Role of Lipid Metabolism and Signaling in Mammalian Oocyte Maturation, Quality, and Acquisition of Competence
Open Access
- 5 March 2021
- journal article
- review article
- Published by Frontiers Media SA in Frontiers in Cell and Developmental Biology
Abstract
It has been found that the quality of oocytes from obese women has been compromised and subsequent embryos displayed arrested development. The compromised quality may be either due to the poor or rich metabolic conditions such as imbalance or excession of lipids during oocyte development. Generally, lipids are mainly stored in the form of lipid droplets and are an important source of energy metabolism. Similarly, lipids are also essential signaling molecules involved in various biological cascades of oocyte maturation, growth and oocyte competence acquisition. To understand the role of lipids in controlling the oocyte development, we have comprehensively and concisely reviewed the literature and described the role of lipid metabolism in oocyte quality and maturation. Moreover, we have also presented a simplified model of fatty acid metabolism along with its implication on determining the oocyte quality and cryopreservation for fertilization.Keywords
Funding Information
- Ministry of Science and Technology of the People’s Republic of China (2018YFC1004700, 2016YFC1000600)
This publication has 161 references indexed in Scilit:
- Diversity, stability and resilience of the human gut microbiotaNature, 2012
- Nature, nurture or nutrition? Impact of maternal nutrition on maternal care, offspring development and reproductive functionJournal Of Physiology-London, 2012
- Vitamin E effect on controlled ovarian stimulation of unexplained infertile womenJournal of Assisted Reproduction and Genetics, 2012
- Associations between free fatty acids, cumulus oocyte complex morphology and ovarian function during in vitro fertilizationFertility and Sterility, 2011
- Follicle environment and quality of in vitro matured oocytesJournal of Assisted Reproduction and Genetics, 2011
- The potential functions of primary microRNAs in target recognition and repressionThe EMBO Journal, 2010
- Human luteinized granulosa cells secrete apoB100-containing lipoproteinsJournal of Lipid Research, 2010
- Activation of PKA, p38 MAPK and ERK1/2 by gonadotropins in cumulus cells is critical for induction of EGF-like factor and TACE/ADAM17 gene expression during in vitro maturation of porcine COCsJournal of Ovarian Research, 2009
- Genetic polymorphisms of FSHR, CYP17, CYP1A1, CAPN10, INSR, SERPINE1 genes in adolescent girls with polycystic ovary syndromeJournal of Assisted Reproduction and Genetics, 2009
- Metagenomic Analysis of the Human Distal Gut MicrobiomeScience, 2006