthraquinone derivatives, fatty acid, steroid saponins and phenolic compounds. These bioactive metabolites displayed diverse pharmacological activities such as anti-obesity, antifungal, antibacterial, antioxidant, anti-proliferative, anti-inflammatory, analgesic, antidiabetic and anxiolytic activities. All findings revealed that S. media is a major species of Caryophyllaceae family. However, bioactive constituents and pharmacological potential of are not well appraised. Hence, extracts with established pharmacological activities should be subjected to bioassay guided isolation so as to obtain compounds with novel structural moieties prior to toxicogenetic appraisals.
, Ram A. Sharma
Published: 15 December 2019
Phytotherapy Research, Volume 34, pp 924-1007; https://doi.org/10.1002/ptr.6579

The publisher has not yet granted permission to display this abstract.
Rosalucia Mazzei, Marco Leonti, Santo Spadafora, Alessandra Patitucci,
Published: 29 November 2019
Journal of Ethnopharmacology, Volume 250; https://doi.org/10.1016/j.jep.2019.112443

Abstract:
Before the advent of modern antibiotics, microbial infections were treated with herbal medicine or cauterization. Literature from the latter half of the nineteenth to the early mid-twentieth century, when antibiotics became widely available, arguably holds the most progressive information about herbal remedies to treat bacterial skin diseases. The corpus of literature produced in Italy during that period is not easily accessible and mostly out of print.
, Yıldız Erkan, Emin Uğurlu
Published: 23 October 2018
Environment, Development and Sustainability, Volume 22, pp 2099-2120; https://doi.org/10.1007/s10668-018-0279-8

The publisher has not yet granted permission to display this abstract.
Published: 22 October 2018
Phytotherapy Research, Volume 33, pp 72-80; https://doi.org/10.1002/ptr.6212

Abstract:
This review aimed at summarizing phytochemical reports and biological activities of Abelmoschus esculentus L. from the database sources. For this, an up‐to‐date search was made in the PubMed, Science Direct, MedLine, Scopus, and Google Scholar. The findings suggest that A. esculentus contains various nutrients and important phytochemicals. It possesses a number of important biological activities, including antioxidant, anti‐inflammatory and immunomodulatory, antibacterial, anticancer, antidiabetic, organ protective, and neuropharmacological activities. Moreover, the plant also has lipid‐lowering, trypsin inhibitory, hemagglutinating, antiadhesive, and antifatigue activities. The fruit and seeds are well tolerated in humans and other animals. In conclusion, A. esculentus may be one of the best sources of pharmacologically active lead compounds. More research is necessary on its toxicogenetic effects in animals.
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