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Viktoriia Vivcharuk
Published: 30 December 2020
ScienceRise pp 59-67; doi:10.21303/2313-8416.2020.001553

Abstract:
The article discusses analysis of examinations and treatment results 100 children with hemangiomas different localizations on the different stages of existence. The study included patients of different ages, from birth to 6 years. Importance of primary assessment of severity and activity of hemangioma`s, for the choice of treatment, was considered. Correlation between clinical course of hemangiomas and soluble Fas/FasL was analyzed. The object of the research: Clinical course of hemangiomas of different morphological types, soluble form of Fas and FasL in the serum of patients with hemangiomas. Investigated problem: Improving the results of treatment of hemangiomas in children. The main scientific results: Predicting the course of hemangiomas in children allows to determine the need for treatment at different stages of their existence, as well as to carry out timely correction of the prescribed treatment to achieve good cosmetic and functional results. The area of practical use of the research results: Department of Pediatrics, Pediatric Surgery, Dermatology. Innovative technological product: Defined characteristics will help in predicting the course of hemangiomas and the effectiveness of their treatment. Scope of the innovative technological product: Clinical pediatric practice.
Dmytro Korol, Artem Yefimenko, Mykhailo Korol
Published: 30 December 2020
ScienceRise pp 68-73; doi:10.21303/2313-8416.2020.001558

Abstract:
The object of the study there is a level of hyperemia of the mucous membrane around the installed intraosseous dental implants with different coating material according to the results of histogram analysis of digital microscopy. The problem to be solved – evaluation of the degree of hyperemia of the periimplant mucosa around intraosseous dental implants coated with rutile, in comparison with titanium implants of VT-6 alloy after prosthetics. Main scientific results: Analysis of digital images using histogram evaluation of the red component of the spectrum showed that 1 month after prosthetics in group 1, which included 20 patients who had intraosseous implants made of titanium alloy TiV6Al (VT-6), the above indicator increased to 191 (St.Err. 4.45). The difference was 4 conventional units. Similarly, in group 2 (16 people) who had intraosseous zirconium implants, there was an increase in the quantitative rate after prosthetics by 9 conventional units, and its value was 194 conventional units (St.Err. 3.64). Since increasing numerical values ​​and shifting the digital histogram to the right is an objective criterion for reducing the intensity of redness, it can be concluded that there is a reduction of mucosal irritation after orthopedic treatment with a predominance of this process in the group of patients who received intraosseous dental implants coated with rutile. The area of practical use of research results: Since the authors first studied the reaction of the peri-implant mucosa in contact with various implant materials at the stages of orthopedic treatment, this is the basis for the introduction into general medical practice of intraosseous dental implants made in Ukraine using rutile application technology. The area of application of an innovative technological product - it is a dental implant practice. The obtained results will allow to use more widely Ukrainian implants of non-demountable construction with a high level of surface preparation, for the purpose of further orthopedic treatment with the use of non-removable metal-ceramic dentures.
Mariia Romanko, Zoia Rossokha, Iryna Maydan, Maryna Mamenko , Lyudmila Kvashnina
Published: 30 December 2020
ScienceRise pp 51-58; doi:10.21303/2313-8416.2020.001557

