Schwann cell interactions during the development of the peripheral nervous system
- 12 April 2020
- journal article
- review article
- Published by Wiley in Developmental Neurobiology
- Vol. 81 (5), 464-489
- https://doi.org/10.1002/dneu.22744
Abstract
Schwann cells play a critical role in the development of the peripheral nervous system (PNS), establishing important relationships both with the extracellular milieu and other cell types, particularly neurons. In this review, we discuss various Schwann cell interactions integral to the proper establishment, spatial arrangement, and function of the PNS. We include signals that cascade onto Schwann cells from axons and from the extracellular matrix, bidirectional signals that help to establish the axo‐glial relationship and how Schwann cells in turn support the axon. Further, we speculate on how Schwann cell interactions with other components of the developing PNS ultimately promote the complete construction of the peripheral nerve.Keywords
Funding Information
- National Institute of Neurological Disorders and Stroke
- Eunice Kennedy Shriver National Institute of Child Health and Human Development
- National Multiple Sclerosis Society
- U.S. Department of Defense
- Empire State Development Corporation
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