The interplay between emerging human coronavirus infections and autophagy
Open Access
- 1 January 2021
- journal article
- review article
- Published by Taylor & Francis Ltd in Emerging Microbes & Infections
- Vol. 10 (1), 196-205
- https://doi.org/10.1080/22221751.2021.1872353
Abstract
Following outbreaks of severe acute respiratory syndrome coronavirus (SARS-CoV) and the Middle East respiratory syndrome coronavirus (MERS-CoV) in 2002 and 2012, respectively, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the third highly pathogenic emerging human coronavirus (hCoV). SARS-CoV-2 is currently causing the global coronavirus disease 2019 (COVID-19) pandemic. CoV infections in target cells may stimulate the formation of numerous double-membrane autophagosomes and induce autophagy. Several studies provided evidence that hCoV infections are closely related to various cellular aspects associated with autophagy. Autophagy may even promote hCoV infection and replication. However, so far it is unclear how hCoV infections induce autophagy and whether the autophagic machinery is necessary for viral propagation. Here, we summarize the most recent advances concerning the mutual interplay between the autophagic machinery and the three emerging hCoVs, SARS-CoV, MERS-CoV, and SARS-CoV-2 and the model system mouse hepatitis virus. We also discuss the applicability of approved and well-tolerated drugs targeting autophagy as potential treatment against COVID-19.Funding Information
- National Natural Science Foundation of China (82002131)
- Natural Science Foundation Project of CQ CSTC (cstc2020jcyj-msxmX0081)
- Venture & Innovation Support Programme for Chongqing Overseas Returnees (cx2019114)
- COVID-19 Emergency Project (CQMUNCP0207)
- Scientific Research Staring Foundation of Chongqing Medical University (X9729)
- Chongqing Medical University
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