Abstract:
Object of the research: VDBP gene polymorphism. Problem being addressed: the effect of existing polymorphic variants of the VDBP gene on the absorption of vitamin D in young children. The main scientific results. At the beginning of the survey, vitamin D supplementation was performed in 50.0±9.1 % (15/30) of children. The concentration of 25 (OH) D in the serum of the subjects was 32.9 ng/ml (23.2–60.0). All patients with the GG rs 7041 genotype of the VDBP gene had a concentration of 25 (OH) D in the range of 20-100 ng/ml, which is statistically more common than in children with the AA rs 4588 genotype (p=0.015), GT rs 7041 genotype (p=0.047) and genotype TT rs 7041 (p=0.033). Patients with CA rs 4588 genotypes – 23.7 ng/ml (14.8-35.8) and GT rs 7041 – 28.1 ng/ml (17.1–49) had the lowest serum levels of 25 (OH) D, the highest levels of 25 (OH) D – children with genotype AA rs 4588 – 122.6 ng/ml (23.2–124.1) and genotype TT rs 7041 – 78.6 ng/ml (23.2 –124.1). Carriers of the AA rs 4588 genotype were more likely than patients with the GG rs 7041 genotype to show dangerously high levels of 25 (OH) D (p=0.069). Patients with the AA rs 4588 genotype had lower alkaline phosphatase levels compared to the GT rs 7041 and CC rs 4588 genotypes – 185.0 U/l (147.0–212.0) versus 259.5 U/l (207.0–334.5), p=0.021 and against 251.0 U/l (222.0–346.0), p=0.016. Area of practical application of research results: The results of the study can be used by working groups to make recommendations for the prevention and treatment of vitamin D deficiency and in the practice of health care facilities. Innovative technological product: association between allelic variants of the VDBP gene and vitamin D status in young children. Scope of application of innovative technological product: pediatrics, medical genetics. Conclusions. Genetic variants of VDBP may affect the absorption of vitamin D and cause variability in 25 (OH) D levels, which complicates the development of uniform recommendations for optimal prophylactic doses of vitamin D and necessitates additional research. The highest levels of 25 (OH) D were recorded in children with genotypes AA rs 4588 and TT rs 7041 of the VDBP gene, which showed high absorption when taking vitamin D supplements at a dose of 500 IU and even excessive concentrations of 25 (OH) D with long-term supplementation in higher dose.
Olena Kuzenko, Yuri Demin, Yevhen Kuzenko
Published: 30 December 2020
ScienceRise pp 31-39; doi:10.21303/2313-8416.2020.001549

Abstract:
Intoxication lesions of the optic nerve (toxic optic neuropathy, TON) most often occur under the influence of exogenous factors, including heavy metals. Сell survival under stress have involves heat shock proteins (HSPs). The aim of the research. To assess the optic nerve’s immunoreactivity to heat shock proteins of the HSP70 and HSP90α families and reveal its relationship with the severity of morphological changes in toxic optic neuropathy caused by Cr (VI). Materials and methods. The study was conducted on 48 mature male rats. The experimental groups were given to drink water with Cr(VI) for 20, 40 and 60 days. This type of water is typical for the water basins in the northern districts of the Sumy region. Optic nerves сhanges under the influence of Cr(VI) have investigated by the morphometric method. Neuroglial cells and capillary endothelial cells were assessed by immunohistochemistry by HSP70α and HSP90 expression for intensity and spatial distribution. Results. The data analysis revealed that Cr (VI) has a neurotoxic effect on the optic nerve with the development of edema, which is manifested by the thickening of nerve fibers. The dynamics of HSP70 immunoexpression in the endothelium of the optic nerve capillaries of rats on 20 and 40 experimental days was characterized by stable values and was 1.5 times higher than the control. The maximum number of positively stained cells for the HSP70 marker was detected in endothelial cells of the microvasculature for 60 days – 82.44±12.42 %. HSP70 levels in neuroglia cells of optic nerve have decreased on day 40 (55.66±11.56% p=0.05) and lower than the control (70.44±4.81 %.) group. Optic nerve capillaries was highest immunoactivity on HSP90 in group II endothelial cells – 51.22±14.57% (p=0.05). The activity of HSP90α protein in optic neuroglia cells was characterized by a gradual increase in the duration of the experiment and was higher by 12, 4 % in experimental group III (81.77±21.67 %) compared with control (71.66±4.95 %). Conclusions. Our study provides an insight into the significant difference in the immunoreactivity of heat shock proteins of the HSP70 and HSP90α families in neuroglia and endothelial cells of the optic nerve capillaries under the influence of Cr(VI). The results obtained suggest that Cr (VI) has a neurotoxic effect on the optic nerve with the development of edema, which is manifested by the thickening of nerve fibers. A comparison of the dynamics of the development of the dystrophic process in the optic nerve with the results of the immunohistochemical analysis showed, that an increase in the thickness of nerve fibers is accompanied by an increase in immunoreactive neuroglial cells (HSP90α) and endothelial cells (HSP70).
Valery Boyko , Yuri Skibo, Aleksandr Pyetkov, Andrey Krasnoyaruzskiy
Published: 30 December 2020
ScienceRise pp 25-30; doi:10.21303/2313-8416.2020.001556

