High-efficiency and safe sulfur-doped iron oxides for magnetic resonance imaging-guided photothermal/magnetic hyperthermia therapy
- 23 March 2020
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Dalton Transactions
- Vol. 49 (17), 5493-5502
- https://doi.org/10.1039/d0dt00297f
Abstract
Heat therapy is a promising therapeutic modality for cancer treatment due to the minimum adverse effects of selective local hyperthermia; however, the low heating efficiency of heat therapy under safe conditions is an issue for its bioapplication. Here, we report the synthesis of water-dispersible sulfur doped iron oxides (SDIOs) with different phase structures and the exploration of the relationships between the different SDIOs and their induction heating capacities as a guideline to obtain a photo-magnetic hyperthermia agent. The agent exhibits good biocompatibility, excellent photothermal conversion efficiency (55.8%) and great T2 weighted magnetic resonance imaging (63.7 mM−1 s−1). Significantly, the SDIOs effectively eliminate tumours in a biologically safe AC magnetic field range (H·f = 4.3 < 5.0 × 106 kA m−1 s−1) and with 808 nm laser irradiation at a safe density of 0.33 W cm−2; also, they can be mostly metabolized from the body after one month. The work presented here adopts anion-doped iron oxides to dramatically improve photo-magnetic hyperthermia effects and may enable further exploration in thermotherapeutic research.Keywords
Funding Information
- National Natural Science Foundation of China (11974074, 51972055, 51672044, 51702348)
- Science and Technology Commission of Shanghai Municipality (18ZR1402000)
- Science and Technology Planning Project of Shenzhen Municipality (JCYJ20180508152903208)
- Fundamental Research Funds for the Central Universities
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