Refine Search

New Search

Results: 17,733,353

(searched for: doi:(10.1016/*))
Save to Scifeed
Page of 354,668
Articles per Page
by
Show export options
  Select all
Xupeng Bai, Jie Ni, Julia Beretov , Peter Graham, Yong Li
Published: 28 January 2021
Cancer Letters, Volume 497, pp 100-111; doi:10.1016/j.canlet.2020.10.016

The publisher has not yet granted permission to display this abstract.
Yi Yuan, Xushan Cai, Fangrong Shen , Feng Ma
Published: 28 January 2021
Cancer Letters, Volume 497, pp 243-254; doi:10.1016/j.canlet.2020.10.034

The publisher has not yet granted permission to display this abstract.
Ding Ding, Ammar A. Javed, Dea Cunningham, Jonathan Teinor, Michael Wright, Zunaira N. Javed, Cara Wilt, Lindsay Parish, Mary Hodgin, Amy Ryan, et al.
Published: 28 January 2021
Cancer Letters, Volume 497, pp 221-228; doi:10.1016/j.canlet.2020.10.039

Abstract:
Recent research on genomic profiling of pancreatic ductal adenocarcinoma (PDAC) has identified many potentially actionable alterations. However, the feasibility of using genomic profiling to guide routine clinical decision making for PDAC patients remains unclear. We retrospectively reviewed PDAC patients between October 2013 and December 2017, who underwent treatment at the Johns Hopkins Hospital and had clinical tumor next-generation sequencing (NGS) through commercial resources. Ninety-two patients with 93 tumors tested were included. Forty-eight (52%) patients had potentially curative surgeries. The median time from the tissue available to the NGS testing ordered was 229 days (interquartile range 62–415). A total of three (3%) patients had matched targeted therapies based on genomic profiling results. Genomic profiling guided personalized treatment for PDAC patients is feasible, but the percentage of patients who receive targeted therapy is low. The main challenges are ordering NGS testing early in the clinical course of the disease and the limited evidence of using a targeted approach in these patients. A real-time department level genomic testing ordering system in combination with an evidence-based flagging system for potentially actionable alterations could help address these shortcomings.
Mohsen Amini , Morteza Soltani, Samira Baninajarian, Mohsen Rezaei
Published: 28 January 2021
Physics Letters A, Volume 387; doi:10.1016/j.physleta.2020.127012

The publisher has not yet granted permission to display this abstract.
Published: 28 January 2021
Physics Letters A, Volume 387; doi:10.1016/j.physleta.2020.127024

The publisher has not yet granted permission to display this abstract.
Published: 28 January 2021
Physics Letters A, Volume 387; doi:10.1016/j.physleta.2020.127005

The publisher has not yet granted permission to display this abstract.
Aleksandra Gajić , Jelena Radovanović, Nikola Vuković, Vitomir Milanović, Dmitri L. Boiko
Published: 28 January 2021
Physics Letters A, Volume 387; doi:10.1016/j.physleta.2020.127007

The publisher has not yet granted permission to display this abstract.
V.V. Semak, M.N. Shneider
Published: 28 January 2021
Physics Letters A, Volume 387; doi:10.1016/j.physleta.2020.127031

The publisher has not yet granted permission to display this abstract.
D.S. Acosta Coden, S.S. Gómez, A. Ferrón , O. Osenda
Published: 28 January 2021
Physics Letters A, Volume 387; doi:10.1016/j.physleta.2020.127009

The publisher has not yet granted permission to display this abstract.
Published: 28 January 2021
Physics Letters A, Volume 387; doi:10.1016/j.physleta.2020.127011

The publisher has not yet granted permission to display this abstract.
Hang Li, Jia Guo, Shushu Chu, Hui Li, Qi Zhang, Ziqiong Lin, Qian Ma
Published: 28 January 2021
Physics Letters A, Volume 387; doi:10.1016/j.physleta.2020.127023

