Sıçanlarda APAP Kaynaklı Toksisitede EKG, Oksidatif Stres ve Anjiyogenezin Belirlenmesi

Abstract

This study was aimed to evaluate the effects of N-acetyl-p-aminophenol (APAP) toxicity on the cardiovascular system as there exist relatively a few studies on this matter. The study included 14 female Wistar rats divided into two groups having 7 rats in each (control-APAP). Control group received no medication and APAP group was given single oral dose of 1g/kg APAP. ECG measurements of each animal in either group were obtained before the administration of APAP (0 h) and at the 1st, 6th, 12th and 24th h after the APAP administration. All animals were sacrificed at the end of the study. Heart tissue samples were obtained for biochemical and histopathological analyses. The levels of MDA, GSH, Apelin, Elabela, Meteorin, Endoglin, Keap1, and Nrf2 were measured in the tissue samples. Results revealed a statistically significantly prolonged QTc and QRS intervals and increased heart in the APAP group. A notable increase in MDA and Endoglin, and a significant decrease in GSH, Elabela, and Nrf2 levels occurred in the APAP group. Histopathologically, necrotic lesions were found in the APAP group. The use of high doses of APAP as an analgesic may cause permanent damage in the cardiovascular system.