Saponin-rich extracts reverse obesity and offer protection against obesity-induced inflammation in high-fat diet mice
Open Access
- 25 January 2021
- journal article
- Published by AOSIS in Journal of Medicinal Plants for Economic Development
- Vol. 5 (1), 9
- https://doi.org/10.4102/jomped.v5i1.101
Abstract
Background: Obesity is a medical condition that occurs as a result of excess body fat which increases the risk of several metabolic disorders. Non-availability of efficient classical treatment for obesity has led to propose alternative treatment using plant material. Aim: To investigated the effect of saponin-rich extract of Lindackeria dentata (SLD) on obesity and some specific genes involved in inflammation and insulin resistance in the high-fat diet (HFD) on mice. Setting: The plant leaves were collected from farmland in Igede Ekiti, South-western Nigeria and authenticated at a herbarium unit of the Department of Plant Science and Biotechnology, Ekiti State University, Ado Ekiti, Nigeria. Methods: Saponin-rich extracts from Lindackeria dentata leaves were extracted using standard procedures, HFD was given to some selected mice for 12 weeks whilst monitoring blood glucose and body weight (bw) of the mice. Obese mice were treated orally with SLD 25 mg/kg, 50 mg/kg, 100 mg/kg and 200 mg/kg bw for 3 weeks, sacrificed, organs were collected and some biochemical assays were performed. Expression of some genes and histopathological study of the pancreas were also carried out using a standard scientific protocol. Results: Saponin-rich extract of Lindackeria dentata treatment significantly reduced (p < 0.05) bw and adipose fat deposit, and caused partial restoration of pancreatic islet expansion (100 mg/kg and 200 mg/kg) coupled with accentuated regulation of leptin, insulin and IL-10 gene (25 mg/kg, 50 mg/kg and 100 mg/kg) when compared with control groups. Conclusion: The present data clearly showed that SLD could be a good intervention in the treatment of obesity and its attendant metabolic disorders.Keywords
This publication has 30 references indexed in Scilit:
- Anti-hyperglycaemic and lipid lowering potential of Adenanthera pavonina Linn. in streptozotocin induced diabetic ratsAdvances in Traditional Medicine, 2012
- Immunity as a link between obesity and insulin resistanceMolecular Aspects of Medicine, 2012
- Saponins from the traditional medicinal plant Momordica charantia stimulate insulin secretion in vitroPhytomedicine, 2011
- Anti-obesity effects of the methanolic extract and chakasaponins from the flower buds of Camellia sinensis in miceBioorganic & Medicinal Chemistry, 2011
- Body mass index, waist circumference and waist–hip ratio: which is the better discriminator of cardiovascular disease mortality risk? Evidence from an individual‐participant meta‐analysis of 82 864 participants from nine cohort studiesObesity Reviews, 2011
- A highly saturated fat-rich diet is more obesogenic than diets with lower saturated fat contentNutrition Research, 2010
- Anti-diabetic effects of Panax notoginseng saponins and its major anti-hyperglycemic componentsJournal of Ethnopharmacology, 2010
- Hypoglycaemic activity of saponin fraction extracted fromMomordica charantiain PEG/salt aqueous two-phase systemsNatural Product Research, 2008
- Antiobese and hypolipidemic effects of platycodin saponins in diet-induced obese rats: evidences for lipase inhibition and calorie intake restrictionInternational Journal of Obesity, 2005
- Cyclopentanoid Cyanohydrin Glucosides and Amides ofLindackeria dentataPlanta Medica, 2004