Immunopathological Roles of Neutrophils in Virus Infection and COVID-19
- 28 January 2021
- journal article
- review article
- Published by Ovid Technologies (Wolters Kluwer Health) in Shock
- Vol. 56 (3), 345-351
- https://doi.org/10.1097/shk.0000000000001740
Abstract
COVID-19 caused by SARS-CoV-2 infection has been spread around the world and is currently affecting global public health. Clinical evidence indicates that the elevated number of peripheral neutrophils and higher ratio of neutrophils-to-lymphocytes are correlated with severe outcomes in COVID-19 patients, suggesting the possible immunopathological role of neutrophils during SARS-CoV-2 infection. As an abundant innate immune cell type, neutrophils are well known for their contributions to antimicrobial defense. However, their dysfunction is also associated with different inflammatory signatures during the pathogenesis of infection. Herein, in this mini-review, we summarize the recent progress on the potential role of neutrophils during COVID-19-associated inflammatory responses. In particular, we highlight the interactions between neutrophils and viruses as well as the relationship of neutrophils with cytokine storm and thrombosis in COVID-19 patients. Lastly, we discuss the importance of neutrophils as potential therapeutic targets for COVID-19.Keywords
This publication has 71 references indexed in Scilit:
- Neutrophil cell surface receptors and their intracellular signal transduction pathwaysInternational Immunopharmacology, 2013
- Human Respiratory Syncytial Virus Nucleoprotein and Inclusion Bodies Antagonize the Innate Immune Response Mediated by MDA5 and MAVSJournal of Virology, 2012
- Extracellular histones promote thrombin generation through platelet-dependent mechanisms: involvement of platelet TLR2 and TLR4Blood, 2011
- Excessive Neutrophils and Neutrophil Extracellular Traps Contribute to Acute Lung Injury of Influenza PneumonitisThe American Journal of Pathology, 2011
- Respiratory Syncytial Virus-Mediated NF-κB p65 Phosphorylation at Serine 536 Is Dependent on RIG-I, TRAF6, and IKKβJournal of Virology, 2010
- Regulatory molecules required for nucleotide‐sensing Toll‐like receptorsImmunological Reviews, 2008
- Toll-like receptor–mediated activation of neutrophils by influenza A virusBlood, 2008
- Neutrophil Elastase Is Needed for Neutrophil Emigration into Lungs in Ventilator-Induced Lung InjuryAmerican Journal of Respiratory Cell and Molecular Biology, 2008
- Phagocytosis of Apoptotic Neutrophils Regulates Granulopoiesis via IL-23 and IL-17Immunity, 2005
- Activation of vascular endothelial cells by IL-1α released by epithelial cells infected with respiratory syncytial virusCellular Immunology, 2003