Circulating Extracellular Vesicles: The Missing Link between Physical Exercise and Depression Management?
Open Access
- 6 January 2021
- journal article
- review article
- Published by MDPI AG in International Journal of Molecular Sciences
- Vol. 22 (2), 542
- https://doi.org/10.3390/ijms22020542
Abstract
Depression is associated with an increased risk of aging-related diseases. It is also seemingly a common psychological reaction to pandemic outbreaks with forced quarantines and lockdowns. Thus, depression represents, now more than ever, a major global health burden with therapeutic management challenges. Clinical data highlights that physical exercise is gaining momentum as a non-pharmacological intervention in depressive disorders. Although it may contribute to the reduction of systemic inflammation associated with depression, the mechanisms underlying the beneficial physical exercise effects in emotional behavior remain to be elucidated. Current investigations indicate that a rapid release of extracellular vesicles into the circulation might be the signaling mediators of systemic adaptations to physical exercise. These biological entities are now well-established intercellular communicators, playing a major role in relevant physiological and pathophysiological functions, including brain cell–cell communication. We also reviewed emerging evidence correlating depression with modified circulating extracellular vesicle surfaces and cargo signatures (e.g., microRNAs and proteins), envisioned as potential biomarkers for diagnosis, efficient disease stratification and appropriate therapeutic management. Accordingly, the clinical data summarized in the present review prompted us to hypothesize that physical exercise-related circulating extracellular vesicles contribute to its antidepressant effects, particularly through the modulation of inflammation. This review sheds light on the triad “physical exercise–extracellular vesicles–depression” and suggests new avenues in this novel emerging field.Funding Information
- Fundação para a Ciência e a Tecnologia (POCI-01-0145-FEDER-030786, UID/NEU/04539/2019)
- Programa Operacional Regional do Centro (CENTRO-01-0145-FEDER-000012: HealthyAging2020, CENTRO-01-0145-FEDER- 000008: BrainHealth 2020)
- Programa Operacional Temático Factores de Competitividade (POCI-01-0145-FEDER-007440)
This publication has 121 references indexed in Scilit:
- Circulating MicroRNAs and Aerobic Fitness – The HUNT-StudyPLOS ONE, 2013
- EVpedia: an integrated database of high‐throughput data for systemic analyses of extracellular vesiclesJournal of Extracellular Vesicles, 2013
- Physical exercise and Parkinson’s disease: influence on symptoms, disease course and preventionProgress in Neurobiology, 2013
- Dynamic regulation of circulating microRNA during acute exhaustive exercise and sustained aerobic exercise trainingJournal Of Physiology-London, 2011
- Dysbiosis of fecal microbiota in Crohnʼs disease patients as revealed by a custom phylogenetic microarrayInflammatory Bowel Diseases, 2010
- Endothelial-derived microparticles: Biological conveyors at the crossroad of inflammation, thrombosis and angiogenesisThrombosis and Haemostasis, 2010
- BDNF genotype moderates the relation between physical activity and depressive symptoms.Health Psychology, 2010
- Born to Be Criminal? What to Make of Early Biological Risk Factors for Criminal BehaviorAmerican Journal of Psychiatry, 2010
- The anti-inflammatory effect of exerciseJournal of Applied Physiology, 2005
- The BDNF val66met Polymorphism Affects Activity-Dependent Secretion of BDNF and Human Memory and Hippocampal FunctionCell, 2003