Abstract:
The object of the study: coronary revascularization in patients with malignant lung diseases and concomitant ischemic heart disease. The problem to be solved: selection of the optimal tactics for coronary bypass grafting simultaneously with lung resections. Main scientific results: an individual approach to the choice of tactics for carrying out simultaneous operations in patients with malignant lung diseases and concomitant ischemic heart disease is proposed. It has been shown that performing coronary artery bypass grafting simultaneously with lung resections, according to the proposed methods, allows minimizing surgical trauma and eliminating the influence of additional risk factors associated with cardiopulmonary bypass (CPB). The area of practical use of research results: surgical hospitals. An innovative technological product: methods for performing simultaneous coronary (artery) bypass grafting in patients with malignant lung diseases, based on the use of sternotomy, thoracotomy and mini-thoracotomy approaches. The area of application of an innovative technological product: clinical practice of performing simultaneous operations for combined pathology of the heart and lungs in medical institutions of a general surgical profile.
Asif Baglar Ogly Mansyrov, Viktor Lytovchenko, Yevgeniy Garyachiy, Andriy Lytovchenko
Published: 30 December 2020
ScienceRise pp 40-50; doi:10.21303/2313-8416.2020.001559

Abstract:
The object of the study: clinical effect of intramedullary blocking osteosynthesis of fractures of the bones of the extremities without reaming of the bone marrow canal. The problem to be solved: determination of the influence of surgical technology of intramedullary blocking osteosynthesis of bone fractures without reaming of the bone marrow canal on the qualitative and anatomical and functional results of treatment. Main scientific results. The term of fusion of bone fragments in complete groups (including all localizations) in the group of patients who underwent surgery with reaming of the bone marrow canal was 4.21±0.46 months, while in the group without reaming of the canal it was much shorter – 3.47±0.51 months Faster functional recovery of the limbs was also observed in cases that precluded bone marrow reaming – 96 % of good and 4 % satisfactory scores were obtained (80 % good and 20 % satisfactory in bone marrow reaming). The technology of closed intramedullary blocking osteosynthesis without reaming of the bone marrow can optimize the time of fusion of bone fragments and get 91 % good and 9 % satisfactory results. Its effectiveness is to reduce the number of satisfactory treatment results by 19 %, the absence of unsatisfactory and increase the share of good results by 23 %. The area of practical use of research results: clinics of traumatological profile of different levels, in which surgical treatment of fractures of the bones of the extremities are done. An innovative technological product: technology of closed intramedullary blocking osteosynthesis without reaming of the bone marrow canal. The area of application of an innovative technological product: clinical practice of using the technology of closed intramedullary blocking osteosynthesis without reaming of the bone marrow canal.
Dariia Liashko
Published: 30 December 2020
ScienceRise pp 74-80; doi:10.21303/2313-8416.2020.001561

Abstract:
The object of the study. Experimental research of music therapy methods. The problem to be solved. Determining the influence of selected musical composition of the audible frequency spectrum on the bioelectrical activity of students' brains, in particular alpha-, beta- and theta-rhythms. Main scientific results. The dependence of the influence on the bioelectrical activity of the brain of the compositions of the three frequency bands both individually and the composition as a whole is revealed. The dependence of alpha, beta and theta rhythms is shown. The area of ​​practical use of the research results. Medical institutions specializing in the treatment of disorders of the central nervous system, organic brain damage, stress, and its effective psychological rehabilitation. An innovative technological product. A technique of music therapy that allows to determine how different frequency ranges affect the bioelectrical activity of the human brain. The area of application of an innovative technological product. Clinical practice of using a music therapy.
Svitlana Shapovalova, Yurii Moskalenko
Published: 30 December 2020
ScienceRise pp 10-16; doi:10.21303/2313-8416.2020.001550

Abstract:
Object of research: basic architectures of deep learning neural networks. Investigated problem: insufficient accuracy of solving the classification problem based on the basic architectures of deep learning neural networks. An increase in accuracy requires a significant complication of the architecture, which, in turn, leads to an increase in the required computing resources, as well as the consumption of video memory and the cost of learning/output time. Therefore, the problem arises of determining such methods for modifying basic architectures that improve the classification accuracy and require insignificant additional computing resources. Main scientific results: based on the analysis of existing methods for improving the classification accuracy on the convolutional networks of basic architectures, it is determined what is most effective: scaling the ScanNet architecture, learning the ensemble of TreeNet models, integrating several CBNet backbone networks. For computational experiments, these modifications of the basic architectures are implemented, as well as their combinations: ScanNet + TreeNet, ScanNet + CBNet. The effectiveness of these methods in comparison with basic architectures has been proven when solving the problem of recognizing malignant tumors with diagnostic images – SIIM-ISIC Melanoma Classification, the train/test set of which is presented on the Kaggle platform. The accuracy value for the area under the ROC curve metric has increased from 0.94489 (basic architecture network) to 0.96317 (network with ScanNet + CBNet modifications). At the same time, the output compared to the basic architecture (EfficientNet-b5) increased from 440 to 490 seconds, and the consumption of video memory increased from 8 to 9.2 gigabytes, which is acceptable. Innovative technological product: methods for achieving high recognition accuracy from a diagnostic signal based on deep learning neural networks of basic architectures. Scope of application of the innovative technological product: automatic diagnostics systems in the following areas: medicine, seismology, astronomy (classification by images) onboard control systems and systems for monitoring transport and vehicle flows or visitors (recognition of scenes with camera frames).
Larysa Bogush
Published: 30 December 2020
ScienceRise pp 17-24; doi:10.21303/2313-8416.2020.001497

