(searched for: doi:10.1080/07435800.2017.1292528)
Published: 20 October 2021
Journal of Pediatric Endocrinology and Metabolism, Volume 35, pp 55-63; https://doi.org/10.1515/jpem-2021-0581
Objectives: Vitamin D promotes both lipolysis and lipogenesis, and some pediatric studies showed inconsistent associations between vitamin D and metabolic syndrome (MetS). This cross-sectional study aimed to examine the association between vitamin D levels and MetS components among metropolitan adolescents. Methods: A total of 4,149 adolescents aged 10–18 years were recruited from 23 metropolises in China. The MetS conditions were assessed according to the International Diabetes Federation consensus definition, and the serum 25-hydroxy vitamin D (25(OH)D) concentrations were analyzed. The association between MetS components and serum 25(OH)D levels was analyzed by the logistic regression model. Restricted cubic spline was applied to the model nonlinear association. Results: Prevalence of vitamin D deficiency was 74.9%, and 41.2% of study participants had at least one MetS component. After adjustment, the significant trend for a lower waist-to-height ratio was not observed in study participants with higher serum 25(OH)D quartile (p=0.57), but a significant nonlinear association between abdominal obesity and serum 25(OH)D levels was found (p=0.04): the highest risk of abdominal obesity occurred at 14.1 ng/mL of serum 25(OH)D. The association of serum 25(OH)D was significantly inverse with MetS (OR: 0.95; 95% CI: 0.92–0.98), but not with raised triglycerides (OR: 0.99; 95% CI: 0.96–1.01), raised blood pressure (OR: 0.99; 95% CI: 0.97–1.01) and impaired fasting glycemia (OR: 1.03; 95% CI: 1.01–1.04). Conclusions: The net effect of vitamin D on lipid metabolism may be concentration-dependent, and the actual effect of vitamin D on MetS process may be complex among metropolitan adolescents, though serum 25(OH)D is inversely associated with MetS.
Journal of Clinical & Translational Endocrinology, Volume 19; https://doi.org/10.1016/j.jcte.2019.100213
To investigate the relationship between parathyroid gland weight and high-density lipoprotein (HDL) levels in patients with primary hyperparathyroidism (PHPT). In this retrospective case control study, we reviewed 329 PHPT patients aged from 20 to 85 years who had a parathyroidectomy at Robert Wood Johnson University Hospital. The patients were divided into 5 quintiles according to their parathyroid gland weight: 68 patients had a parathyroid gland weight <0.3 g, 66 patients had a gland weight 0.3–0.45 g, 67 patients had a gland weight 0.45–0.7 g, 63 patients had a gland weight 0.7–1.25 g, and 65 patients had a gland weight ≥1.25 g. Body Mass Index (BMI) trended to be higher across the quintiles of parathyroid gland weight (P = 0.003). Serum calcium and PTH levels were significantly increased across parathyroid gland quintiles (p < 0.0001). HDL levels tended to be lower across the increasing quintiles of parathyroid gland weight (P = 0.01). There was a negative relationship between log parathyroid gland weight and HDL in patients with PHPT in a simple linear regression (r = −0.160, P = 0.003). The negative association remained significant after adjustment for age and BMI (r = −0.114, P = 0.039). Furthermore, parathyroid gland weight was significantly associated with levels of triglyceride (r = 0.126, P = 0.02), but this relationship lost its significance after adjustment for age and BMI (r = 0.082, P ˃ 0.05). PHPT patients with heavier parathyroid glands tended to have higher BMI and lower HDL levels.
Diagnostic Pathology: Endocrine pp 362-371; https://doi.org/10.1016/b978-0-323-52480-3.50069-x