Ribosome traffic jam in neurodegeneration: decoding hurdles in Huntington disease – The symptoms of HD, a neurodegenerative disorder, are severe disruption of cognitive and motor functions, including changes in posture and gait. HTT, the gene responsible for HD, is CAG (codes for glutamine (Q)) expanded and encodes a 350-kd protein (Figure 1) that has a role in neuronal survival, vesicular trafficking, and transcription, as well as (...)