Refine Search

New Search

Results: 24

(searched for: doi:10.1001/archneurpsyc.1959.02340180012002)
Save to Scifeed
Page of 1
Articles per Page
by
Show export options
  Select all
Donna Johnstone, Evelyn Jaros, John B. Harris
Journal of the Neurological Sciences, Volume 73, pp 339-349; https://doi.org/10.1016/0022-510x(86)90158-9

Abstract:
Spontaneous electrical activity of tibialis anterior (TA) muscles was recorded using extracellular electrodes in dystrophic and phenotypically normal mice. Abnormal levels of spontaneous activity were recorded in the muscles of adult dystrophic mice. The activity was reduced by more than 75% after sciatic nerve section in anaesthetised dystrophic mice suggesting that most of the activity was neurally mediated. No abnormal activity was seen in the biceps brachii muscles of adult dystrophic mice. No abnormal spontaneous activity was seen in young (2-3-week-old) dystrophic mice. As degeneration of muscle fibres begins at about 7 days of age in dystrophic hindlimb muscles, the onset of the abnormal spontaneous EMG activity could not be considered causally related to muscle fibre degeneration.
H. -M. Meinck
Published: 1 October 1974
Journal of Molecular Medicine, Volume 52, pp 993-994; https://doi.org/10.1007/bf01468661

The publisher has not yet granted permission to display this abstract.
W. G. Bradley, T. A. Papapetropoulos, T. A. Papapetropoulos W. G. Bradley
Published: 1 April 1972
Nature, Volume 236, pp 401-402; https://doi.org/10.1038/236401a0

T. A. Papapetropoulos, W. G. Bradley
Journal of Neurology, Neurosurgery & Psychiatry, Volume 35, pp 60-65; https://doi.org/10.1136/jnnp.35.1.60

Abstract:
Recent electrophysiological studies of human and mouse muscular dystrophy have prompted the hypothesis that both are of neurogenic rather than myogenic origin. A decreased number of spinal motor neurones might be expected if this hypothesis were correct. The total number of neurones in the anterior grey horns of seven normal mice, six Bar Harbor 129 strain dystrophic mice, and six mice suffering from genetically-determined spinal muscular atrophy have been counted. The number of neurones in the cell types believed to include the motor neurones was significantly reduced to 13 to 71% of normal in mice with spinal muscular atrophy. In mice with muscular dystrophy, the number of anterior horn neurones was higher rather than lower than normal. The significance of these findings is discussed.
K. Ricker, H. M. Meinck
Published: 1 January 1972
Journal of Neurology, Volume 201, pp 62-72; https://doi.org/10.1007/bf00316722

The publisher has not yet granted permission to display this abstract.
A. J. McComas, R. E. P. Sica, S. Currie
Published: 1 June 1970
Nature, Volume 226, pp 1263-1264; https://doi.org/10.1038/2261263a0

W.W. Hofmann, W. Alston, G. Rowe
Electroencephalography and Clinical Neurophysiology, Volume 21, pp 521-537; https://doi.org/10.1016/0013-4694(66)90171-4

The publisher has not yet granted permission to display this abstract.
R. J. Lipicky, S. H. Bryant
Journal of General Physiology, Volume 50, pp 89-111; https://doi.org/10.1085/jgp.50.1.89

Abstract:
In isolated bundles of external intercostal muscle from normal goats and goats with hereditary myotonia the following were determined: concentrations and unidirectional fluxes of Na+, K+, and Cl-, extracellular volume, water content, fiber geometry, and core-conductor constants. No significant difference between the two groups of preparations was found with respect to distribution of fiber size, intracellular concentrations of Na+ or Cl-, fiber water, resting membrane potential, or overshoot of action potential. The intracellular Cl- concentration in both groups of preparations was 4 to 7 times that expected if Cl- were distributed passively between intracellular and extracellular water. The membrane permeability to K (PK) calculated from efflux data was (a) at 38°C, 0.365 x 10-6 cm sec-1 for normal and 0.492 x 10-6 for myotonic muscle, and (b) at 25°C, 0.219 x 10-6 for normal and 0.199 x 10-6 for myotonic muscle. From Cl- washout curves of normal muscle usually only three exponential functions could be extracted, but in every experiment with myotonic muscle there was an additional, intermediate component. From these data PPcl could be calculated; it was 0.413 x 10-6 cm sec-1 for myotonic fibers and was ⩾ 0.815 x 10-6 cm sec-1 for normal fibers. The resting membrane resistance of myotonic fibers was 4 to 6 times greater than that of normal fibers.
W. Wechsler, W. Pabelick
Published: 1 January 1966
The publisher has not yet granted permission to display this abstract.
Published: 30 March 1963
BMJ, Volume 1, pp 836-7

John T. Conrad, Gilbert H. Glaser, Gilbert H. Glaser John T. Conrad
Published: 1 December 1962
Nature, Volume 196, pp 997-998; https://doi.org/10.1038/196997a0

Page of 1
Articles per Page
by
Show export options
  Select all
Back to Top Top