The publisher has not yet granted permission to display this abstract.
Published: 28 January 2021
Physics Letters A, Volume 387; doi:10.1016/j.physleta.2020.127036

The publisher has not yet granted permission to display this abstract.
Published: 28 January 2021
Physics Letters A, Volume 387; doi:10.1016/s0375-9601(20)30931-2

Mengqi Li, Shoukun Wang, Qinhuan Wang, Fuqiang Ren, Yu Wang
Published: 28 January 2021
Materials Science and Engineering: A, Volume 803; doi:10.1016/j.msea.2020.140699

The publisher has not yet granted permission to display this abstract.
Yajing Zhang, Shengmin Fang, Yiming Wang, Deliang Zhang
Published: 28 January 2021
Materials Science and Engineering: A, Volume 803; doi:10.1016/j.msea.2020.140701

The publisher has not yet granted permission to display this abstract.
Xinglong An, Yan Li, Song Ni , Zhangwei Wang, Min Song
Published: 28 January 2021
Materials Science and Engineering: A, Volume 803; doi:10.1016/j.msea.2020.140712

The publisher has not yet granted permission to display this abstract.
Shuya Zhang, Xin Lin , Lilin Wang , Xiaobin Yu, Haiou Yang , Liming Lei, Weidong Huang
Published: 28 January 2021
Materials Science and Engineering: A, Volume 803; doi:10.1016/j.msea.2020.140702

The publisher has not yet granted permission to display this abstract.
Thanh Thuong Huynh, Shigeru Hamada, Kaneaki Tsuzaki, Hiroshi Noguchi
Published: 28 January 2021
Materials Science and Engineering: A, Volume 803; doi:10.1016/j.msea.2020.140703

The publisher has not yet granted permission to display this abstract.
Junko Umeda, Takayuki Tanaka, Takuma Teramae, Shota Kariya, Junji Fujita, Hiroshi Nishikawa, Yoji Shibutani, Jianghua Shen , Katsuyoshi Kondoh
Published: 28 January 2021
Materials Science and Engineering: A, Volume 803; doi:10.1016/j.msea.2020.140708

The publisher has not yet granted permission to display this abstract.
Jiapeng Sun , Bangjun Li, Jie Yuan, Xiankai Li, Bingqian Xu, Zhenquan Yang, Jing Han , Jinghua Jiang, Guosong Wu, Aibin Ma
Published: 28 January 2021
Materials Science and Engineering: A, Volume 803; doi:10.1016/j.msea.2020.140707

The publisher has not yet granted permission to display this abstract.
Published: 28 January 2021
Materials Science and Engineering: A, Volume 803; doi:10.1016/j.msea.2020.140715

The publisher has not yet granted permission to display this abstract.
Weidong Xuan , Ge Song, Fangmiao Duan, Zude Xiao, Wenxuan Pan, Yajun Zhang, Chuanjun Li, Jiang Wang, Zhongming Ren
Published: 28 January 2021
Materials Science and Engineering: A, Volume 803; doi:10.1016/j.msea.2020.140729

The publisher has not yet granted permission to display this abstract.
Published: 28 January 2021
Materials Science and Engineering: A, Volume 803; doi:10.1016/j.msea.2020.140700

The publisher has not yet granted permission to display this abstract.
Chun Cheng , Kota Kadoi, Hidetoshi Fujii, Kohsaku Ushioda, Hiroshige Inoue
Published: 28 January 2021
Materials Science and Engineering: A, Volume 803; doi:10.1016/j.msea.2020.140689

The publisher has not yet granted permission to display this abstract.
Ruizhe Su, Dajla Neffati, Yifan Zhang, Jaehun Cho, Jin Li, Haiyan Wang, Yashashree Kulkarni, Xinghang Zhang
Published: 28 January 2021
Materials Science and Engineering: A, Volume 803; doi:10.1016/j.msea.2020.140696

