Quantitative Surface-Enhanced Raman Spectroscopy for Field Detections Based on Structurally Homogeneous Silver-Coated Silicon Nanocone Arrays
Open Access
- 12 July 2021
- journal article
- research article
- Published by American Chemical Society (ACS) in ACS Omega
- Vol. 6 (29), 18928-18938
- https://doi.org/10.1021/acsomega.1c02179
Abstract
Practical application of surface-enhanced Raman spectroscopy (SERS) is greatly limited by the inaccurate quantitative analyses due to the measuring parameter’s fluctuations induced by different operators, different Raman spectrometers, and different test sites and moments, especially during the field tests. Herein, we develop a strategy of quantitative SERS for field detection via designing structurally homogeneous and ordered Ag-coated Si nanocone arrays. Such an array is fabricated as SERS chips by depositing Ag on the template etching-induced Si nanocone array. Taking 4-aminothiophenol as the typical analyte, the influences of fluctuations in measuring parameters (such as defocusing depth and laser powers) on Raman signals are systematically studied, which significantly change SERS measurements. It has been shown that the silicon underneath the Ag coating in the chip can respond to the measuring parameters’ fluctuations synchronously with and similar to the analyte adsorbed on the chip surface, and the normalization with Si Raman signals can well eliminate the big fluctuations (up to 1 or 2 orders of magnitude) in measurements, achieving highly reproducible measurements (mostly, <5% in signal fluctuations) and accurate quantitative SERS analyses. Finally, the simulated field tests demonstrate that the developed strategy enables quantitatively analyzing the highly scattered SERS measurements well with 1 order of magnitude in signal fluctuation, exhibiting good practicability. This study provides a new practical chip and reliable quantitative SERS for the field detection of real samples.Funding Information
- Ministry of Science and Technology of the People's Republic of China (2017YFA0207101)
- CAS-SAFEA International Partnership Program for Creative Research Teams
- National Natural Science Foundation of China (11974352, 51771182, 52001305)
This publication has 62 references indexed in Scilit:
- Fundamental understanding and applications of plasmon-enhanced Raman spectroscopyNature Reviews Physics, 2020
- Surface enhanced Raman scattering artificial nose for high dimensionality fingerprintingNature Communications, 2020
- C−H Arylation on Nickel Nanoparticles Monitored by In Situ Surface‐Enhanced Raman SpectroscopyAngewandte Chemie, 2019
- Is the Suzuki–Miyaura Cross-Coupling Reaction in the Presence of Pd Nanoparticles Heterogeneously or Homogeneously Catalyzed? An Interfacial Surface-Enhanced Raman Spectroscopy StudyThe Journal of Physical Chemistry Letters, 2019
- Designing surface-enhanced Raman scattering (SERS) platforms beyond hotspot engineering: emerging opportunities in analyte manipulations and hybrid materialsChemical Society Reviews, 2018
- Vibrational Properties of a Monolayer Silicene Sheet Studied by Tip-Enhanced Raman SpectroscopyPhysical Review Letters, 2017
- SERS-Activated Platforms for Immunoassay: Probes, Encoding Methods, and ApplicationsChemical Reviews, 2017
- Nanostructure-based plasmon-enhanced Raman spectroscopy for surface analysis of materialsNature Reviews Materials, 2016
- Dielectric shell isolated and graphene shell isolated nanoparticle enhanced Raman spectroscopies and their applicationsChemical Society Reviews, 2015
- Highly Sensitive, Uniform, and Reproducible Surface‐Enhanced Raman Spectroscopy from Hollow Au‐Ag Alloy NanourchinsAdvanced Materials, 2014