Predictors of Weight Loss in Patients With Head and Neck Cancer Receiving Radiation or Concurrent Chemoradiation Treated at a Tertiary Cancer Center
- 24 April 2020
- journal article
- research article
- Published by Wiley in Nutrition in Clinical Practice
- Vol. 35 (6), 1047-1052
- https://doi.org/10.1002/ncp.10488
Abstract
Background Radiation therapy (RT) has remained the mainstay treatment approach for head and neck cancers. Weight loss due to tumor or tumor-related factors remains a major health issue among head and neck cancer patients. Methods A total of 357 patients were identified for the study. Possible weight-loss predictors were determined in the patients undergoing RT based on the patient demographics, tumor site, and treatment characteristics. Results The mean age of patients was 52 years, whereas the median age was 51 years (range, 18–87). Two hundred and thirteen (66%) patients had oral cavity cancers, 43 (14%) had oropharyngeal cancer, 26 (8%) had hypopharyngeal cancer, 13 (6%) had larynx cancer, and 19 (6%) had other site involvement. A total of 192 patients received 3-dimensional conformal radiation therapy (3DCRT), whereas 127 patients received intensity modulated radiation therapy–image guided radiation therapy (IMRT-IGRT), 212 (66%) received concurrent chemotherapy, and 107 (34%) patients did not receive concurrent chemotherapy. A total of 127 (40%) of the patients gained weight during the first week of RT; on the other hand, maximum weight loss among patients was occurred during the third and fourth weeks of RT. Conclusion Analysis by logistic regression determined there is significant weight loss (>10%) in patients receiving radical RT as compared with adjuvant RT. Better outcomes were observed in patients receiving RT by IMRT-IGRT technique as compared with 3DCRT technique.Keywords
This publication has 32 references indexed in Scilit:
- Pretreatment dietary patterns, weight status, and head and neck squamous cell carcinoma prognosisThe American Journal of Clinical Nutrition, 2013
- Weight loss in patients with head and neck cancer during and after conventional and accelerated radiotherapyActa Oncologica, 2012
- Exercise and nutrition for head and neck cancer patients: a patient oriented, clinic-supported randomized controlled trialBMC Cancer, 2012
- Validated swallowing and nutrition guidelines for patients with head and neck cancer: Identification of high‐risk patients for proactive gastrostomyHead & Neck, 2012
- Parotid-sparing intensity modulated versus conventional radiotherapy in head and neck cancer (PARSPORT): a phase 3 multicentre randomised controlled trialThe Lancet Oncology, 2011
- The relationship between weight loss and health-related quality of life in persons treated for head and neck cancerSupportive Care in Cancer, 2010
- A descriptive review of the factors contributing to nutritional compromise in patients with head and neck cancerSupportive Care in Cancer, 2009
- Predictors of Non-Compliance With Radiotherapy Among Patients With Squamous Cell Carcinoma of the Head and Neck Treated at a Veterans Affairs HospitalInternational Journal of Radiation Oncology*Biology*Physics, 2007
- ESPEN Guidelines for Nutrition Screening 2002Clinical Nutrition, 2003
- Oral Sequelae of Head and Neck RadiotherapyCritical Reviews in Oral Biology & Medicine, 2003