Cytology meets next generation sequencing and liquid biopsy: A case of lung adenocarcinoma presenting as metastasis to the phalanx
- 22 April 2020
- journal article
- research article
- Published by Wiley in Diagnostic Cytopathology
- Vol. 48 (8), 759-764
- https://doi.org/10.1002/dc.24438
Abstract
Carcinomas do rarely metastasize to the finger. Non‐small‐cell lung cancer is most frequently involved. To date, only a few cases have been reported, on histology. Here we describe the cytological features of a metastatic lung adenocarcinoma case to the phalanx of the right forefinger as initial manifestation of the neoplastic disease in a 69‐years‐old woman. The cytological microscopic findings, complemented by a wide array of ancillary techniques, were confirmed by histology. Neoplastic cells were positive for cytokeratin 7 (CK7) and thyroid transcription factor 1 (TTF‐1), harboring, in tissue and in bloodstream samples, an uncommon epidermal growth factor receptor (EGFR) exon 20 p.S768_D760DUP, detected by next generation sequencing (NGS) and liquid biopsy. Cytology corroborated by immunocytochemistry, NGS, and liquid biopsy is a modern approach to provide diagnostic and therapeutic information even in rare and challenging cases.Keywords
This publication has 21 references indexed in Scilit:
- Development of a gene panel for next-generation sequencing of clinically relevant mutations in cell-free DNA from cancer patientsBritish Journal of Cancer, 2017
- Cytopathologists can reliably perform ultrasound-guided thyroid fine needle aspiration: a 1-year audit on 3715 consecutive casesCytopathology, 2016
- Oblique wave interaction with porous, flexible barriers in a two-layer fluidJournal of Engineering Mathematics, 2015
- Lung Metastasis Mimicking Fingertip InfectionCase Reports in Oncological Medicine, 2015
- Radiotherapy for a Phalanx Bone Metastasis of a Lung AdenocarcinomaCase Reports in Oncology, 2014
- EGFR Mutations Detected on Cytology Samples by a Centralized Laboratory Reliably Predict Response to Gefitinib in Non-Small Cell Lung Carcinoma PatientsCancer Cytopathology, 2013
- “The petals and thorns” of ROSE (rapid on‐site evaluation)Cancer Cytopathology, 2012
- Digital acrometastasis: a rare initial sign of occult pulmonary squamous cell carcinomaJournal of Plastic, Reconstructive & Aesthetic Surgery, 2009
- Two Cases of Acrometastasis to the Hands and Review of the LiteratureCurrent Oncology, 2008
- The hand in metastatic diseaseThe Journal of Hand Surgery, 1987