Normobaric Oxygen May Ameliorate Cerebral Venous Outflow Disturbance-Related Neurological Symptoms
Open Access
- 13 November 2020
- journal article
- research article
- Published by Frontiers Media SA in Frontiers in Neurology
Abstract
Cerebral venous outflow disturbance (CVOD) has begun to garner the attention of researches owing to a series of clinical symptoms that impose a significant impact on people's quality of life. Herein, we aimed to investigate whether normobaric oxygen (NBO) can ameliorate CVOD-induced neurological symptoms. This was one part of the prospective trial registered in (NCT03373292). A total of 37 CVOD patients were divided into the NBO group (5-8 L/min of oxygen inhalation, 1 h per time, 3 times daily, n = 19) and the control group (without oxygen inhalation, n = 18) randomly. The assessments were performed at admission, 1-week hospitalization, and 6-month follow-up. Quantitative electroencephalogram (qEEG) data were recorded prior to and post 1 h of NBO in some patients. R software was used for data analysis. No NBO-related adverse events were observed during the whole NBO intervention process. The 1-week Patient Global Impression of Change (PGIC) scale showed that the symptom improvement occurred in nine patients in the NBO group (47.4%) while none in the control group (p = 0.001). NBO could improve headache evaluated with visual analog scale (pre-NBO vs. post-NBO: 4.70 +/- 2.16 vs. 2.90 +/- 2.03, p = 0.024) and Headache Impact Test-6 (53.40 +/- 12.15 vs. 50.30 +/- 13.04, p = 0.041). As for 6-month PGIC follow-up, eight out of 14 cases (57.1%) in the NBO group reported improvement, while only one out of 12 patients in the control group replied mild improvement (p = 0.014). The qEEG revealed that NBO reduced the ratio of theta to alpha power (0.65 +/- 0.38 vs. 0.56 +/- 0.35, p = 0.030) over the fronto-central electrodes. To sum up, NBO may be a safe and effective approach to attenuate CVOD-related symptoms (especially for headache) by brain functional improvement resulting from increasing oxygen supply to the brain tissues.Funding Information
- National Natural Science Foundation of China
This publication has 42 references indexed in Scilit:
- Potential involvement of the extracranial venous system in central nervous system disorders and agingBMC Medicine, 2013
- The role of noninvasive and invasive diagnostic imaging techniques for detection of extra-cranial venous system anomalies and developmental variantsBMC Medicine, 2013
- EEG in ischaemic stroke: Quantitative EEG can uniquely inform (sub-)acute prognoses and clinical managementClinical Neurophysiology, 2013
- Transverse Sinus Stenting for Idiopathic Intracranial Hypertension: A Review of 52 Patients and of Model PredictionsAmerican Journal of Neuroradiology, 2011
- Advancement in idiopathic intracranial hypertension pathogenesis: focus on sinus venous stenosisNeurological Sciences, 2010
- Progressive Staging of Pilot Studies to Improve Phase III Trials for Motor InterventionsNeurorehabilitation and Neural Repair, 2008
- Considerations in determining sample size for pilot studiesResearch in Nursing & Health, 2008
- Hyperbaric Oxygen Therapy in Acute Ischemic StrokeStroke, 2003
- Validation of the Insomnia Severity Index as an outcome measure for insomnia researchSleep Medicine, 2001
- The Hospital Anxiety and Depression ScaleActa Psychiatrica Scandinavica, 1983