Comparative Study of Lamina Cribrosa Thickness Between Primary Angle-Closure and Primary Open-Angle Glaucoma
Open Access
- 1 January 2021
- journal article
- research article
- Published by Taylor & Francis Ltd in Clinical Ophthalmology
- Vol. 15, 697-705
- https://doi.org/10.2147/OPTH.S296115
Abstract
Purpose: To compare lamina cribrosa thickness (LCT) of primary angle-closure glaucoma (PACG) and primary open-angle glaucoma (POAG) using the enhanced depth-imaging mode of the Heidelberg Spectralis spectral-domain optical coherence tomography (EDI-OCT). Patients and Methods: A comparative cross-sectional study was conducted. We enrolled 34 patients with PACG, 38 with POAG, and 62 controls, testing only one eye of each participant. Lamina cribrosa thickness was determined at the center of the optic nerve head using EDI-OCT. Nine points of LCT were measured, and LCT averages were analyzed. Results: Mean age, number of glaucoma medications, current intraocular pressure (IOP), cup to disc ratio, and visual field indices, were not significantly different between PACG and POAG eyes. The maximum IOP (SD) was higher in PACG than in POAG, at 32.5 (10.46) vs 25.05 (6.42) mmHg (p = 0.001), and LCTs were significantly different among the PACG, POAG and control groups. Mean (SD) LCTs were 226.99 (31.08), 257.17 (19.46), and 290.75 (28.02) mu m, respectively (p < 0.001). Lamina cribrosa thickness was correlated with mean deviation of the visual field (p = 0.001; correlation coefficient, rs = 0.347), while it was inversely correlated with maximum IOP (p < 0.001; correlation coefficient, rs = -0.592). Linear regression analysis revealed that LCT was inversely related to age (p = 0.008), female (p = 0.018), and maximum IOP (p = 0.002). LCT was marginally related to visual field MD (p = 0.053). Conclusion: Glaucomatous eyes had thinner LCT than controls, and maximum IOP was inversely correlated to the LCT. PACG eyes had higher maximum IOP and thinner LCT than POAG ones. In living eye, EDI-OCT emphasizes the pressure-dependent mechanism of glaucoma on lamina cribrosa deformation and the higher IOP-loaded stress which leads to a greater lamina cribrosa strain.This publication has 34 references indexed in Scilit:
- Spectral-Domain Optical Coherence Tomography Enhanced Depth Imaging of the Normal and Glaucomatous Nonhuman Primate Optic Nerve HeadInvestigative Ophthalmology & Visual Science, 2012
- The Impact of Acutely Elevated Intraocular Pressure on the Porcine Optic Nerve HeadInvestigative Ophthalmology & Visual Science, 2011
- Patterns of Damage in Chronic Angle-Closure Glaucoma Compared to Primary Open-Angle GlaucomaAmerican Journal of Ophthalmology, 2011
- Visualization of the Lamina Cribrosa Using Enhanced Depth Imaging Spectral-Domain Optical Coherence TomographyAmerican Journal of Ophthalmology, 2011
- Thickness of the lamina cribrosa and peripapillary sclera in Rhesus monkeys with nonglaucomatous or glaucomatous optic neuropathyActa Ophthalmologica, 2011
- Lamina Cribrosa and Peripapillary Sclera Histomorphometry in Normal and Advanced Glaucomatous Chinese Eyes with Various Axial LengthInvestigative Ophthalmology & Visual Science, 2009
- Age-related changes in the thickness of the human lamina cribrosaBritish Journal of Ophthalmology, 2006
- The number of people with glaucoma worldwide in 2010 and 2020British Journal of Ophthalmology, 2006
- Changes in retinal nerve fiber layer thickness after acute primary angle closureOphthalmology, 2004
- Vascular DysregulationJournal of Glaucoma, 1999