The Therapeutic Strategies Targeting Mitochondrial Metabolism in Cardiovascular Disease
Open Access
- 9 December 2022
- journal article
- review article
- Published by MDPI AG in Pharmaceutics
- Vol. 14 (12), 2760
- https://doi.org/10.3390/pharmaceutics14122760
Abstract
Cardiovascular disease (CVD) is a group of systemic disorders threatening human health with complex pathogenesis, among which mitochondrial energy metabolism reprogramming has a critical role. Mitochondria are cell organelles that fuel the energy essential for biochemical reactions and maintain normal physiological functions of the body. Mitochondrial metabolic disorders are extensively involved in the progression of CVD, especially for energy-demanding organs such as the heart. Therefore, elucidating the role of mitochondrial metabolism in the progression of CVD is of great significance to further understand the pathogenesis of CVD and explore preventive and therapeutic methods. In this review, we discuss the major factors of mitochondrial metabolism and their potential roles in the prevention and treatment of CVD. The current application of mitochondria-targeted therapeutic agents in the treatment of CVD and advances in mitochondria-targeted gene therapy technologies are also overviewed.Funding Information
- National Natural Science Foundation of China (31571172, 81870343, X.T.)
- Chongqing Natural Science Foundation (cstc2021jcyj-msxmX0043, X.T.)
- Hunan Provincial Natural Science Foundation of China (2020JJ5398)
- Scientific Research Fund of Hunan Provincial Education Department (20B416)
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