Randomized Controlled Trial of the Electrocardiographic Effects of Four Antimalarials for Pregnant Women with Uncomplicated Malaria on the Thailand-Myanmar Border
Open Access
- 18 March 2021
- journal article
- research article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 65 (4)
- https://doi.org/10.1128/aac.02473-20
Abstract
Quinoline antimalarials cause drug-induced electrocardiograph QT prolongation, a potential risk factor for torsade de pointes. The effects of currently used antimalarials on the electrocardiogram (ECG) were assessed in pregnant women with malaria.Funding Information
- Clarendon Fund
- Wellcome Trust (WT Major Overseas Programme in Southeast Asia)
- Holleypharm Pharmaceutical Company
This publication has 49 references indexed in Scilit:
- Concentration-dependent mortality of chloroquine in overdoseeLife, 2020
- Factors affecting the electrocardiographic QT interval in malaria: A systematic review and meta-analysis of individual patient dataPLoS Medicine, 2020
- The arrhythmogenic cardiotoxicity of the quinoline and structurally related antimalarial drugs: a systematic reviewBMC Medicine, 2018
- The influence of pregnancy on the pharmacokinetic properties of artemisinin combination therapy (ACT): a systematic reviewMalaria Journal, 2016
- Pharmacokinetics of drugs in pregnancySeminars in Perinatology, 2015
- Physiologic and pharmacokinetic changes in pregnancyFrontiers in Pharmacology, 2014
- Fatal cardiotoxicity related to halofantrine: a review based on a worldwide safety data baseMalaria Journal, 2009
- Cardiotoxicity of antimalarial drugsThe Lancet Infectious Diseases, 2007
- Cardiac effects of antimalarial treatment with halofantrineThe Lancet, 1993
- QUINIDINE IN FALCIPARUM MALARIAThe Lancet, 1981