Psychological impact of genetic and clinical screening for pulmonary fibrosis on asymptomatic first-degree relatives of affected individuals
- 22 January 2021
- Vol. 76 (6), 621-623
- https://doi.org/10.1136/thoraxjnl-2020-216244
Abstract
Screening for pulmonary fibrosis may help to identify early stages of the disease. We assessed the psychological impact of screening undiagnosed first-degree relatives of patients with pulmonary fibrosis by administering two validated measures after participants received their results: the Decisional Regret Scale and the Feelings About genomiC Testing Results Questionnaire. More than 90% of relatives reported either no or mild decisional regret. Increased measures of decisional regret and negative feelings were present in those found to have a low diffusion capacity of carbon monoxide or interstitial lung abnormalities. Results of telomere length and genetic testing did not significantly impact regret.Funding Information
- National Heart, Lung, and Blood Institute (R01 HL130974)
This publication has 8 references indexed in Scilit:
- Interstitial Lung Disease in Relatives of Patients with Pulmonary FibrosisAmerican Journal of Respiratory and Critical Care Medicine, 2020
- Interstitial Lung Disease in Relatives of Patients with Pulmonary FibrosisPublished by American Thoracic Society ,2020
- Clinical exome sequencing vs. usual care for hereditary colorectal cancer diagnosis: A pilot comparative effectiveness studyContemporary Clinical Trials, 2019
- The Feelings About genomiC Testing Results (FACToR) Questionnaire: Development and Preliminary ValidationJournal of Genetic Counseling, 2018
- Regret associated with the decision for breast reconstruction: The association of negative body image, distress and surgery characteristics with decision regretPsychology & Health, 2008
- Flow cytometry and FISH to measure the average length of telomeres (flow FISH)Nature Protocols, 2006
- Validation of a Decision Regret ScaleMedical Decision Making, 2003
- Idiopathic Pulmonary FibrosisThe New England Journal of Medicine, 2001