Neurovascular coupling alterations in type 2 diabetes: a 5-year longitudinal MRI study
Open Access
- 18 January 2021
- journal article
- research article
- Published by BMJ in BMJ Open Diabetes Research & Care
- Vol. 9 (1), e001433
- https://doi.org/10.1136/bmjdrc-2020-001433
Abstract
Introduction Respective alterations in resting-state brain neural activity and cerebral blood flow (CBF) in type 2 diabetes mellitus (T2DM) have been reported. However, their coupling alteration in T2DM remains largely unknown. Research design and methods Twenty-seven patients with T2DM aged 40–67 years and 36 well-matched healthy controls (HCs) underwent resting-state functional MRI (rs-fMRI) and arterial spin labeling (ASL) scans at two time points with a 5-year interval. Regional homogeneity (ReHo) and CBF were calculated from rs-fMRI and ASL, respectively. The standardized ReHo:CBF ratio (mReHo:mCBF ratio), the spontaneous neuronal activity per unit CBF supply, was compared between the two time points. Relationships between the mReHo:mCBF ratio and memory performance were analyzed. Results Over 5 years, decreased mReHo:mCBF ratios in patients with T2DM were mainly distributed in four regions, among which the left insula exhibited more severely decreased mReHo:mCBF ratio in patients with T2DM than in HCs, while the left postcentral gyrus, the right Rolandic operculum, and the right precentral gyrus showed no significant intergroup difference. Correlations between the mReHo:mCBF ratio and memory performance were also found in patients with T2DM. Conclusions This study suggests that T2DM may accelerate neurovascular coupling impairment in specific brain regions (the left insula), contributing to memory decline. This study implies that the mReHo:mCBF ratio is a potential imaging marker for detecting neurovascular changes.Keywords
This publication has 51 references indexed in Scilit:
- Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disordersNature Reviews Neuroscience, 2011
- Glial and neuronal control of brain blood flowNature, 2010
- Pericytes Control Key Neurovascular Functions and Neuronal Phenotype in the Adult Brain and during Brain AgingNeuron, 2010
- Neurometabolic Coupling in the Lateral Geniculate Nucleus Changes With Extended AgeJournal of Neurophysiology, 2010
- Reliability and precision of pseudo‐continuous arterial spin labeling perfusion MRI on 3.0 T and comparison with 15O‐water PET in elderly subjects at risk for Alzheimer's diseaseNMR in Biomedicine, 2010
- DPARSF: a MATLAB toolbox for “pipeline” data analysis of resting-state fMRIFrontiers in Systems Neuroscience, 2010
- Diagnosis and Classification of Diabetes MellitusDiabetes Care, 2010
- Cerebral perfusion in relation to cognitive function and type 2 diabetesDiabetologia, 2008
- A fast diffeomorphic image registration algorithmNeuroImage, 2007
- A Rating Instrument For Anxiety DisordersPsychosomatics, 1971