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(searched for: doi:10.29328/journal.hps.1001004)
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Márcio Robert Mattos Da Silva, Letícia Pereira Dysars, Elisabete Pereira Dos Santos,
Published: 1 January 2020
by SciELO
Brazilian Journal of Pharmaceutical Sciences, Volume 56; https://doi.org/10.1590/s2175-97902019000418358

Abstract:
At the hospital, the pharmacist is constantly challenged to prepare extemporaneous solutions from tablets, capsules or drug powder for patients unable to swallow, such as pediatric, elderly and patients that use nasoenteric and nasogastric tubes. The preparation of extemporaneous solutions from capsules, tablets and drug powder requires stability studies analysis. This article is a bibliographic review of preparation of extemporaneous oral liquid from solid oral dosage forms used in clinical practice. The selected articles contain all the information regarding manipulation techniques, pharmaceutical excipients, packaging, storage conditions and results of stability studies above 90% performed by HPLC analysis. In addition, a situational analysis of the strategies for the preparation of the extemporaneous solution was described to help the manipulator in the decision. The preparation of extemporaneous solution from solid oral dosage forms is based on information from official compendium or scientific literature, to ensure safe and effective manipulated medicine.
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