SD-OCT peripapillary nerve fibre layer and ganglion cell complex parameters in glaucoma: principal component analysis
- 3 June 2020
- journal article
- research article
- Published by BMJ in British Journal of Ophthalmology
- Vol. 105 (4), 496-501
- https://doi.org/10.1136/bjophthalmol-2020-316296
Abstract
Background/aims To identify objective glaucoma-related structural features based on peripapillary (p) and macular (m) spectral domain optical coherence tomography (SD-OCT) parameters and assess their discriminative ability between healthy and glaucoma patients. Methods Two hundred and sixty eyes (91 controls and 169 glaucoma) were included in this prospective study. After a complete examination, all participants underwent the posterior pole and the peripapillary retinal nerve fibre layer (pRNFL) protocols of the Spectralis SD-OCT. Principal component analysis (PCA), a data reduction method, was applied to identify and characterise the main information provided by the ganglion cell complex (GCC). The discriminative ability between healthy and glaucomatous eyes of the first principal components (PCs) was compared with that of conventional SD-OCT parameters (pRNFL, macular RNFL (mRNFL), macular ganglion cell layer (mGCL)and macular inner plexiform layer (mIPL)) using 10-fold cross-validated areas under the curve (AUC). Results The first PC explained 58% of the total information contained in the GCC and the pRNFL parameters and was the result of a general combination of almost all variables studied (diffuse distribution). Other PCs were driven mainly by pRNFL and mRNFL measurements. PCs and pRNFL had similar AUC (0.95 vs 0.96, p=0.88), and outperformed the other structural measurements: mRNFL (0.91, p=0.002), mGCL (0.92, p=0.02) and mIPL (0.92, p=0.0001). Conclusions PCA identified a diffuse representation of the papillary and macular SD-OCT parameters as the most important PC to summarise structural data in healthy and glaucomatous eyes. PCs and pRNFL parameters showed the greatest discriminative ability between healthy and glaucoma cases.Keywords
This publication has 31 references indexed in Scilit:
- Diagnosis of glaucoma and detection of glaucoma progression using spectral domain optical coherence tomographyCurrent Opinion in Opthalmology, 2013
- Shape Analysis of the Peripapillary RPE Layer in Papilledema and Ischemic Optic NeuropathyInvestigative Ophthalmology & Visual Science, 2011
- Influence of Disc Size on Optic Nerve Head versus Retinal Nerve Fiber Layer Assessment for Diagnosing GlaucomaOphthalmology, 2011
- Human Chorioretinal Layer Thicknesses Measured in Macula-wide, High-Resolution Histologic SectionsInvestigative Ophthalmology & Visual Science, 2011
- Ability of Cirrus HD-OCT Optic Nerve Head Parameters to Discriminate Normal from Glaucomatous EyesOphthalmology, 2011
- Imaging of the retinal nerve fibre layer with spectral domain optical coherence tomography for glaucoma diagnosisBritish Journal of Ophthalmology, 2010
- Diagnostic Tools for Glaucoma Detection and ManagementSurvey of Ophthalmology, 2008
- Using unsupervised learning with independent component analysis to identify patterns of glaucomatous visual field defects.Investigative Ophthalmology & Visual Science, 2005
- Sources of bias in studies of optic disc and retinal nerve fibre layer morphologyBritish Journal of Ophthalmology, 1998
- An index of factorial simplicityPsychometrika, 1974