Cellular Functions of Small Heat Shock Proteins (HSPB) in Hepatocellular Carcinoma
- 1 December 2021
- journal article
- review article
- Published by Bentham Science Publishers Ltd. in Current Molecular Medicine
- Vol. 21 (10), 872-887
- https://doi.org/10.2174/1573405617666210204211252
Abstract
Heat shock proteins (HSPs) play an essential role as molecular chaperones in proteostasis. Small HSPs are a group of low-molecular-weight HSPs in the range of 12-43 kDa and are classified as HSPB. Within the ten members of the family, HSPB1 (HSP27), HSPB5 (B-crystallin), HSPB6 (HSP20), and HSPB8 (HSP22) ubiquitously exist in various tissues, including liver tissue. These small HSPs undergo phosphorylation as a post-translational modification, and their functions are modulated. Hepatocellular carcinoma (HCC) is one of the most frequent cancers and the fourth leading cause of cancer-related death worldwide. HSPs play a cytoprotective role as molecular chaperones. Thus, HSPB has been generally considered to protect HCC cells and help the progression of HCC. On the other hand, recent studies from our laboratories have demonstrated suppressive roles of phospho-HSPB1, HSPB6, and HSPB8 in progression of HCC. These findings may provide a basis for a novel defense system by HSPB against HCC progression. This review focuses on the cellular functions of HSPB in HCC and summarizes the current research.Keywords
This publication has 83 references indexed in Scilit:
- Direct Association of Heat Shock Protein 20 (HSPB6) with Phosphoinositide 3-kinase (PI3K) in Human Hepatocellular Carcinoma: Regulation of the PI3K ActivityPLOS ONE, 2013
- Sequence, Structure, and Dynamic Determinants of Hsp27 (HspB1) Equilibrium Dissociation Are Encoded by the N-Terminal DomainBiochemistry, 2012
- The PARP Side of the Nucleus: Molecular Actions, Physiological Outcomes, and Clinical TargetsMolecular Cell, 2010
- Phosphorylation Dependence of Hsp27 Multimeric Size and Molecular Chaperone FunctionOnline Journal of Public Health Informatics, 2009
- The role of heat shock proteins in gastrointestinal diseasesGut, 2009
- Regulation of HSP27 on NF-κB pathway activation may be involved in metastatic hepatocellular carcinoma cells apoptosisBMC Cancer, 2009
- Structure and Mechanism of Protein Stability Sensors: Chaperone Activity of Small Heat Shock ProteinsBiochemistry, 2009
- Proliferation of human HCC cells and chemically induced mouse liver cancers requires JNK1-dependent p21 downregulationJCI Insight, 2008
- The Levels of Ghrelin, Leptin, TNF-α, and IL-6 in Liver Cirrhosis and Hepatocellular Carcinoma due to HBV and HDV InfectionMediators of Inflammation, 2006
- The role of heat shock protein 27 expression in hepatocellular carcinoma in Japan: special reference to the difference between hepatitis B and CLiver International, 2004