The publisher has not yet granted permission to display this abstract.
Published: 28 January 2021
Materials Science and Engineering: A, Volume 803; doi:10.1016/j.msea.2021.140768

Published: 28 January 2021
Cancer Letters, Volume 497, pp 165-177; doi:10.1016/j.canlet.2020.10.021

The publisher has not yet granted permission to display this abstract.
Jayoung Song, Jinha Yu, Lak Shin Jeong, Sang Kook Lee
Published: 28 January 2021
Cancer Letters, Volume 497, pp 54-65; doi:10.1016/j.canlet.2020.10.003

The publisher has not yet granted permission to display this abstract.
Maureen Van De Velde, Marie Ebroin, Tania Durré, Marc Joiret , Lionel Gillot, Silvia Blacher, Liesbet Geris , Frédéric Kridelka, Agnès Noel
Published: 28 January 2021
Cancer Letters, Volume 497, pp 154-164; doi:10.1016/j.canlet.2020.10.020

Abstract:
Solid tumors are composed of tumor cells and stromal cells including lymphatic endothelial cells (LEC), which are mainly viewed as cells forming lymphatic vessels involved in the transport of metastatic and immune cells. We here reveal a new mechanism by which tumor exposed-LEC (teLEC) exert mitogenic effects on tumor cells. Our conclusions are supported by morphological and molecular changes induced in teLEC that in turn enhance cancer cell invasion in 3D cultures and tumor cell proliferation in vivo. The characterization of teLEC secretome by RNA-Sequencing and cytokine array revealed that interleukine-6 (IL6) is one of the most modulated molecules in teLEC, whose production was negligible in unexposed LEC. Notably, neutralizing anti-human IL6 antibody abrogated teLEC-mediated mitogenic effects in vivo, when LEC were mixed with tumor cells in the ear sponge assay. We here assign a novel function to teLEC that is beyond their role of lymphatic vessel formation. This work highlights a new paradigm, in which teLEC exert “fibroblast-like properties”, contribute in a paracrine manner to the control of tumor cell properties and are worth considering as key stromal determinant in future studies.
Rong Luo, Jian-Rong Yang, Tong-Biao Wang , De-Jian Zhang, Wen-Xing Liu, Tian-Bao Yu, Qing-Hua Liao
Published: 28 January 2021
Physics Letters A, Volume 387; doi:10.1016/j.physleta.2020.127006

The publisher has not yet granted permission to display this abstract.
Published: 28 January 2021
Physics Letters A, Volume 387; doi:10.1016/j.physleta.2020.127008

The publisher has not yet granted permission to display this abstract.
Published: 28 January 2021
Physics Letters A, Volume 387; doi:10.1016/j.physleta.2020.127026

The publisher has not yet granted permission to display this abstract.
Li-Mei Zhang, Ting Gao , Feng-Li Yan
Published: 28 January 2021
Physics Letters A, Volume 387; doi:10.1016/j.physleta.2020.127029

The publisher has not yet granted permission to display this abstract.
Published: 28 January 2021
Physics Letters A, Volume 387; doi:10.1016/j.physleta.2020.127037

The publisher has not yet granted permission to display this abstract.
U. Jain , N. Keskar, B. Vishwanadh, K.V. Mani Krishna, C. Gupta, A.K. Sinha, R. Tewari, D. Banerjee
Published: 28 January 2021
Materials Science and Engineering: A, Volume 803; doi:10.1016/j.msea.2020.140648

The publisher has not yet granted permission to display this abstract.
Imtiaz Ali Soomro , Srinivasa Rao Pedapati, Mokhtar Awang
Published: 28 January 2021
Materials Science and Engineering: A, Volume 803; doi:10.1016/j.msea.2020.140713

The publisher has not yet granted permission to display this abstract.
Byung Ju Lee, Jae Sook Song, Won Jin Moon, Sun Ig Hong
Published: 28 January 2021
Materials Science and Engineering: A, Volume 803; doi:10.1016/j.msea.2020.140684

