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(searched for: doi:10.53933/sspmpm.v2i2.46)
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Jia-Peng Yang, Zhong Tian
Evidence-Based Complementary and Alternative Medicine, Volume 2022, pp 1-6; https://doi.org/10.1155/2022/2071326

Abstract:
Objective. To assess the effect of laparoscopic cholecystectomy for acute cholecystitis after percutaneous transhepatic gallbladder drainage (PTGBD). Methods. A total of 70 patients with acute cholecystitis diagnosed and treated in our hospital between April 2020 and November 2021 were recruited and assigned to receive either conventional treatment (conventional group) or PTGBD plus laparoscopic cholecystectomy (experimental group) according to the order of admission (with January 2021 as the cut-off time point), with 35 cases in each group. Outcome measures included treatment outcomes, surgical indices, and postoperative recovery. Results. Patients in the experimental group showed significantly less intraoperative hemorrhage volume and shorter operative time, time-lapse before passing gas, and hospital stay (83.15 ± 31.17, 32.54 ± 12.61, 23.02 ± 4.61, 7.98 ± 3.24) versus those in the conventional group (120.56 ± 30.55, 61.01 ± 15.54, 28.15 ± 5.91, 11.95 ± 4.15) ( P<0.05 ). The incidence of conversion to open surgery and postoperative drainage in the experimental group was significantly lower (2.86%, 5.71%) than that of the conventional group (25.71%, 45.71%) ( P<0.05 ). The differences in the postoperative body temperature of the two groups did not come up to statistical standard ( P>0.05 ). The experimental group had faster body temperature recovery and leukocyte recovery and better leukocyte levels (1.25 ± 0.56, 2.36 ± 0.48, 7.92 ± 1.36) than the conventional group (3.11 ± 1.05, 5.41 ± 0.63, 10.52 ± 2.78) ( P<0.05 ). There was 1 (2.86%) case of pneumothorax and 1 (2.86%) case of intestinal bleeding in the experimental group, and there were 2 (5.71%) cases of biliary leakage, 3 (8.57%) cases of pneumothorax, 4 (11.43%) cases of intestinal bleeding, 5.71% cases of incisional infection, 1 (2.86%) case of respiratory failure, and 1 (2.86%) case of liver damage in the conventional group. The experimental group showed a significantly lower incidence of complications (5.71%) versus the conventional group (37.14%) ( P<0.05 ). Conclusion. PTGBD plus laparoscopic cholecystectomy for acute cholecystitis effectively improves surgical safety, promotes patients' postoperative recovery, and reduces the incidence of conversion to open surgery and postoperative complications with a high safety profile. Further trials are, however, required prior to clinical promotion.
Valentyn Shapovalov
SSP Modern Law and Practice, Volume 2; https://doi.org/10.53933/sspmlp.v2i2.51

Abstract:
Deepening cooperation between the LMI, KhMAPE and the Estonian scientific publishing house SSP OÜ will be part of the system of Ukraine's integration into the European Community by building pharmaceutical companies for the production of domestic drugs. Integration of pharmaceutical production can take into account the problems and risks that arose during the creation of the common economic zone "Yavoriv" on the basis of state guarantees.
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