The PKD-Dependent Biogenesis of TGN-to-Plasma Membrane Transport Carriers
Open Access
- 28 June 2021
- Vol. 10 (7), 1618
- https://doi.org/10.3390/cells10071618
Abstract
Membrane trafficking is essential for processing and transport of proteins and lipids and to establish cell compartmentation and tissue organization. Cells respond to their needs and control the quantity and quality of protein secretion accordingly. In this review, we focus on a particular membrane trafficking route from the trans-Golgi network (TGN) to the cell surface: protein kinase D (PKD)-dependent pathway for constitutive secretion mediated by carriers of the TGN to the cell surface (CARTS). Recent findings highlight the importance of lipid signaling by organelle membrane contact sites (MCSs) in this pathway. Finally, we discuss our current understanding of multiple signaling pathways for membrane trafficking regulation mediated by PKD, G protein-coupled receptors (GPCRs), growth factors, metabolites, and mechanosensors.Keywords
Funding Information
- Ministry of Education, Culture, Sports, Science, and Technology of Japan (20K06562, RYC-2017-22227, PID2019-106232RB-I00/10.13039/501100011033; Severo Ochoa CEX2019-000910-S)
This publication has 167 references indexed in Scilit:
- A new class of carriers that transport selective cargo from the trans Golgi network to the cell surfaceThe EMBO Journal, 2012
- Protein kinase D: coupling extracellular stimuli to the regulation of cell physiologyEMBO Reports, 2011
- ADF/Cofilin Regulates Secretory Cargo Sorting at the TGN via the Ca2+ ATPase SPCA1Developmental Cell, 2011
- Phospholipase D in the Golgi apparatusBiochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2009
- Protein kinase D1 regulates cofilin-mediated F-actin reorganization and cell motility through slingshotNature, 2009
- Regulation of PKD by the MAPK p38δ in Insulin Secretion and Glucose HomeostasisCell, 2009
- CtBP3/BARS drives membrane fission in dynamin-independent transport pathwaysNature, 2005
- The bipolar mitotic kinesin Eg5 moves on both microtubules that it crosslinksNature, 2005
- Protein kinase D regulates basolateral membrane protein exit from trans-Golgi networkNature, 2004
- Gβγ-Mediated Regulation of Golgi Organization Is through the Direct Activation of Protein Kinase DCell, 1999