Elevated cadmium and 8-hydroxy-2’-deoxyguanosine (8-OHdG) levels in residents living near electroplating industries
- 2 March 2021
- journal article
- research article
- Published by Springer Science and Business Media LLC in Environmental Science and Pollution Research
- Vol. 28 (26), 34427-34435
- https://doi.org/10.1007/s11356-021-13209-w
Abstract
This study aims to evaluate the body burdens of cadmium (Cd) associated with potential health impairment in residents living near electroplating industries. A total of 269 residents from exposure area and 106 from control area were recruited. We measured the blood and urinary Cd levels using an inductively coupled plasma mass spectrometer (ICP-MS); performed physical examinations; determined the urinary levels of β2-microglobulin (β2-MG), Nacetyl-β-D-glucosaminidase (NAG), and 8-hydroxy-2’-deoxyguanosine (8-OHdG); and evaluated the associations between Cd and these biomarkers. Blood and urinary Cd levels in exposure group were statistically higher than in control group (1.712 vs. 1.159 μg/L; 1.980 vs. 1.740 μg/L, respectively, p < 0.05). Urinary β2-MG and 8-OHdG levels in exposure group were also statistically higher (0.448 vs. 0.090 mg/L; 12.759 vs. 12.115 μg/L, respectively, p < 0.05), but urinary NAG levels showed no significant difference between the two groups (13.614 vs. 8.246 IU/L, p > 0.05). The proportion of abnormal nasal symptoms occurring in exposed subjects (88.8%) was much higher than in control subjects (78.2%, p < 0.05). Urinary Cd levels were positively correlated with blood Cd levels, urinary 8-OHdG, and NAG levels (r = 0.307, r = 0.185, r = 0.150, p < 0.05), but not correlated with urinary β2-MG levels (p > 0.05). In conclusion, our study revealed that residents living in close proximity to electroplating industries had elevated body burdens of Cd levels, as well as slight renal dysfunction and DNA oxidation damage.This publication has 25 references indexed in Scilit:
- Oxidative DNA damage and global DNA hypomethylation are related to folate deficiency in chromate manufacturing workersJournal of Hazardous Materials, 2012
- Renal Function after Reduction in Cadmium Exposure: An 8-Year Follow-up of Residents in Cadmium-Polluted AreasEnvironmental Health Perspectives, 2012
- In vivo visualization of olfactory pathophysiology induced by intranasal cadmium instillation in miceNeuroToxicology, 2011
- Chronic occupational exposure to hexavalent chromium causes DNA damage in electroplating workersBMC Public Health, 2011
- Reassessment of the threshold of urinary cadmium by using hybrid approach in a cadmium non-polluted area in JapanInternational Journal of Hygiene and Environmental Health, 2011
- Exposure to metal mixtures and human health impacts in a contaminated area in Nanning, ChinaEnvironment International, 2005
- Biomonitoring of chromium for residents of areas with a high density of electroplating factoriesJournal of Exposure Science & Environmental Epidemiology, 2005
- Olfactory Function in Workers Exposed to Moderate Airborne Cadmium LevelsNeuroToxicology, 2003
- Chromium (VI) induced oxidative damage to DNA: increase of urinary 8-hydroxydeoxyguanosine concentrations (8-OHdG) among electroplating workersOccupational and Environmental Medicine, 2003