Prenatal di-(2-ethylhexyl) phthalate maternal exposure impairs the spatial memory of adult mouse offspring in a phase- and gender-dependent manner
- 15 May 2020
- journal article
- research article
- Published by Springer Science and Business Media LLC in Environmental Science and Pollution Research
- Vol. 27 (22), 28267-28275
- https://doi.org/10.1007/s11356-020-09181-6
Abstract
DEHP is a wildly used plasticizer. Maternal DEHP exposure induced fetal growth restriction (FGR) and behavioral abnormalities in adolescence and adulthood mouse. The effect of low birth weight induced by DEHP on behaviors after growing up is not certain. In this study, the ICR pregnant mice were exposed to 200 mg/kg DEHP during gestation 6–12 days or 13–17 days, which can create FGR model. The F1 offspring were performed three ethological experiments at puberty (6 weeks postpartum) and adult period (8 weeks postpartum). The open field test was performed to detect the locomotor activity and anxiety, the elevated plus maze to test anxiety-like behavior, and the Morris water maze assay to measure the spatial learning and memory capability of male and female offspring. The results showed that spatial memory ability was dramatically impaired for male rather than female offspring in gestation 13–17 days’ group. Other behaviors had no statistically different between groups. These findings suggest that prenatal DEHP exposure disturbed mouse offspring spatial memory ability in a phase- and gender-dependent manner.Funding Information
- National Natural Science Foundation of China (81630084, 31000602, 81471467)
- Natural Science Foundation of Anhui Province (1608085MH218)
- Natural Science Foundation of Anhui Province (1308085QC48)
- Key Projects of Scientific Research Project of Colleges and Universities in Anhui Province (KJ2019A0281)
- Grants for Scientific Research of BSKY from Anhui Medical University (XJ201203)
This publication has 34 references indexed in Scilit:
- Di-(2-Ethylhexyl) Phthalate Exposure Is Negatively Correlated with Trait Anxiety in Girls but not with Trait Anxiety in Boys or Anxiety-Like Behavior in Male MiceJournal of Child Neurology, 2014
- Fetal Origins of Adult DiseaseCurrent Problems in Pediatric and Adolescent Health Care, 2011
- Morris Water Maze Test for Learning and Memory Deficits in Alzheimer's Disease Model MiceJournal of Visualized Experiments, 2011
- Perinatal exposure to di-(2-ethylhexyl) phthalate leads to restricted growth and delayed lung maturation in newborn ratsjpme, 2010
- Intrauterine growth restriction due to uteroplacental insufficiency decreased white matter and altered NMDAR subunit composition in juvenile rat hippocampiAmerican Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 2009
- A dose–response study following in utero and lactational exposure to di-(2-ethylhexyl)-phthalate (DEHP): Non-monotonic dose–response and low dose effects on rat brain aromatase activityToxicology, 2006
- Morris water maze: procedures for assessing spatial and related forms of learning and memoryNature Protocols, 2006
- Proposed Mode of Action for In Utero Effects of Some Phthalate Esters on the Developing Male Reproductive TractToxicologic Pathology, 2006
- Identification and Measurement of Plasticizer in Neonatal Tissues after Umbilical Catheters and Blood ProductsThe New England Journal of Medicine, 1975