The Role of Autophagy in Inflammatory Bowel Disease
Open Access
- 3 February 2021
- journal article
- review article
- Published by Frontiers Media SA in Frontiers in Physiology
Abstract
Inflammatory bowel disease (IBD) is an idiopathic intestinal inflammatory disease, including ulcerative colitis (UC) and Crohn’s disease (CD). The abnormality of inflammatory and immune responses in the intestine contributes to the pathogenesis and progression of IBD. Autophagy is a vital catabolic process in cells. Recent studies report that autophagy is highly involved in various kinds of diseases, especially inflammation-related diseases, such as IBD. In this review, the biological characteristics of autophagy and its role in IBD will be described and discussed based on recent literature. In addition, several therapies for IBD through modulating the inflammasome and intestinal microbiota taking advantage of autophagy regulation will be introduced. We aim to bring new insight in the exploration of mechanisms for IBD and development of novel therapeutic strategies against IBD.Keywords
This publication has 150 references indexed in Scilit:
- Intestinal Inflammation and Mucosal Barrier FunctionInflammatory Bowel Diseases, 2014
- Intestinal permeability – a new target for disease prevention and therapyBMC Gastroenterology, 2014
- Lipidation of the LC3/GABARAP family of autophagy proteins relies on a membrane-curvature-sensing domain in Atg3Nature, 2014
- MIR106B and MIR93 Prevent Removal of Bacteria From Epithelial Cells by Disrupting ATG16L1-Mediated AutophagyGastroenterology, 2014
- The NLRP3 Inflammasome: A Sensor for Metabolic Danger?Science, 2010
- Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseasesProceedings of the National Academy of Sciences of the United States of America, 2007
- Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesisNature Genetics, 2007
- A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1Nature Genetics, 2006
- Differential activation of the inflammasome by caspase-1 adaptors ASC and IpafNature, 2004
- Ulcerative colitis and Crohn's disease in an unselected population of monozygotic and dizygotic twins. A study of heritability and the influence of smoking.Gut, 1988