The publisher has not yet granted permission to display this abstract.
Sang-Hwa Lee, Jae-Gil Jung , Sung-Il Baik , David N. Seidman , Min-Seok Kim, Young-Kook Lee, KwangJun Euh
Published: 28 January 2021
Materials Science and Engineering: A, Volume 803; doi:10.1016/j.msea.2020.140719

The publisher has not yet granted permission to display this abstract.
Xiaohao Sun , Minfang Chen, Debao Liu
Published: 28 January 2021
Materials Science and Engineering: A, Volume 803; doi:10.1016/j.msea.2020.140722

The publisher has not yet granted permission to display this abstract.
Mohammad Reza Roodgari, Roohollah Jamaati , Hamed Jamshidi Aval
Published: 28 January 2021
Materials Science and Engineering: A, Volume 803; doi:10.1016/j.msea.2020.140695

The publisher has not yet granted permission to display this abstract.
R. Catalano, E. Giardino, D. Treppiedi, F. Mangili, V. Morelli, F.M. Elli, A.L. Serban, M. Luconi, M. Mannelli, A. Spada, et al.
Published: 28 January 2021
Cancer Letters, Volume 497, pp 77-88; doi:10.1016/j.canlet.2020.10.022

The publisher has not yet granted permission to display this abstract.
Junjie Li, Junchao Xue, Min Ling, Jing Sun, Tian Xiao, Xiangyu Dai, Qian Sun, Cheng Cheng, Haibo Xia, Yongyue Wei, et al.
Published: 28 January 2021
Cancer Letters, Volume 497, pp 137-153; doi:10.1016/j.canlet.2020.10.023

The publisher has not yet granted permission to display this abstract.
Wenxia Si, Bisheng Zhou, Wen Xie, Hui Li, Ke Li, Sisi Li, Wenbing Deng, Pengcheng Shi, Chao Yuan, Tie Ke, et al.
Published: 28 January 2021
Cancer Letters, Volume 497, pp 28-40; doi:10.1016/j.canlet.2020.10.014

The publisher has not yet granted permission to display this abstract.
Yan Li, Ying Chen, Liyun Miao, Yongsheng Wang, Min Yu, Xin Yan, Qi Zhao, Hourong Cai, Yonglong Xiao, Guichun Huang
Published: 28 January 2021
Cancer Letters, Volume 497, pp 212-220; doi:10.1016/j.canlet.2020.10.032

The publisher has not yet granted permission to display this abstract.
Mimi Xu, Liqiang Zhou , Lei Zheng, Kai Liu, Yuhang Mao, Shasha Song
Published: 28 January 2021
Cancer Letters, Volume 497, pp 229-242; doi:10.1016/j.canlet.2020.10.037

The publisher has not yet granted permission to display this abstract.
Taras Hutak, Taras Krokhmalskii, Onofre Rojas, Sergio Martins De Souza, Oleg Derzhko
Published: 28 January 2021
Physics Letters A, Volume 387; doi:10.1016/j.physleta.2020.127020

The publisher has not yet granted permission to display this abstract.
M.R. Setare, Kh. Ghasemian, D. Jahani
Published: 28 January 2021
Physics Letters A, Volume 387; doi:10.1016/j.physleta.2020.127004

The publisher has not yet granted permission to display this abstract.
Yu.M. Shukrinov, A.S. Abouhaswa, A.E. Botha
Published: 28 January 2021
Physics Letters A, Volume 387; doi:10.1016/j.physleta.2020.127025

The publisher has not yet granted permission to display this abstract.
Zijian Zhou, Zhenya Yan
Published: 28 January 2021
Physics Letters A, Volume 387; doi:10.1016/j.physleta.2020.127010

The publisher has not yet granted permission to display this abstract.
Page of 354,668
Articles per Page
by
Show export options
  Select all
Back to Top Top