Abstract:
Object of research: the article presents the results of studying the economic rent from workforce and social conditions (significant components of the important rent-forming resource of nowadays global economy – social capital) in Ukraine. Solved problem: determining the features of economic rent, outlining the conditions and prospects for increasing the rental income of the Ukrainian economy from the capitalization of workforce’ intellectual and creative qualities, as well as socium rent-generating conjunctures. Main scientific results: the role of the economic rent in the system of rental relations of the modern global economy and its national components is examined; the features of the formation and distribution of economic rent’ various types in the process of using the workforce’ intellectual and creative potential, as well as other components of the nowadays most significant type of rent-forming resources – social capital – are studied. The specificity of human component and social capital in general as a rent-generating resource is manifested in the generation of additional prerequisites (resource, organizational and economic) and incentives to increase volumes and expand potential areas for extracting rent income in the process of its use, since the using of the employee’ knowledge and abilities leads to a consistent accumulation of professional experience, and consequently – to a permanent increase in the aggregate of these rent-generating properties and in activities for improving the environment of their implementation in Ukraine. Scope of practical use of research results: the research results can be used in developing strategies and programs of Ukrainian economy’ innovative diversification in the process of its further competitive integration into the global economic space, that, among other things, requires the creation of conditions for improving the rent-generating properties of workforce and social environment, as well as increasing the level of its capitalization.
Serhii Kovalov
Published: 30 December 2020
ScienceRise pp 3-9; doi:10.21303/2313-8416.2020.001551

Abstract:
The object of research is the multifunctional synthesis technology Avenir Gaz (of various levels of complexity), intended for converting transport diesel engines into spark-ignited gas internal combustion engines (ICE) for operation on liquefied petroleum gas (LPG). Investigated problem: the creation of an affordable synthesis technology in terms of complexity and price, which allows converting operating diesel engines into gas internal combustion engines operating on cheaper and environmentally friendly gas fuel - LPG. Main scientific results: Avenir Gaz synthesis technology (two levels of complexity, qualified as levels "A" and "B") for converting diesel engines into gas internal combustion engines is developed and created. It is shown that the conversion of diesel engines according to the Avenir Gaz synthesis technology is carried out on the basis of the developed electronic microprocessor control systems. And the basis of the control systems is the developed and manufactured two electronic microprocessor control units Avenir Gaz 37 (hereinafter – ECU Avenir Gaz 37). ECUs in accordance with the levels of complexity of synthesis technology are qualified as – ECUs Avenir Gaz 37 "A" and Avenir Gaz 37 "B". It is shown that Avenir Gaz synthesis technology of level "A" allows converting diesel engines into gas internal combustion engines with LPG supply through a gas-air mixer into the inlet pipeline. At the same time, the Avenir Gaz 37 "A" ECU, using the signal from the Hall sensor of the distributor, limits the maximum speed of the gas engine, thereby ensuring its safe operation. And the synthesis technology Avenir Gaz 37 of level "B" allows converting diesel engines into gas internal combustion engines providing group or sequential injection of LPG by electromagnetic gas nozzles (injection system of the Common Rail type) into the intake manifold in the area close to the intake valve. Area of practical use of the research results: converting diesel vehicles, including agricultural machinery (powerful wheeled and tracked tractors, combines, etc.) into spark-ignited gas combustion engines operating on LPG. An innovative technological product: Avenir Gaz synthesis technology, which allows converting the transport diesel engines in operation into gas internal combustion engines for operation on LPG. Scope of application of the innovative technological product: naturally aspirated and supercharged diesel engines with the number of cylinders from one to six, in-line and V-shaped, with a uniform alternation of working strokes.
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