Viral Respiratory Infections in Hematological Patients
Open Access
- 7 July 2020
- journal article
- review article
- Published by Springer Science and Business Media LLC in Infectious Diseases and Therapy
- Vol. 9 (3), 495-510
- https://doi.org/10.1007/s40121-020-00313-6
Abstract
Viral infections of the respiratory system represent one of the most important complications in hematological patients in terms of both the severity of the clinical picture and its related impact on the duration of hospitalization, and of mortality. The most implicated viruses are those that commonly cause community-based respiratory diseases: respiratory syncytial virus, Influenza virus and rhinovirus. However, in some cases the clinical picture may be triggered by first infection with or reactivation of pathogens normally not responsible for clinically relevant diseases in immunocompetent subjects. This issue is currently being taken into greater consideration within the scientific community. However, the strong heterogeneity in the epidemiology and clinical expression of these infections and the lack of adequate therapeutic options imply that there is currently no uniform consensus on the best management of these patients. The main purpose of this review is to highlight which viruses are currently most implicated in the onset of these infections, what is their incidence in so heterogeneous and fragile patients and the factors that lead to disease's onset and evolution. Possible or available clinical management options, diagnostic and therapeutic tools, and preventive and prophylaxis measures are also discussed.This publication has 55 references indexed in Scilit:
- Traumatic Lumbar Punctures in Infants Hospitalized in the Neonatal Intensive Care UnitThe Pediatric Infectious Disease Journal, 2013
- Pathogenesis of rhinovirus infectionCurrent Opinion in Virology, 2012
- Parainfluenza Virus Infections in Children With Hematologic MalignanciesThe Pediatric Infectious Disease Journal, 2011
- Changing epidemiology of respiratory viral infections in hematopoietic cell transplant recipients and solid organ transplant recipientsCurrent Opinion in Infectious Diseases, 2011
- Differences in clinical outcomes after 2009 influenza A/H1N1 and seasonal influenza among hematopoietic cell transplant recipientsBlood, 2011
- Human rhinovirus and coronavirus detection among allogeneic hematopoietic stem cell transplantation recipientsBlood, 2010
- Guidelines for Preventing Infectious Complications among Hematopoietic Cell Transplantation Recipients: A Global PerspectiveTransplantation and Cellular Therapy, 2009
- The challenge of respiratory virus infections in hematopoietic cell transplant recipientsBritish Journal of Haematology, 2008
- Common community respiratory viruses in patients with cancerCancer, 2003
- Hospital Infection Control in Hematopoietic Stem Cell Transplant RecipientsEmerging Infectious Diseases, 2001