Recently, there have been hundreds of lip color cosmetics on the market in various colors. However, not all lip colors are safe to use. Without realizing it, there are lip dyes that contain dyes that are dangerous and are prohibited because they can cause irritation to the skin and respiratory tract. Therefore, it is better to use natural dyes. One of the sources of natural dyes is the fruit of kesumba. Extracts from simplicia of kesumba seeds were made by percolation using 96% ethanol as a solvent. The lipstick formulation formula consists of Cera alba, vaseline alba, lanolin, carnauba wax, cetyl alcohol, oleum ricini, propylene glycol, titanium dioxide, butylhydroxytoluene, tween 80, rose oil (oleum rosae), and nipagin, as well as the addition of kesumba seed extract with concentrations of 15%, 17.5%, 20%, 22.5%, and 25%. Tests on the preparations made included examination of the melting point, homogeneity, lipstick strength, stability test against changes in shape, color, and odor during 30 days of storage at room temperature, smear test, and pH examination, and irritation test preference test (Hedonic test). The results of the research that the extract of the kesumba fruit seed can be formulated in lipstick preparations with a light yellow to dark maroon color. The formulation of the kesumba seed extract in the lipstick preparation shows that the preparation is relatively stable homogeneous, the melting point is 58°C, has a good lipstick strength, the pH ranges from 6.3 to 5.7 (according to the pH of the skin) easy to apply with an even color. , does not irritate, so it is safe to use; the pretty preferred preparations are preparations 2, 3, and 4, namely the formula with extracts of kesumba seeds with concentrations of 17.5%, 20%, and 22.5%.