Association between carotenoids and prostate cancer risk: A Meta-Analysis
Open Access
- 17 February 2019
- journal article
- review article
- Published by The North African Journal of Food and Nutrition Research (NAJFNR) in The North African Journal of Food and Nutrition Research
Abstract
Background: Carotenoids have been hypothesized to promote the prevention and treatment of prostate cancer (PC). Aims: Conducting a meta-analysis to assess whether the association differs by the type of carotenoids and to compare the relationships of each type of carotenoid with PC risk. Methods and Material: A literature search was conducted using the PubMed database. Pertinent studies were included in the meta-analysis of higher versus lower categories of dietary intakes or serum concentrations of carotenoids in relation to PC. A random-effects model was used to obtain the pooled odds ratios (ORs) and their confidence intervals (95%) of the case-control and cohort studies, for generic inverse variance data. Results: 13 identified studies involved 44,861 participants. The meta-analysis determined, for total carotenoids and lycopene, a statistically significant relationship with PC risk; OR: 0.88; 95% CI 0.81-0.96 and 0.87; 95% CI 0.77-0.99 respectively. However, no other carotenoid was noticed to have a statistically significant association with PC risk. Comparison of the effect of each type of carotenoid on PC risk showed that lycopene, lutein-zeaxanthin, and β-cryptoxanthin had a moderate inverse but not statistically significant relationship with PC risk. Compared to β-carotene, and α-carotene results, their effect estimates were higher than the previous carotenoids. Conclusions: Our findings indicate that PC was inversely associated with total carotenoids and lycopene dietary intake and serum concentrations. These data provide support for the utilization of carotenoids for the treatment and prevention of PC. Keywords: Sodium chloride, bread, salt reduction, Moroccan population.Keywords
This publication has 35 references indexed in Scilit:
- Tomato-based food products for prostate cancer prevention: what have we learned?Cancer and Metastasis Reviews, 2010
- Serum levels of folate, lycopene, β-carotene, retinol and vitamin E and prostate cancer riskEuropean Journal of Clinical Nutrition, 2010
- Association of selenium, tocopherols, carotenoids, retinol, and 15-isoprostane F2t in serum or urine with prostate cancer risk: the multiethnic cohortCancer Causes & Control, 2009
- Preparing a Cochrane ReviewPublished by Wiley ,2008
- Do dietary lycopene and other carotenoids protect against prostate cancer?International Journal of Cancer, 2004
- Retinol, carotenoids and the risk of prostate cancer: A case-control study from ItalyInternational Journal of Cancer, 2004
- The Antioxidant and Biological Properties of the CarotenoidsaAnnals of the New York Academy of Sciences, 1998
- A prospective study of consumption of carotenoids in fruits and vegetables and decreased cardiovascular mortality in the elderlyAnnals of Epidemiology, 1995
- Fruit, vegetables, and cancer prevention: A review of the epidemiological evidenceNutrition and Cancer, 1992
- Micronutrients and Cancer PreventionThe New England Journal of Medicine, 1986