This research is a response to topical objectives of studying adjustment abilities of human psyche in the situations of global uncertainty and potential threat to human life. The research is aimed at the insight into the ways of coping with lockdown during COVID-19 pandemic. The goal was achieved within the positive approach employed to find psychological resources that encourage successful and subjectively satisfactory solution to a difficult life situation. The research is based on the author’s psychological questionnaire with the use of quantitative scale of subjective assessment. The questionnaire helped gather information about the influence of lockdown on the psychological well-being and about the changes in human character and behavior. The study involved 306 people (246 women and 60 men) aged 18 to 67. The authors revealed that satisfaction with one’s well-being during lockdown positively correlates with the ability to see positive aspects of a situation, with learning new methods of self-regulation, with new interests, with encouraging one’s own creativity and sense of humor, with willingness to enjoy opportunity to finish things that were once postponed, with aspiration to understand oneself and other people and to experience the sense of unity with the whole world.