Structural brain abnormalities in children and adolescents with comorbid autism spectrum disorder and attention-deficit/hyperactivity disorder
Open Access
- 9 December 2019
- journal article
- research article
- Published by Springer Science and Business Media LLC in Translational Psychiatry
- Vol. 9 (1), 1-7
- https://doi.org/10.1038/s41398-019-0679-z
Abstract
Autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD) share high rates of comorbidity, with the Diagnostic and Statistical Manual of Mental Disorders-Fifth Edition now acknowledging the comorbid diagnosis of ASD and ADHD. Although structural abnormalities in the prefrontal cortex, cerebellum, and basal ganglia occur in both ASD and ADHD, no structural studies have focused exclusively on patients with comorbid ASD and ADHD. We thus aimed to clarify the structural features and developmental changes in patients with comorbid ASD and ADHD in a relatively large sample from two sites. Ninety-two patients were age-matched to 141 typically developing (TD) controls (age range: 5–16 years) and assessed for volumetric characteristics using structural magnetic resonance imaging (i.e. surface-based morphometry). While there were no significant differences in prefrontal cortex, cerebellum, and basal ganglia volumes, patients with ASD and ADHD exhibited significantly lower left postcentral gyrus volumes than TD controls. We observed significantly lower postcentral gyrus volumes exclusively in children and preadolescents, and not in adolescents. Our findings suggest that abnormal somatosensory, attributed to delayed maturation of the left postcentral gyrus, leads to the core symptoms experienced by patients with comorbid ASD and ADHD.Keywords
Funding Information
- Ministry of Education, Culture, Sports, Science and Technology (#17K19898, #19H00617, 16K16621, 18K131106)
- Takeda Science Foundation
- Scientific Research from the Japan-United States Brain Research Cooperation Program
This publication has 50 references indexed in Scilit:
- Disorder-Specific Predictive Classification of Adolescents with Attention Deficit Hyperactivity Disorder (ADHD) Relative to Autism Using Structural Magnetic Resonance ImagingPLOS ONE, 2013
- FreeSurferNeuroImage, 2012
- A Meta-Analysis of the Corpus Callosum in AutismBiological Psychiatry, 2009
- Total Brain Volume and Corpus Callosum Size in Medication-Naïve Adolescents and Young Adults with Autism Spectrum DisorderBiological Psychiatry, 2009
- Mapping brain abnormalities in boys with autismHuman Brain Mapping, 2009
- Psychostimulant Treatment and the Developing Cortex in Attention Deficit Hyperactivity DisorderAmerican Journal of Psychiatry, 2009
- Psychiatric Disorders in Children With Autism Spectrum Disorders: Prevalence, Comorbidity, and Associated Factors in a Population-Derived SampleJournal of the American Academy of Child & Adolescent Psychiatry, 2008
- Structural brain change in Attention Deficit Hyperactivity Disorder identified by meta-analysisBMC Psychiatry, 2008
- Attention-deficit/hyperactivity disorder is characterized by a delay in cortical maturationProceedings of the National Academy of Sciences of the United States of America, 2007
- Synchrony of Chromosome DuplicationNature, 1966