Insight into chemistry conceptual foundations shows that a powerful, autonomous chemical methodology exists which is based on visualization and association of chemical "building blocks". Such methodology has been expanded by the use of incommensurable theories resulting from the interplay of quantum mechanics and heuristic chemical concepts, resulting in models of great utility as predictive tools in guiding the creation of new and useful substances. Understanding such historical development has real benefits to chemistry practitioners, be they researchers, analysts or chemical educators.