Transient blood thinning during extracorporeal blood purification via the inactivation of coagulation factors by hydrogel microspheres
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- 25 January 2021
- journal article
- research article
- Published by Springer Science and Business Media LLC in Nature Biomedical Engineering
- Vol. 5 (10), 1143-1156
- https://doi.org/10.1038/s41551-020-00673-x
Abstract
During extracorporeal blood purification, anticoagulants are administered to prevent thrombogenesis. However, haemorrhagic complications owing to near-complete inactivation of blood coagulation and delayed recovery of haemostasis pose serious risks to patients. Here, we show in vitro and in beagle dogs that hydrogel microspheres that adsorb the coagulation factors VIII, IX and XI provide transient blood thinning when placed in the extracorporeal circuit before blood purification. The microspheres inhibited the activities of the coagulation factors by levels (~8–30%) similar to those occurring in mild haemophilia. On its reintroduction into the animal, the purified pseudo-haemophilic blood favoured faster recovery of haemostasis. The transient blood-thinning strategy may increase the safety of clinical blood-purification procedures.Keywords
This publication has 52 references indexed in Scilit:
- Evolving importance of kidney disease: from subspecialty to global health burdenThe Lancet, 2013
- Modification of polyethersulfone membranes – A review of methodsProgress in Materials Science, 2013
- Thrombosis as an intravascular effector of innate immunityNature Reviews Immunology, 2012
- Guidelines for the management of hemophiliaHaemophilia, 2012
- What are the anticoagulation options for intermittent hemodialysis?Nature Reviews Nephrology, 2011
- Bleeding risk and the management of bleeding complications in patients undergoing anticoagulant therapy: focus on new anticoagulant agentsBlood, 2008
- Triggers, targets and treatments for thrombosisNature, 2008
- A wearable haemodialysis device for patients with end-stage renal failure: a pilot studyThe Lancet, 2007
- Heparin free dialysis: Comparative data and results in high risk patientsKidney International, 1987
- Heparin-like activity of insoluble sulphonated polystyrene resins: Part I: Influence of the surface density, nature and binding of substituted anionic groupsBiomaterials, 1985