Lifestyle Interventions Improving Cannabinoid Tone During COVID-19 Lockdowns May Enhance Compliance With Preventive Regulations and Decrease Psychophysical Health Complications
Open Access
- 16 July 2021
- journal article
- research article
- Published by Frontiers Media SA in Frontiers in Psychiatry
- Vol. 12, 565633
- https://doi.org/10.3389/fpsyt.2021.565633
Abstract
Studies investigating the psychosomatic effects of social isolation in animals have shown that one of the physiologic system that gets disrupted by this environment-affective change is the Endocannabinoid System. As the levels of endocannabinoids change in limbic areas and prefrontal cortex during stressful times, so is the subject more prone to fearful and negative thoughts and aggressive behavior. The interplay of social isolation on the hypothalamic-pituitary-adrenal axis and cannabinoid tone triggers a vicious cycle which further impairs the natural body's homeostatic neuroendocrine levels and provokes a series of risk factors for developing health complications. In this paper, we explore the psychosomatic impact of prolonged quarantine in healthy individuals, and propose management and coping strategies that may improve endocannabinoid tone, such as integration of probiotics, cannabidiol, meditation, and physical exercise interventions with the aim of supporting interpersonal, individual, and professional adherence with COVID-19 emergency public measures whilst minimizing their psycho-physical impact.This publication has 105 references indexed in Scilit:
- Contributions of endocannabinoid signaling to psychiatric disorders in humans: genetic and biochemical evidenceNeuroscience, 2012
- S-norfluoxetine microinfused into the basolateral amygdala increases allopregnanolone levels and reduces aggression in socially isolated miceNeuropharmacology, 2011
- Social isolation and chronic handling alter endocannabinoid signaling and behavioral reactivity to context in adult ratsNeuroscience, 2010
- Differential effects of chronic unpredictable stress on hippocampal CB1 receptors in male and female ratsBehavioural Brain Research, 2009
- Circulating endocannabinoids and N-acyl ethanolamines are differentially regulated in major depression and following exposure to social stressPsychoneuroendocrinology, 2009
- Repeated Homotypic Stress Elevates 2-Arachidonoylglycerol Levels and Enhances Short-Term Endocannabinoid Signaling at Inhibitory Synapses in Basolateral AmygdalaNeuropsychopharmacology, 2009
- Inhibition of fatty acid amide hydrolase by kaempferol and related naturally occurring flavonoidsBritish Journal of Pharmacology, 2008
- Beta-caryophyllene is a dietary cannabinoidProceedings of the National Academy of Sciences of the United States of America, 2008
- Decreased corticolimbic allopregnanolone expression during social isolation enhances contextual fear: A model relevant for posttraumatic stress disorderProceedings of the National Academy of Sciences of the United States of America, 2008
- Meta‐analysis of cannabinoid ligand binding affinity and receptor distribution: interspecies differencesBritish Journal of Pharmacology, 2007