Long-Term Exposure to Ambient PM2.5 and Increased Risk of CKD Prevalence in China
- 16 December 2020
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in Journal of the American Society of Nephrology
- Vol. 32 (2), 448-458
- https://doi.org/10.1681/ASN.2020040517
Abstract
Background Fine particulate matter (PM2.5) is an important environmental risk factor for cardiopulmonary diseases. However, the association between PM2.5 and risk of CKD remains under-recognized, especially in regions with high levels of PM2.5, such as China. Methods To explore the association between long-term exposure to ambient PM2.5 and CKD prevalence in China, we used data from the China National Survey of CKD, which included a representative sample of 47,204 adults. We estimated annual exposure to PM2.5 before the survey date at each participant's address, using a validated, satellite-based, spatiotemporal model with a 10 km x 10 km resolution. Participants with eGFR 65 years, and in participants without comorbid diseases compared with those with comorbidities. Conclusions These findings regarding the relationship between long-term exposure to high ambient PM2.5 levels and CKD in the general Chinese population provide important evidence for policymakers and public health practices to reduce the CKD risk posed by this pollutant.Funding Information
- National Natural Science Foundation of China (91846101, 81771938, 81301296, 81502780, 81900665)
- Beijing Nova Programme Interdisciplinary Cooperation Project (Z191100001119008)
- Ministry of Science and Technology of the People’s Republic of China (2016YFC1305400, 2017YFC0211600, 2019YFC2005000)
- Chinese Academy of Medical Sciences (2019RU023, 2019-I2M-5-046)
- Peking University (BMU20160466, BMU2018JI012, BMU2019JI005, Baidu Fund 2019BD017, BMU2018MX020, PKU2017LCX05, PKU2019LCXQ008)
This publication has 48 references indexed in Scilit:
- Prevalence of chronic kidney disease in China: a cross-sectional surveyThe Lancet, 2012
- Proteinuria: detection and role in native renal disease progressionTransplantation Reviews, 2012
- Lower estimated GFR and higher albuminuria are associated with adverse kidney outcomes. A collaborative meta-analysis of general and high-risk population cohortsKidney International, 2011
- Endothelial Dysfunction and Subsequent Decline in Glomerular Filtration Rate in Hypertensive PatientsCirculation, 2010
- Cardiac oxidative stress and dysfunction by fine concentrated ambient particles (CAPs) are mediated by angiotensin-IIInhalation Toxicology, 2010
- Coarse Particulate Matter Air Pollution and Hospital Admissions for Cardiovascular and Respiratory Diseases Among Medicare PatientsJAMA, 2008
- Airborne particulate matter exposure and urinary albumin excretion: the Multi-Ethnic Study of AtherosclerosisOccupational and Environmental Medicine, 2007
- Long-Term Exposure to Air Pollution and Incidence of Cardiovascular Events in WomenThe New England Journal of Medicine, 2007
- Modified Glomerular Filtration Rate Estimating Equation for Chinese Patients with Chronic Kidney DiseaseJournal of the American Society of Nephrology, 2006
- Estimating the Exposure–Response Relationships between Particulate Matter and Mortality within the APHEA Multicity ProjectEnvironmental Health Perspectives, 2005